ZA200610639B - Methods for improving bioavailability for a renin inhibitor - Google Patents
Methods for improving bioavailability for a renin inhibitor Download PDFInfo
- Publication number
- ZA200610639B ZA200610639B ZA200610639A ZA200610639A ZA200610639B ZA 200610639 B ZA200610639 B ZA 200610639B ZA 200610639 A ZA200610639 A ZA 200610639A ZA 200610639 A ZA200610639 A ZA 200610639A ZA 200610639 B ZA200610639 B ZA 200610639B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- hydroxy
- inhibitor
- aryl
- acid amide
- Prior art date
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- 230000036963 noncompetitive effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 235000015424 sodium Nutrition 0.000 description 1
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- WQDUMFSSJAZKTM-UHFFFAOYSA-N sodium methoxide Substances [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
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- 238000012353 t test Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59870004P | 2004-08-03 | 2004-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200610639B true ZA200610639B (en) | 2008-05-28 |
Family
ID=35056890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200610639A ZA200610639B (en) | 2004-08-03 | 2006-12-18 | Methods for improving bioavailability for a renin inhibitor |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7709532B2 (fr) |
| EP (2) | EP2191823A1 (fr) |
| JP (1) | JP5134366B2 (fr) |
| KR (1) | KR20070040384A (fr) |
| CN (1) | CN1993116B (fr) |
| AR (1) | AR050043A1 (fr) |
| AT (1) | ATE449601T1 (fr) |
| AU (1) | AU2005268844B2 (fr) |
| BR (1) | BRPI0514021A (fr) |
| CA (1) | CA2572743C (fr) |
| CY (1) | CY1109826T1 (fr) |
| DE (1) | DE602005017905D1 (fr) |
| DK (1) | DK1776099T3 (fr) |
| EC (1) | ECSP077169A (fr) |
| ES (1) | ES2335597T3 (fr) |
| HR (1) | HRP20100064T1 (fr) |
| IL (1) | IL180678A (fr) |
| MA (1) | MA28821B1 (fr) |
| MX (1) | MX2007001339A (fr) |
| MY (1) | MY142180A (fr) |
| NO (1) | NO20071142L (fr) |
| NZ (1) | NZ552903A (fr) |
| PE (1) | PE20060416A1 (fr) |
| PL (1) | PL1776099T3 (fr) |
| PT (1) | PT1776099E (fr) |
| RU (1) | RU2404758C2 (fr) |
| SI (1) | SI1776099T1 (fr) |
| TN (1) | TNSN07038A1 (fr) |
| TW (1) | TW200616610A (fr) |
| WO (1) | WO2006013094A1 (fr) |
| ZA (1) | ZA200610639B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891937A1 (fr) * | 2006-08-25 | 2008-02-27 | Novartis AG | Formulations galéniques de l'aliskiren |
| EP1927350A1 (fr) * | 2006-11-24 | 2008-06-04 | Novartis AG | Procéde pour améliorer la biodisponibilite d'un inhibiteur de renine |
| WO2011012319A1 (fr) | 2009-07-31 | 2011-02-03 | Sandoz Ag | Procede de preparation de ö-amino-alcaneamides et ω-amino-alcanethioamides |
| WO2012010651A2 (fr) | 2010-07-23 | 2012-01-26 | Sandoz Ag | Procédé de préparation d'oméga-amino-alcaneamides et d'oméga-amino-alcanethioamides et intermédiaires de ce procédé |
| WO2014168255A1 (fr) * | 2013-04-12 | 2014-10-16 | 国立大学法人京都大学 | Accélérateur de la maturation de mégacaryocytes |
| WO2015035218A1 (fr) * | 2013-09-05 | 2015-03-12 | Howard University | Procédé renforçant la biodisponibilité d'un médicament anti-vih |
| JP6029621B2 (ja) * | 2014-07-14 | 2016-11-24 | ヤマサ醤油株式会社 | 血漿レニン活性の測定法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL108499A (en) | 1993-02-04 | 2000-02-29 | Lilly Co Eli | Mammalian influx peptide transporter |
| US5567592A (en) | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| US5716928A (en) * | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| EP0831870A4 (fr) | 1995-06-07 | 1998-09-16 | Avmax Inc | Utilisation d'huiles essentielles pour accroitre la biodisponibilite des composes pharmaceutiques oraux |
| CO5251425A1 (es) * | 1999-10-27 | 2003-02-28 | Baker Norton Pharma | Metodo y composiciones para administrar taxanos oralmente a pacientes humanos |
| JP2003522152A (ja) * | 2000-02-11 | 2003-07-22 | プラエシス ファーマシューティカルズ インコーポレーテッド | 薬物の生物学的利用能を高める方法 |
| WO2001092468A2 (fr) * | 2000-05-31 | 2001-12-06 | Rutgers, The State University Of New Jersey | Nouvelles compositions pour l'expression du transporteur 1 d'histidine de peptide humain et leurs procedes d'utilisation |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| GB0113663D0 (en) * | 2001-06-05 | 2001-07-25 | Novartis Ag | Use of organic compounds |
| EP1465592A2 (fr) | 2001-12-19 | 2004-10-13 | Alza Corporation | Preparation et forme posologique pour l'augmentation de la biodisponibilite buccale de macromolecules hydrophiles |
| US6869970B2 (en) * | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
| EP1501546B1 (fr) * | 2002-05-03 | 2012-10-10 | Hexal AG | Formulation pharmaceutique stable contenant une statine combinee avec un inhibiteur de l'ace |
| US20050147629A1 (en) * | 2002-06-28 | 2005-07-07 | Jutta Riedl | Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant |
| TW200605867A (en) * | 2004-03-17 | 2006-02-16 | Novartis Ag | Use of organic compounds |
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2005
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- 2005-08-01 AR ARP050103198A patent/AR050043A1/es not_active Application Discontinuation
- 2005-08-02 SI SI200530915T patent/SI1776099T1/sl unknown
- 2005-08-02 DK DK05769973.8T patent/DK1776099T3/da active
- 2005-08-02 AU AU2005268844A patent/AU2005268844B2/en not_active Ceased
- 2005-08-02 CN CN2005800261744A patent/CN1993116B/zh not_active Expired - Fee Related
- 2005-08-02 ES ES05769973T patent/ES2335597T3/es active Active
- 2005-08-02 EP EP09014648A patent/EP2191823A1/fr not_active Withdrawn
- 2005-08-02 RU RU2007107850/15A patent/RU2404758C2/ru not_active IP Right Cessation
- 2005-08-02 MY MYPI20053584A patent/MY142180A/en unknown
- 2005-08-02 BR BRPI0514021-8A patent/BRPI0514021A/pt not_active IP Right Cessation
- 2005-08-02 KR KR1020077002718A patent/KR20070040384A/ko active IP Right Grant
- 2005-08-02 JP JP2007524264A patent/JP5134366B2/ja not_active Expired - Fee Related
- 2005-08-02 AT AT05769973T patent/ATE449601T1/de active
- 2005-08-02 PT PT05769973T patent/PT1776099E/pt unknown
- 2005-08-02 US US11/572,471 patent/US7709532B2/en not_active Expired - Fee Related
- 2005-08-02 EP EP05769973A patent/EP1776099B1/fr active Active
- 2005-08-02 MX MX2007001339A patent/MX2007001339A/es active IP Right Grant
- 2005-08-02 DE DE602005017905T patent/DE602005017905D1/de active Active
- 2005-08-02 TW TW094126194A patent/TW200616610A/zh unknown
- 2005-08-02 PL PL05769973T patent/PL1776099T3/pl unknown
- 2005-08-02 NZ NZ552903A patent/NZ552903A/en not_active IP Right Cessation
- 2005-08-02 CA CA2572743A patent/CA2572743C/fr not_active Expired - Fee Related
- 2005-08-02 WO PCT/EP2005/008369 patent/WO2006013094A1/fr active Application Filing
-
2006
- 2006-12-18 ZA ZA200610639A patent/ZA200610639B/en unknown
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2007
- 2007-01-11 IL IL180678A patent/IL180678A/en not_active IP Right Cessation
- 2007-01-15 EC EC2007007169A patent/ECSP077169A/es unknown
- 2007-02-02 TN TNP2007000038A patent/TNSN07038A1/en unknown
- 2007-02-22 MA MA29709A patent/MA28821B1/fr unknown
- 2007-02-28 NO NO20071142A patent/NO20071142L/no not_active Application Discontinuation
-
2010
- 2010-01-05 CY CY20101100019T patent/CY1109826T1/el unknown
- 2010-02-02 HR HR20100064T patent/HRP20100064T1/hr unknown
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