ZA200607518B - Pyrimidine derivatives for use as vanilloid receptor ligands and their use in the treatment of pain - Google Patents

Pyrimidine derivatives for use as vanilloid receptor ligands and their use in the treatment of pain Download PDF

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Publication number
ZA200607518B
ZA200607518B ZA200607518A ZA200607518A ZA200607518B ZA 200607518 B ZA200607518 B ZA 200607518B ZA 200607518 A ZA200607518 A ZA 200607518A ZA 200607518 A ZA200607518 A ZA 200607518A ZA 200607518 B ZA200607518 B ZA 200607518B
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South Africa
Prior art keywords
ethyl
piperazinyl
pyrimidinyl
oxy
fluorophenyl
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ZA200607518A
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English (en)
Inventor
Balan Chenera
Elizabeth M Doherty
James R Falsey
Gore Vijay Keshav
Katon Jodie
Mark H Norman
Wang Hui-Ling
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Amgen Inc
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Publication of ZA200607518B publication Critical patent/ZA200607518B/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200607518A 2004-02-11 2006-09-08 Pyrimidine derivatives for use as vanilloid receptor ligands and their use in the treatment of pain ZA200607518B (en)

Applications Claiming Priority (1)

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US54389604P 2004-02-11 2004-02-11

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ZA200607518B true ZA200607518B (en) 2008-07-30

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ZA200607518A ZA200607518B (en) 2004-02-11 2006-09-08 Pyrimidine derivatives for use as vanilloid receptor ligands and their use in the treatment of pain

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US (1) US7511044B2 (zh)
EP (1) EP1720868B1 (zh)
JP (1) JP2007522235A (zh)
KR (1) KR100813093B1 (zh)
CN (1) CN1953976A (zh)
AR (1) AR049771A1 (zh)
AT (1) ATE447570T1 (zh)
AU (1) AU2005212517B2 (zh)
BR (1) BRPI0507927A (zh)
CA (1) CA2555685A1 (zh)
DE (1) DE602005017468D1 (zh)
EA (1) EA010265B1 (zh)
ES (1) ES2333973T3 (zh)
IL (1) IL177369A0 (zh)
MY (1) MY139645A (zh)
NO (1) NO20064055L (zh)
TW (1) TWI295670B (zh)
WO (1) WO2005077944A1 (zh)
ZA (1) ZA200607518B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006740A1 (ja) * 2004-07-14 2006-01-19 Japan Tobacco Inc. ３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤
NZ552086A (en) 2004-07-15 2009-12-24 Japan Tobacco Inc Fused benzamide compound and vanilloid receptor 1 (VR1) activity inhibitor
WO2006089311A1 (en) * 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1967519B1 (en) * 2005-12-28 2012-09-05 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compound and inhibitor of vanilloid receptor type 1 (vr1) activity
US7906508B2 (en) * 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
EP2211862A2 (en) * 2007-10-18 2010-08-04 Novartis AG Csf-1r inhibitors for treatment of cancer and bone diseases
US8012254B2 (en) 2008-03-07 2011-09-06 Xerox Corporation Nanosized particles of benzimidazolone pigments
US7938903B2 (en) * 2008-03-07 2011-05-10 Xerox Corporation Nanosized particles of benzimidazolone pigments
US7883574B2 (en) 2008-03-07 2011-02-08 Xerox Corporation Methods of making nanosized particles of benzimidazolone pigments
US7857901B2 (en) * 2008-03-07 2010-12-28 Xerox Corporation Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments
US8025723B2 (en) 2008-03-07 2011-09-27 Xerox Corporation Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments
US7905954B2 (en) * 2008-03-07 2011-03-15 Xerox Corporation Nanosized particles of benzimidazolone pigments
US7985290B2 (en) * 2008-03-07 2011-07-26 Xerox Corporation Nonpolar liquid and solid phase change ink compositions comprising nanosized particles of benzimidazolone pigments
ES2436195T3 (es) 2008-06-16 2013-12-27 Merck Patent Gmbh Derivados de la quinoxalinadiona
WO2009087242A2 (en) 2009-04-09 2009-07-16 Symrise Gmbh & Co. Kg Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent
US8703988B2 (en) 2010-06-22 2014-04-22 Xerox Corporation Self-assembled nanostructures
US8362270B2 (en) 2010-05-11 2013-01-29 Xerox Corporation Self-assembled nanostructures
EP2322512B1 (en) 2009-10-19 2015-10-21 Xerox Corporation Alkylated benzimidazolone compounds and self-assembled nanostructures generated therefrom
PL2858989T3 (pl) * 2012-05-17 2020-11-16 Genentech, Inc. Amorficzna postać inhibującego AKT związku pirymidynylo-cyklopentanu, kompozycje oraz ich sposoby
CN103923033B (zh) * 2013-01-14 2015-11-18 天津药物研究院 具有抗胃溃疡作用的哌嗪类衍生物
WO2016179157A1 (en) 2015-05-05 2016-11-10 Carafe Drug Innovation, Llc Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
CN108863949B (zh) * 2018-07-09 2021-01-15 湖南博隽生物医药有限公司 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法
AR128577A1 (es) * 2022-03-01 2024-05-22 Syngenta Crop Protection Ag Compuestos herbicidas

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725600A (en) 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US5272167A (en) * 1986-12-10 1993-12-21 Schering Corporation Pharmaceutically active compounds
US5750532A (en) * 1986-12-10 1998-05-12 Schering Corporation Pharmaceutically active compounds
CA2090027A1 (en) 1990-08-31 1992-03-01 Shoichi Chokai Pyrimidine derivatives and drugs
DK168780B1 (da) * 1992-04-15 1994-06-06 Celwave R F A S Antennesystem samt fremgangsmåde til fremstilling heraf
IL118469A (en) * 1995-06-15 2000-08-13 Tanabe Seiyaku Co Naphthalene derivatives their preparation and intermediates thereof
KR19990028230A (ko) 1995-06-20 1999-04-15 미리암 디. 메코너헤이 살절지동물성 및 살진균성 시클릭 아미드
ES2100129B1 (es) 1995-10-11 1998-02-16 Medichem Sa Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
CA2252701C (en) * 1996-05-01 2003-10-28 Mississippi State University Halo-substituted protein kinase c inhibitors
CA2266639A1 (en) * 1996-09-23 1998-03-26 Rajeshwar Singh 3,4-disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators
US5916887A (en) 1996-09-23 1999-06-29 National Research Council Of Canada 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators
WO1998023155A1 (en) 1996-11-26 1998-06-04 E.I. Du Pont De Nemours And Company Arthropodicidal and fungicidal cyclic amides
WO1998023156A1 (en) 1996-11-26 1998-06-04 E.I. Du Pont De Nemours And Company Methyl substituted fungicides and arthropodicides
US5932590A (en) 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU6013998A (en) 1996-12-30 1998-07-31 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6093737A (en) * 1996-12-30 2000-07-25 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE59807486D1 (de) * 1997-09-05 2003-04-17 Basf Ag Verfahren zur herstellung (hetero)aromatischer hydroxylamine
CA2260499A1 (en) 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Pharmaceutical compositions for the treatment of ischemic brain damage
AU2428799A (en) 1998-02-13 1999-08-30 Aventis Pharma S.A. Condensed heterocyclic system derivatives, preparation, pharmaceutical compositions containing them
US6306866B1 (en) * 1998-03-06 2001-10-23 American Cyanamid Company Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
AR014975A1 (es) 1998-04-08 2001-04-11 Nps Pharma Inc Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento
AU5574799A (en) * 1998-08-25 2000-03-14 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application
WO2000050398A2 (en) * 1999-02-24 2000-08-31 F. Hoffmann-La Roche Ag Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists
GB9907683D0 (en) 1999-04-06 1999-05-26 Synphar Lab Inc Substituted azetidin-2-ones as cysteine protease inhibitors
EP1219606A4 (en) 1999-07-19 2005-08-31 Shionogi & Co ACYLOXYMETHOXYCARBONYLE PENDANT TRICYCLIC COMPOUNDS
MXPA01013452A (es) 1999-07-23 2002-07-02 Shionogi & Co Inhibodores de diferenciacion th2.
AU6016000A (en) 1999-07-23 2001-02-13 Shionogi & Co., Ltd. Tricyclic compounds and drug compositions containing the same
WO2001014331A2 (en) 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
WO2001019817A2 (en) 1999-09-14 2001-03-22 Abbott Laboratories 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
EA200200688A1 (ru) 2000-01-18 2003-02-27 Пфайзер Продактс Инк. Антагонисты фактора, высвобождающего кортикотропин
US20020002171A1 (en) 2000-01-28 2002-01-03 Chalquest Richard R. Materials and methods for killing nematodes and nematode eggs
KR20030009416A (ko) 2000-04-04 2003-01-29 시오노기세이야쿠가부시키가이샤 고지용성 약물을 함유하는 유성 조성물
AU2001244610A1 (en) 2000-04-05 2001-10-23 Shionogi And Co., Ltd. Oil-in-water microemulsions containing tricyclic compounds or preconcentrates thereof
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
TWI259180B (en) 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
JP2004521077A (ja) 2000-08-30 2004-07-15 ダウ アグロサイエンシィズ エルエルシー 殺虫剤として有用な化合物、殺ダニ剤として有用な化合物およびその使用ならびにその製造方法
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6610677B2 (en) * 2000-09-15 2003-08-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
AU2002214626A1 (en) 2000-09-29 2002-04-08 Cor Therapeutics, Inc. Quaternary amines and related inhibitors of factor xa
DE60134679D1 (de) 2000-10-20 2008-08-14 Eisai R&D Man Co Ltd Stickstoff enthaltende aromatische Heterozyklen
SE0004245D0 (sv) * 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
WO2002050052A1 (en) 2000-12-20 2002-06-27 Syngenta Participations Ag N-acyl aminoacetonitriles having pesticidal properties
WO2002079197A1 (en) 2001-03-29 2002-10-10 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
WO2002080853A2 (en) 2001-04-09 2002-10-17 Bristol-Myers Squibb Company Fused heterocyclic inhibitors of factor xa
KR20040015191A (ko) 2001-04-27 2004-02-18 미쯔비시 웰 파마 가부시키가이샤 신규 벤질피페리딘 화합물
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
MXPA04003170A (es) 2001-10-03 2004-07-08 Pharmacia Corp Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion.
EP1482940A2 (en) 2001-10-03 2004-12-08 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
WO2003029210A2 (en) 2001-10-04 2003-04-10 Merck & Co. Inc. Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5
JP4343690B2 (ja) 2001-11-13 2009-10-14 メルク フロスト カナダ リミテツド プロテアーゼ阻害薬としてのシアノアルキルアミノ誘導体
CA2468544A1 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands
ATE493987T1 (de) * 2002-05-22 2011-01-15 Amgen Inc Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen
US7361665B2 (en) 2002-07-09 2008-04-22 Vertex Pharmaceuticals Incorporated Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
CA2493667C (en) * 2002-08-08 2010-04-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US7419984B2 (en) * 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
GB0226724D0 (en) 2002-11-15 2002-12-24 Merck Sharp & Dohme Therapeutic agents
BRPI0406809A (pt) 2003-01-17 2005-12-27 Warner Lambert Co Heterociclos substituìdos de 2-aminopiridina como inibidores da proliferação celular
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors

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JP2007522235A (ja) 2007-08-09
WO2005077944A1 (en) 2005-08-25
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TW200534858A (en) 2005-11-01
CA2555685A1 (en) 2005-08-25
KR20070033325A (ko) 2007-03-26
BRPI0507927A (pt) 2007-07-17
AR049771A1 (es) 2006-09-06
EA200601426A1 (ru) 2007-02-27
IL177369A0 (en) 2006-12-10
EA010265B1 (ru) 2008-06-30
EP1720868B1 (en) 2009-11-04
MY139645A (en) 2009-10-30
NO20064055L (no) 2006-10-24
ATE447570T1 (de) 2009-11-15
KR100813093B1 (ko) 2008-03-17
CN1953976A (zh) 2007-04-25
US7511044B2 (en) 2009-03-31
US20050176726A1 (en) 2005-08-11
AU2005212517B2 (en) 2009-05-21
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ES2333973T3 (es) 2010-03-03
AU2005212517A1 (en) 2005-08-25

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