ZA200603780B - Compositions and methods for regulation of tumor necrosis factor-alpha - Google Patents

Compositions and methods for regulation of tumor necrosis factor-alpha Download PDF

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Publication number
ZA200603780B
ZA200603780B ZA200603780A ZA200603780A ZA200603780B ZA 200603780 B ZA200603780 B ZA 200603780B ZA 200603780 A ZA200603780 A ZA 200603780A ZA 200603780 A ZA200603780 A ZA 200603780A ZA 200603780 B ZA200603780 B ZA 200603780B
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protein
isoform
seq
antibody
cells
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ZA200603780A
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English (en)
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Kim Soo-Hyun
Charles A Dinarello
Azam Tania
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Univ Colorado
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ZA200603780A 2003-11-12 2006-05-11 Compositions and methods for regulation of tumor necrosis factor-alpha ZA200603780B (en)

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US51981803P 2003-11-12 2003-11-12

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ZA200603780B true ZA200603780B (en) 2007-06-27

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US (4) US7560265B2 (enExample)
EP (2) EP2357238A3 (enExample)
JP (2) JP4979385B2 (enExample)
CN (1) CN101018808B (enExample)
AU (1) AU2004290049B2 (enExample)
BR (1) BRPI0416467A (enExample)
CA (1) CA2545359C (enExample)
EA (1) EA012567B1 (enExample)
IL (1) IL175503A0 (enExample)
MX (1) MXPA06005219A (enExample)
WO (1) WO2005047478A2 (enExample)
ZA (1) ZA200603780B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4979385B2 (ja) * 2003-11-12 2012-07-18 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト 腫瘍壊死因子αの調節のための組成物及び方法
IL169622A0 (en) * 2005-07-11 2007-07-04 Yeda Res & Dev Methods of screening modulators of interleukin-32 (il-32)modulators of il-32 identified by said methods and their use
KR100855299B1 (ko) * 2007-02-16 2008-08-29 건국대학교 산학협력단 인간 il-32 특이 항원결정기를 갖는 단일클론항체,특이항체분비 융합 세포주 및 항체들을 이용한 il-32측정법
US20090263377A1 (en) * 2008-04-10 2009-10-22 Charles Lin Il-32b-targeted diagnosis and therapy
JP5395725B2 (ja) * 2010-04-05 2014-01-22 富士フイルム株式会社 電子内視鏡システム
WO2012142597A1 (en) * 2011-04-15 2012-10-18 The Regents Of The University Of California A method for generating potent dendritic cells
US9273284B2 (en) 2011-04-19 2016-03-01 The Regents Of The University Of California Method for generating potent dendritic cells
CN102392043A (zh) * 2011-12-13 2012-03-28 江南大学 毕赤酵母制备人白细胞介素32β的方法
CN102660552B (zh) * 2011-12-30 2014-03-19 西北农林科技大学 一种牛白细胞介素32γ亚型的分子克隆/稳转细胞系的建立及其方法
WO2015001010A1 (en) 2013-07-03 2015-01-08 Immunoqure Ag Human anti-il-32 antibodies
CN104975041B (zh) * 2014-12-19 2018-01-23 中山大学 一种促进单核细胞向巨噬细胞分化的方法
KR101693275B1 (ko) 2015-03-03 2017-01-05 충북대학교 산학협력단 IFN-γ 및 IL-32γ를 유효성분으로 포함하는 항암용 조성물
GB201701404D0 (en) * 2017-01-27 2017-03-15 Micropharm Ltd Therapies for treating inflammatory disorders
US20200264192A1 (en) * 2017-09-28 2020-08-20 Turun Yliopisto Interleukin 32 as a biomarker of type 1 diabetes
WO2025137261A1 (en) * 2023-12-20 2025-06-26 Verily Life Sciences Llc Methods of diagnosing and treating rheumatoid arthritis by identifying inflammatory initiators

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6448380B2 (en) 1989-08-07 2002-09-10 Peptech Limited Tumor necrosis factor antibodies
NZ235148A (en) 1989-09-05 1991-12-23 Immunex Corp Tumour necrosis factor receptor protein and dna sequences
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
US6706491B1 (en) 1999-04-09 2004-03-16 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by p21
AU4347701A (en) 2000-03-01 2001-09-12 Corixa Corp Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
EP1341804A4 (en) * 2000-11-17 2005-08-24 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
WO2002048310A2 (en) 2000-12-15 2002-06-20 Genetics Institute, Llc Methods and compositions for diagnosing and treating rheumatoid arthritis
IL158397A0 (en) 2001-04-18 2004-05-12 Genset Sa Polypeptides, their preparation and their use
US20030092616A1 (en) 2001-05-25 2003-05-15 Akio Matsuda STAT6 activation gene
AU2001286171B2 (en) 2001-05-25 2008-01-10 Serono Genetics Institute S.A. Human CDNAs and proteins and uses thereof
WO2002096943A1 (en) 2001-05-25 2002-12-05 Asahi Kasei Kabushiki Kaisha Stat6-activating genes
WO2002101075A2 (en) 2001-06-13 2002-12-19 Millennium Pharmaceuticals, Inc. Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
US20030073623A1 (en) * 2001-07-30 2003-04-17 Drmanac Radoje T. Novel nucleic acid sequences obtained from various cDNA libraries
WO2003012061A2 (en) 2001-08-01 2003-02-13 Coley Pharmaceutical Gmbh Methods and compositions relating to plasmacytoid dendritic cells
JP2005514917A (ja) 2001-10-03 2005-05-26 インサイト・ゲノミックス・インコーポレイテッド 分泌タンパク質
WO2003080640A1 (en) 2002-03-07 2003-10-02 Ludwig Institute For Cancer Research Lymphatic and blood endothelial cell genes
JP2004121218A (ja) 2002-08-06 2004-04-22 Jenokkusu Soyaku Kenkyusho:Kk 気管支喘息または慢性閉塞性肺疾患の検査方法
US20050048490A1 (en) 2002-09-26 2005-03-03 Incyte Corp. Proteins associated with cell growth, differentiation, and death
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP4979385B2 (ja) * 2003-11-12 2012-07-18 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト 腫瘍壊死因子αの調節のための組成物及び方法
KR100565698B1 (ko) 2004-12-29 2006-03-28 디지탈 지노믹스(주) 급성골수성백혈병(aml), b-세포형 급성임파구성백혈병(b-all), t 세포형 급성임파구성백혈병(t-all) 진단용 마커
KR100855299B1 (ko) * 2007-02-16 2008-08-29 건국대학교 산학협력단 인간 il-32 특이 항원결정기를 갖는 단일클론항체,특이항체분비 융합 세포주 및 항체들을 이용한 il-32측정법

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Publication number Publication date
EP2357238A3 (en) 2012-02-01
US20110190476A1 (en) 2011-08-04
EP1692175A4 (en) 2008-09-17
CA2545359A1 (en) 2005-05-26
EA012567B1 (ru) 2009-10-30
EP2357238A2 (en) 2011-08-17
WO2005047478A3 (en) 2006-06-01
CN101018808B (zh) 2014-07-23
BRPI0416467A (pt) 2007-03-06
AU2004290049A1 (en) 2005-05-26
US20070071719A1 (en) 2007-03-29
US8138312B2 (en) 2012-03-20
JP2007513609A (ja) 2007-05-31
MXPA06005219A (es) 2007-01-19
CA2545359C (en) 2012-11-06
US20120183601A1 (en) 2012-07-19
JP2012050446A (ja) 2012-03-15
EA200600936A1 (ru) 2006-10-27
AU2004290049B2 (en) 2011-09-29
WO2005047478A2 (en) 2005-05-26
IL175503A0 (en) 2006-09-05
EP1692175A2 (en) 2006-08-23
US20140235829A1 (en) 2014-08-21
CN101018808A (zh) 2007-08-15
US7560265B2 (en) 2009-07-14
US8735358B2 (en) 2014-05-27
JP4979385B2 (ja) 2012-07-18

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