ZA200603365B - Device and method for making particles - Google Patents
Device and method for making particles Download PDFInfo
- Publication number
- ZA200603365B ZA200603365B ZA200603365A ZA200603365A ZA200603365B ZA 200603365 B ZA200603365 B ZA 200603365B ZA 200603365 A ZA200603365 A ZA 200603365A ZA 200603365 A ZA200603365 A ZA 200603365A ZA 200603365 B ZA200603365 B ZA 200603365B
- Authority
- ZA
- South Africa
- Prior art keywords
- organic phase
- prepared
- particles
- microparticles
- inlet
- Prior art date
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- 239000002245 particle Substances 0.000 title claims description 121
- 238000000034 method Methods 0.000 title claims description 30
- 239000012074 organic phase Substances 0.000 claims description 140
- 239000011859 microparticle Substances 0.000 claims description 73
- 239000008346 aqueous phase Substances 0.000 claims description 68
- 238000000265 homogenisation Methods 0.000 claims description 64
- 239000000725 suspension Substances 0.000 claims description 62
- 238000002156 mixing Methods 0.000 claims description 49
- 229920000642 polymer Polymers 0.000 claims description 43
- 239000012071 phase Substances 0.000 claims description 42
- 239000002904 solvent Substances 0.000 claims description 41
- 239000000839 emulsion Substances 0.000 claims description 35
- 239000002105 nanoparticle Substances 0.000 claims description 33
- 238000001914 filtration Methods 0.000 claims description 29
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 239000013543 active substance Substances 0.000 claims description 17
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
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Classifications
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- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3131—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
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- B01F35/753—Discharging at the upper side of the receptacle, e.g. by pressurising the liquid in the receptacle or by centrifugal force
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
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- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Colloid Chemistry (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
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| JP (1) | JP2007507339A (ja) |
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| EP2060253A1 (en) * | 2007-11-14 | 2009-05-20 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
| WO2006069419A1 (en) * | 2004-12-31 | 2006-07-06 | Iceutica Pty Ltd | Nanoparticle composition and methods for synthesis thereof |
| ATE522549T1 (de) * | 2006-03-13 | 2011-09-15 | Basf Se | Verfahren zur herstellung von polymeren nanopartikeln |
| US20070298110A1 (en) * | 2006-06-22 | 2007-12-27 | Xerox Corporation | Methods for embedding nanoparticles |
| CA2653384C (en) | 2006-06-30 | 2017-03-14 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
| US20090306339A1 (en) * | 2006-09-19 | 2009-12-10 | Van Boxtel Huibert Albertus | Preparation of Fine Particles |
| JP5076424B2 (ja) | 2006-09-28 | 2012-11-21 | 日油株式会社 | 撹拌処理方法及び撹拌装置 |
| GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
| US8802156B2 (en) | 2007-11-14 | 2014-08-12 | Laboratorios Farmacéuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| EP2213282A1 (en) * | 2009-01-30 | 2010-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Pharmaceutical forms for the release of active compounds |
| JP5713897B2 (ja) * | 2008-07-16 | 2015-05-07 | エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ | 生理活性ペプチドを含有する微粒子を調製するためのプロセス |
| CN101530778B (zh) * | 2009-03-09 | 2011-05-11 | 神农氏奈米科技有限公司 | 液体纳米化装置 |
| BRPI1014275B8 (pt) | 2009-04-24 | 2021-05-25 | Iceutica Pty Ltd | composição que compreende partículas de indometacina dispersas em pelo menos dois materiais de moagem parcialmente moídos |
| JP5791629B2 (ja) * | 2009-12-22 | 2015-10-07 | エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ | 微粒子を調製する乳剤基調プロセス、及び、プロセスで利用されるワークヘッド構造体 |
| DK2526182T3 (da) * | 2010-01-20 | 2017-11-13 | Xyleco Inc | Dispergering af råmaterialer og forarbejdning af materialer |
| DK2790681T4 (da) * | 2011-11-18 | 2023-05-01 | Regeneron Pharma | Fremgangsmåde til fremstilling af en farmaceutisk formulering med langvarig frigivelse omfattende polymercoatede proteinmikropartikler ved anvendelse af spraytørring |
| CN103521149B (zh) * | 2013-10-10 | 2015-11-04 | 南京理工大学 | 含能高分子微球的制备方法 |
| CN104549078B (zh) * | 2013-10-10 | 2016-11-23 | 南京理工大学 | 一种开孔结构含能高分子微球的制备方法 |
| CN103553853B (zh) * | 2013-11-01 | 2016-04-20 | 南京理工大学 | 水溶性氧化剂在含能复合材料中的原位超细化分散方法 |
| CN103787799B (zh) * | 2014-01-22 | 2016-07-06 | 南京理工大学 | 含能高分子微球的连续制备系统及方法 |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| CN106475574B (zh) * | 2016-11-30 | 2018-06-08 | 燕山大学 | 一种制备金纳米花的方法 |
| CN112587505A (zh) * | 2020-10-16 | 2021-04-02 | 长春斯菲尔生物科技有限公司 | 一种奥氮平双羟萘酸盐缓释微粒制剂及其制备方法 |
| US20220362323A1 (en) * | 2021-05-02 | 2022-11-17 | Kula Llc | Systems and methods for producing a kava liquid dietary supplement |
| US11801514B1 (en) | 2023-02-10 | 2023-10-31 | CR Nano, Inc. | Mechanochemical production of tunable planar materials |
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| US2641453A (en) * | 1951-04-21 | 1953-06-09 | Nat Gypsum Co | Pin mixer |
| JPS5323382B2 (ja) * | 1972-07-03 | 1978-07-14 | ||
| DE2516561C3 (de) * | 1975-04-16 | 1979-10-11 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Fibrillen aus Polymerisaten |
| US4141957A (en) * | 1976-06-29 | 1979-02-27 | Isovolta Osterreichische Isolierstoffwerke Aktiengesellschaft | Apparatus for producing polymers of high molecular weight by the two-phase interfacial method |
| SE445052C (sv) * | 1980-03-13 | 1987-11-09 | Sunds Defibrator | Sett och anordning for kontinuerlig inblandning av gas- och/eller vetskeformiga behandlingsmedel i en massasuspension |
| US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| FI61814C (fi) * | 1980-07-22 | 1982-10-11 | Finnreg Oy | Emulgeringsanordning |
| WO1993010665A1 (en) * | 1991-12-03 | 1993-06-10 | Niro A/S | Process for producing a solid water-in-oil emulsion and an apparatus for carrying out the process |
| DE19616010C2 (de) * | 1996-04-23 | 1998-07-09 | Seitz Filter Werke | Verfahren und Vorrichtung zur Herstellung von Fibrets (Fibriden) aus Zellulosederivaten |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| JP3255072B2 (ja) * | 1997-02-17 | 2002-02-12 | 日本ピー・エム・シー株式会社 | ロジン系物質の水性エマルションの製造方法、その水性エマルション組成物及びサイズ剤 |
| JP4587111B2 (ja) * | 2000-04-06 | 2010-11-24 | 栗田工業株式会社 | オゾン溶解水供給装置 |
| WO2003033097A2 (en) * | 2001-10-17 | 2003-04-24 | E.I. Du Pont De Nemours And Company | Rotor-stator apparatus and process for the formation of particles |
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- 2004-09-28 KR KR1020067006288A patent/KR20060104989A/ko active IP Right Grant
- 2004-09-28 ES ES04769494T patent/ES2286674T3/es active Active
- 2004-09-28 MX MXPA06003599A patent/MXPA06003599A/es active IP Right Grant
- 2004-09-28 DK DK04769494T patent/DK1667790T3/da active
- 2004-09-28 BR BRPI0414982-3A patent/BRPI0414982A/pt not_active IP Right Cessation
- 2004-09-28 US US10/574,003 patent/US20070071825A1/en not_active Abandoned
- 2004-09-28 EP EP04769494A patent/EP1667790B1/fr active Active
- 2004-09-28 AU AU2004277750A patent/AU2004277750B9/en not_active Ceased
-
2006
- 2006-03-30 IL IL174668A patent/IL174668A/en not_active IP Right Cessation
- 2006-04-26 ZA ZA200603365A patent/ZA200603365B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004006523T2 (de) | 2008-01-31 |
| ATE362395T1 (de) | 2007-06-15 |
| DE602004006523D1 (de) | 2007-06-28 |
| WO2005032703A1 (fr) | 2005-04-14 |
| MXPA06003599A (es) | 2006-06-20 |
| AU2004277750A1 (en) | 2005-04-14 |
| CN1863588A (zh) | 2006-11-15 |
| US20070071825A1 (en) | 2007-03-29 |
| AU2004277750B9 (en) | 2010-07-15 |
| KR20060104989A (ko) | 2006-10-09 |
| AU2004277750B2 (en) | 2010-03-11 |
| IL174668A0 (en) | 2006-08-20 |
| CA2539303A1 (fr) | 2005-04-14 |
| CN100534597C (zh) | 2009-09-02 |
| CA2539303C (fr) | 2012-07-17 |
| BRPI0414982A (pt) | 2006-11-21 |
| IL174668A (en) | 2010-12-30 |
| JP2007507339A (ja) | 2007-03-29 |
| ES2286674T3 (es) | 2007-12-01 |
| DK1667790T3 (da) | 2007-09-24 |
| EP1667790A1 (fr) | 2006-06-14 |
| EP1667790B1 (fr) | 2007-05-16 |
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