ZA200602387B - 6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents - Google Patents

6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents

Info

Publication number
ZA200602387B
ZA200602387B ZA200602387A ZA200602387A ZA200602387B ZA 200602387 B ZA200602387 B ZA 200602387B ZA 200602387 A ZA200602387 A ZA 200602387A ZA 200602387 A ZA200602387 A ZA 200602387A ZA 200602387 B ZA200602387 B ZA 200602387B
Authority
ZA
South Africa
Prior art keywords
triazolopyrimidines
phenyl
substituted
anticancer agents
anticancer
Prior art date
Application number
ZA200602387A
Other languages
English (en)
Inventor
Zhang Nan
Nguyen Thai Hiep
Tong Wei
Ayral-Kaloustian Semiramis
Wu Yanzhong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200602387B publication Critical patent/ZA200602387B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200602387A 2003-09-24 2006-03-23 6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents ZA200602387B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
ZA200602387B true ZA200602387B (en) 2008-11-26

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200602387A ZA200602387B (en) 2003-09-24 2006-03-23 6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents

Country Status (31)

Country Link
US (1) US7507739B2 (de)
EP (1) EP1680425B1 (de)
JP (1) JP2007506744A (de)
KR (1) KR20060098368A (de)
CN (1) CN100519559C (de)
AR (1) AR045810A1 (de)
AU (1) AU2004276240A1 (de)
BR (1) BRPI0414700A (de)
CA (1) CA2539252A1 (de)
CO (1) CO5690598A2 (de)
CR (1) CR8288A (de)
CY (1) CY1106392T1 (de)
DE (1) DE602004004295T8 (de)
DK (1) DK1680425T3 (de)
EC (1) ECSP066458A (de)
ES (1) ES2279452T3 (de)
GT (1) GT200400190A (de)
HK (1) HK1090374A1 (de)
IL (1) IL174281A0 (de)
MX (1) MXPA06003206A (de)
NO (1) NO20061318L (de)
PA (1) PA8613301A1 (de)
PE (1) PE20050433A1 (de)
PL (1) PL1680425T3 (de)
PT (1) PT1680425E (de)
RU (1) RU2006107579A (de)
SA (1) SA04250302A (de)
SI (1) SI1680425T1 (de)
TW (1) TW200512211A (de)
WO (1) WO2005030775A1 (de)
ZA (1) ZA200602387B (de)

Families Citing this family (14)

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CA2413802A1 (en) * 2000-06-30 2002-01-10 Mark R. Schmitt Substituted-triazolopyrimidines as anticancer agents
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
AU2006259663A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
BRPI0612676A2 (pt) * 2005-06-27 2016-11-29 Basf Ag processo para preparar compostos, compostos, e, uso de compostos
BRPI0619962A2 (pt) * 2005-12-16 2011-10-25 Wyeth Corp composições liofilizadas de um composto triazolopirimidina
CN101370813A (zh) * 2005-12-16 2009-02-18 惠氏公司 用作抗癌药物的6-[(取代的)苯基]三唑并嘧啶类的二聚体和加合物
JP2010515669A (ja) * 2007-01-08 2010-05-13 ビーエーエスエフ ソシエタス・ヨーロピア 有害な植物病原菌類を防除するためのアゾロピリミジンの使用
WO2014047257A2 (en) 2012-09-19 2014-03-27 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
EP3758696A4 (de) * 2018-03-02 2021-12-08 The Trustees of the University of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidin-verbindungen und verwendung davon zur stabilisierung von mikrotubuli
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
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RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
AU6558498A (en) 1997-03-18 1998-10-12 American Cyanamid Company Process for the preparation of arylmalonates
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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
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JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
EP1066291B8 (de) 1998-03-23 2005-09-14 Basf Aktiengesellschaft Fungizide 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidine
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
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US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
RU2224434C2 (ru) 1998-09-25 2004-02-27 Басф Аг Безводный стабильный концентрат и способ его получения
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
ATE240648T1 (de) 1998-09-25 2003-06-15 Basf Ag Fungizide mischungen
US6521628B1 (en) * 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) * 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
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US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
CA2413802A1 (en) * 2000-06-30 2002-01-10 Mark R. Schmitt Substituted-triazolopyrimidines as anticancer agents
SK3522003A3 (en) * 2000-08-25 2003-08-05 Basf Ag Fungicidal formulation
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
AU2002221831A1 (en) 2000-11-13 2002-05-21 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidines, the production thereof and use of the same for combating phytopathogenic fungi
ATE273981T1 (de) 2000-12-06 2004-09-15 Basf Ag Fungiizide 6-(trifluormethyl-phenyl)- triazolpyrimidine
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ATE287405T1 (de) 2001-04-11 2005-02-15 Wyeth Corp 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
DE10124208A1 (de) * 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
JP2005504743A (ja) 2001-07-18 2005-02-17 ビーエーエスエフ アクチェンゲゼルシャフト 殺菌薬としての置換された６−（２−メトキシ−フェニル）−トリアゾロピリミジン
JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類

Also Published As

Publication number Publication date
ECSP066458A (es) 2006-09-18
CY1106392T1 (el) 2011-10-12
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
BRPI0414700A (pt) 2006-11-14
GT200400190A (es) 2005-05-02
CR8288A (es) 2006-10-04
US7507739B2 (en) 2009-03-24
WO2005030775A1 (en) 2005-04-07
KR20060098368A (ko) 2006-09-18
EP1680425A1 (de) 2006-07-19
SI1680425T1 (sl) 2007-04-30
JP2007506744A (ja) 2007-03-22
DK1680425T3 (da) 2007-03-19
CO5690598A2 (es) 2006-10-31
PA8613301A1 (es) 2005-11-25
AR045810A1 (es) 2005-11-16
CA2539252A1 (en) 2005-04-07
DE602004004295T8 (de) 2007-09-20
RU2006107579A (ru) 2007-10-27
ES2279452T3 (es) 2007-08-16
PT1680425E (pt) 2007-02-28
TW200512211A (en) 2005-04-01
CN1867569A (zh) 2006-11-22
IL174281A0 (en) 2006-08-01
HK1090374A1 (en) 2006-12-22
NO20061318L (no) 2006-04-21
US20050090508A1 (en) 2005-04-28
DE602004004295T2 (de) 2007-06-06
DE602004004295D1 (de) 2007-02-22
EP1680425B1 (de) 2007-01-10
MXPA06003206A (es) 2006-06-23
AU2004276240A1 (en) 2005-04-07
CN100519559C (zh) 2009-07-29
PE20050433A1 (es) 2005-07-21

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