ZA200602940B - The use of urocanic acid being able to acidify the cell cytoplasm and for preventing or halting cellular proliferation in a person - Google Patents
The use of urocanic acid being able to acidify the cell cytoplasm and for preventing or halting cellular proliferation in a person Download PDFInfo
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- ZA200602940B ZA200602940B ZA200602940A ZA200602940A ZA200602940B ZA 200602940 B ZA200602940 B ZA 200602940B ZA 200602940 A ZA200602940 A ZA 200602940A ZA 200602940 A ZA200602940 A ZA 200602940A ZA 200602940 B ZA200602940 B ZA 200602940B
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- DANUORFCFTYTSZ-BIBFWWMMSA-N nigericin Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)C2O[C@@](C)(CC2)C2[C@H](CC(O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-BIBFWWMMSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940049953 phenylacetate Drugs 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 229950009215 phenylbutanoic acid Drugs 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 150000007519 polyprotic acids Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 102220013998 rs146502276 Human genes 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- ICSAXRANXQSPQP-VUKDEKJYSA-M sodium;(5r,6s)-6-[(1r)-1-hydroxyethyl]-7-oxo-3-[(2r)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate Chemical compound [Na+].S([C@@H]1[C@H](C(N1C=1C([O-])=O)=O)[C@H](O)C)C=1[C@H]1CCCO1 ICSAXRANXQSPQP-VUKDEKJYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- -1 solwations Substances 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- BGRJTUBHPOOWDU-UHFFFAOYSA-N sulpiride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-UHFFFAOYSA-N 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20031793A FI20031793A0 (fi) | 2003-12-09 | 2003-12-09 | Uusi anti-proliferatiivinen farmaseuttinen koostumus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200602940B true ZA200602940B (en) | 2007-07-25 |
Family
ID=29763491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200602940A ZA200602940B (en) | 2003-12-09 | 2004-11-26 | The use of urocanic acid being able to acidify the cell cytoplasm and for preventing or halting cellular proliferation in a person |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20060189691A1 (zh) |
| EP (1) | EP1691805B1 (zh) |
| JP (1) | JP4825680B2 (zh) |
| CN (1) | CN1889950B (zh) |
| AT (1) | ATE396723T1 (zh) |
| AU (1) | AU2004296570B2 (zh) |
| CA (1) | CA2544720C (zh) |
| CY (1) | CY1108163T1 (zh) |
| DE (1) | DE602004014187D1 (zh) |
| DK (1) | DK1691805T3 (zh) |
| ES (1) | ES2303113T3 (zh) |
| FI (1) | FI20031793A0 (zh) |
| PL (1) | PL1691805T3 (zh) |
| PT (1) | PT1691805E (zh) |
| SI (1) | SI1691805T1 (zh) |
| WO (1) | WO2005056007A1 (zh) |
| ZA (1) | ZA200602940B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20030379A0 (fi) * | 2003-03-14 | 2003-03-14 | Lasse Leino | Uusi farmaseuttinen koostumus |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE126058T1 (de) * | 1990-06-29 | 1995-08-15 | Bode Chemie Gmbh & Co | Dermatologische zusammensetzungen mit einem gehalt an cis-urocaninsäure. |
| US5455036A (en) * | 1990-06-29 | 1995-10-03 | Bode Chemie | Method of using cis-urocaninic acid for topically treating psoriasis |
| DE4122497C2 (de) | 1991-07-02 | 1998-03-26 | Wogepharm Gmbh | Verwendung von trans-Urokaninsäure bei der prophylaktischen Therapie der Psoriasis |
| US5843979A (en) * | 1993-02-25 | 1998-12-01 | Bristol-Myers Squibb Company | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
| CA2114968A1 (en) * | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
| GB9306473D0 (en) * | 1993-03-29 | 1993-05-19 | Bioglan Lab Ltd | Pharmaceutically useful compounds |
| US5686100A (en) * | 1994-11-22 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Prophylactic and therapeutic treatment of skin sensitization and irritation |
| US5576013A (en) * | 1995-03-21 | 1996-11-19 | Eastern Virginia Medical School | Treating vascular and neoplastic tissues |
| WO1997047355A1 (en) * | 1996-06-12 | 1997-12-18 | Alza Corporation | Reduction of skin sensitization in electrotransport drug delivery |
| DE19638064C2 (de) * | 1996-09-18 | 1998-08-20 | Voith Turbo Kg | Verfahren zur Steuerung von Schaltvorgängen bei einem Fahrzeuggetriebe |
| DE19817295A1 (de) * | 1998-04-18 | 1999-10-21 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an unsymmetrisch substituiertenTriazinderivaten zum Erhalt des Urocaninsäurestatus der Haut |
| US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
| JP2003530850A (ja) * | 2000-04-14 | 2003-10-21 | ユニバーシティー オブ サウス カロライナ リサーチ ファウンデーション | 生物活性ヒスチジンアンモニアリアーゼのクローニング、過剰発現および治療用途 |
| US6582734B1 (en) | 2000-07-20 | 2003-06-24 | Ecolab Inc. | Antimicrobial composition useful for the treatment of bovine mastitis |
| US6541509B2 (en) * | 2000-09-15 | 2003-04-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method for treating neoplasia using combination chemotherapy |
| FI20030379A0 (fi) * | 2003-03-14 | 2003-03-14 | Lasse Leino | Uusi farmaseuttinen koostumus |
-
2003
- 2003-12-09 FI FI20031793A patent/FI20031793A0/fi not_active Application Discontinuation
-
2004
- 2004-11-26 DK DK04798326T patent/DK1691805T3/da active
- 2004-11-26 SI SI200430757T patent/SI1691805T1/sl unknown
- 2004-11-26 US US10/565,202 patent/US20060189691A1/en not_active Abandoned
- 2004-11-26 AU AU2004296570A patent/AU2004296570B2/en not_active Ceased
- 2004-11-26 ZA ZA200602940A patent/ZA200602940B/en unknown
- 2004-11-26 CN CN2004800362562A patent/CN1889950B/zh not_active Expired - Fee Related
- 2004-11-26 CA CA2544720A patent/CA2544720C/en not_active Expired - Fee Related
- 2004-11-26 JP JP2006543562A patent/JP4825680B2/ja not_active Expired - Fee Related
- 2004-11-26 PT PT04798326T patent/PT1691805E/pt unknown
- 2004-11-26 WO PCT/FI2004/000717 patent/WO2005056007A1/en active Search and Examination
- 2004-11-26 DE DE602004014187T patent/DE602004014187D1/de active Active
- 2004-11-26 EP EP04798326A patent/EP1691805B1/en not_active Not-in-force
- 2004-11-26 ES ES04798326T patent/ES2303113T3/es active Active
- 2004-11-26 PL PL04798326T patent/PL1691805T3/pl unknown
- 2004-11-26 AT AT04798326T patent/ATE396723T1/de active
-
2006
- 2006-04-21 US US11/408,056 patent/US8338475B2/en not_active Expired - Fee Related
-
2008
- 2008-06-30 CY CY20081100681T patent/CY1108163T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2544720A1 (en) | 2005-06-23 |
| US20060189692A1 (en) | 2006-08-24 |
| CN1889950A (zh) | 2007-01-03 |
| EP1691805A1 (en) | 2006-08-23 |
| CN1889950B (zh) | 2011-02-09 |
| AU2004296570A1 (en) | 2005-06-23 |
| CA2544720C (en) | 2012-01-03 |
| US20060189691A1 (en) | 2006-08-24 |
| ATE396723T1 (de) | 2008-06-15 |
| CY1108163T1 (el) | 2014-02-12 |
| JP4825680B2 (ja) | 2011-11-30 |
| PL1691805T3 (pl) | 2008-11-28 |
| DE602004014187D1 (de) | 2008-07-10 |
| AU2004296570B2 (en) | 2011-01-06 |
| FI20031793A0 (fi) | 2003-12-09 |
| WO2005056007A1 (en) | 2005-06-23 |
| PT1691805E (pt) | 2008-06-12 |
| EP1691805B1 (en) | 2008-05-28 |
| ES2303113T3 (es) | 2008-08-01 |
| DK1691805T3 (da) | 2008-10-06 |
| JP2007513927A (ja) | 2007-05-31 |
| SI1691805T1 (sl) | 2008-08-31 |
| US8338475B2 (en) | 2012-12-25 |
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