ZA200610127B - Butyrylcholinesterase selective inhibitors - Google Patents
Butyrylcholinesterase selective inhibitors Download PDFInfo
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- ZA200610127B ZA200610127B ZA200610127A ZA200610127A ZA200610127B ZA 200610127 B ZA200610127 B ZA 200610127B ZA 200610127 A ZA200610127 A ZA 200610127A ZA 200610127 A ZA200610127 A ZA 200610127A ZA 200610127 B ZA200610127 B ZA 200610127B
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- ZA
- South Africa
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- substituted
- unsubstituted
- pharmaceutically acceptable
- prodrug
- solvate
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
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- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical class NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
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- 239000002243 precursor Substances 0.000 description 1
- 238000004237 preparative chromatography Methods 0.000 description 1
- CDOZDBSBBXSXLB-UHFFFAOYSA-N profenamine Chemical compound C1=CC=C2N(CC(C)N(CC)CC)C3=CC=CC=C3SC2=C1 CDOZDBSBBXSXLB-UHFFFAOYSA-N 0.000 description 1
- 229960002262 profenamine Drugs 0.000 description 1
- VXPCQISYVPFYRK-UHFFFAOYSA-N profenamine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(CC)CC)C3=CC=CC=C3SC2=C1 VXPCQISYVPFYRK-UHFFFAOYSA-N 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04076585A EP1600447A1 (en) | 2004-05-28 | 2004-05-28 | Butyrylcholinesterase selective inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200610127B true ZA200610127B (en) | 2008-07-30 |
Family
ID=34928246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200610127A ZA200610127B (en) | 2004-05-28 | 2005-05-27 | Butyrylcholinesterase selective inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080119521A1 (ru) |
| EP (2) | EP1600447A1 (ru) |
| JP (1) | JP2008500985A (ru) |
| CN (1) | CN1960986A (ru) |
| AT (1) | ATE457984T1 (ru) |
| AU (1) | AU2005250124B2 (ru) |
| BR (1) | BRPI0510865A (ru) |
| CA (1) | CA2566594A1 (ru) |
| DE (1) | DE602005019406D1 (ru) |
| DK (1) | DK1758888T3 (ru) |
| ES (1) | ES2340298T3 (ru) |
| IL (1) | IL179105A0 (ru) |
| MX (1) | MXPA06013783A (ru) |
| PL (1) | PL1758888T3 (ru) |
| PT (1) | PT1758888E (ru) |
| RU (1) | RU2386627C2 (ru) |
| WO (1) | WO2005118570A1 (ru) |
| ZA (1) | ZA200610127B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060135252A1 (en) * | 2004-12-22 | 2006-06-22 | Amaitis Lee M | System and method for betting on a subset of participants in an event according to multiple groups |
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| TW201031665A (en) | 2009-02-04 | 2010-09-01 | Gruenenthal Gmbh | Substituted indole-compound |
| CN113387867B (zh) * | 2021-07-15 | 2023-03-14 | 南华大学 | 一种氨基甲酸酯类邻氨基苯甲酸色胺衍生物及其制备与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| FR2644786B1 (fr) * | 1989-03-21 | 1993-12-31 | Adir Cie | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US5428043A (en) * | 1990-02-08 | 1995-06-27 | Pfizer Inc. | Tricyclic-cyclic amines as novel cholinesterase inhibitors |
| US5965574A (en) * | 1996-08-13 | 1999-10-12 | Chen; Yuhpyng Liang | Heteroaryl amines as novel acetylcholinesterase inhibitors |
| TW263504B (ru) * | 1991-10-03 | 1995-11-21 | Pfizer | |
| UA67757C2 (ru) * | 1997-11-18 | 2004-07-15 | Тейджин Лімітед | Производные циклических аминов и их применение в качестве лекарственных средств |
| WO2001098271A1 (fr) * | 2000-06-21 | 2001-12-27 | Eisai Co., Ltd. | Compose piperidine 4-substitue |
| US7838518B2 (en) * | 2002-02-12 | 2010-11-23 | N.V. Organon | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
-
2004
- 2004-05-28 EP EP04076585A patent/EP1600447A1/en not_active Withdrawn
-
2005
- 2005-05-27 CN CNA2005800172810A patent/CN1960986A/zh active Pending
- 2005-05-27 PT PT05748329T patent/PT1758888E/pt unknown
- 2005-05-27 PL PL05748329T patent/PL1758888T3/pl unknown
- 2005-05-27 DE DE602005019406T patent/DE602005019406D1/de active Active
- 2005-05-27 MX MXPA06013783A patent/MXPA06013783A/es active IP Right Grant
- 2005-05-27 BR BRPI0510865-9A patent/BRPI0510865A/pt not_active IP Right Cessation
- 2005-05-27 WO PCT/EP2005/005816 patent/WO2005118570A1/en active Application Filing
- 2005-05-27 AU AU2005250124A patent/AU2005250124B2/en not_active Ceased
- 2005-05-27 ES ES05748329T patent/ES2340298T3/es active Active
- 2005-05-27 JP JP2007513831A patent/JP2008500985A/ja active Pending
- 2005-05-27 AT AT05748329T patent/ATE457984T1/de active
- 2005-05-27 DK DK05748329.9T patent/DK1758888T3/da active
- 2005-05-27 CA CA002566594A patent/CA2566594A1/en not_active Abandoned
- 2005-05-27 EP EP05748329A patent/EP1758888B8/en active Active
- 2005-05-27 US US11/569,387 patent/US20080119521A1/en not_active Abandoned
- 2005-05-27 ZA ZA200610127A patent/ZA200610127B/en unknown
- 2005-05-27 RU RU2006146946/04A patent/RU2386627C2/ru not_active IP Right Cessation
-
2006
- 2006-11-07 IL IL179105A patent/IL179105A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2566594A1 (en) | 2005-12-15 |
| WO2005118570A1 (en) | 2005-12-15 |
| DE602005019406D1 (de) | 2010-04-01 |
| DK1758888T3 (da) | 2010-06-07 |
| BRPI0510865A (pt) | 2007-12-26 |
| ES2340298T3 (es) | 2010-06-01 |
| MXPA06013783A (es) | 2007-08-14 |
| EP1758888B1 (en) | 2010-02-17 |
| EP1600447A1 (en) | 2005-11-30 |
| AU2005250124B2 (en) | 2011-01-06 |
| EP1758888B8 (en) | 2010-04-07 |
| RU2386627C2 (ru) | 2010-04-20 |
| ATE457984T1 (de) | 2010-03-15 |
| RU2006146946A (ru) | 2008-07-10 |
| IL179105A0 (en) | 2007-03-08 |
| EP1758888A1 (en) | 2007-03-07 |
| PT1758888E (pt) | 2010-04-29 |
| CN1960986A (zh) | 2007-05-09 |
| AU2005250124A1 (en) | 2005-12-15 |
| US20080119521A1 (en) | 2008-05-22 |
| PL1758888T3 (pl) | 2010-07-30 |
| JP2008500985A (ja) | 2008-01-17 |
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