ZA200600419B - Indol-6 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators - Google Patents
Indol-6 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators Download PDFInfo
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- ZA200600419B ZA200600419B ZA200600419A ZA200600419A ZA200600419B ZA 200600419 B ZA200600419 B ZA 200600419B ZA 200600419 A ZA200600419 A ZA 200600419A ZA 200600419 A ZA200600419 A ZA 200600419A ZA 200600419 B ZA200600419 B ZA 200600419B
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- 238000002360 preparation method Methods 0.000 title description 3
- AFJYOUBTIAOUQI-UHFFFAOYSA-N 1h-indole-6-sulfonamide Chemical class NS(=O)(=O)C1=CC=C2C=CNC2=C1 AFJYOUBTIAOUQI-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 100
- -1 sulfonamide compound Chemical class 0.000 claims description 95
- 229910052739 hydrogen Inorganic materials 0.000 claims description 73
- 239000001257 hydrogen Substances 0.000 claims description 73
- 239000003814 drug Substances 0.000 claims description 68
- 238000011282 treatment Methods 0.000 claims description 67
- 238000011321 prophylaxis Methods 0.000 claims description 66
- 238000004519 manufacturing process Methods 0.000 claims description 58
- 125000005842 heteroatom Chemical group 0.000 claims description 50
- 229920006395 saturated elastomer Polymers 0.000 claims description 49
- 150000003254 radicals Chemical class 0.000 claims description 45
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 125000002950 monocyclic group Chemical group 0.000 claims description 29
- 208000035475 disorder Diseases 0.000 claims description 26
- 150000002431 hydrogen Chemical class 0.000 claims description 25
- 229940124530 sulfonamide Drugs 0.000 claims description 21
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 16
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- 125000002619 bicyclic group Chemical group 0.000 claims description 13
- 229910052801 chlorine Inorganic materials 0.000 claims description 13
- 239000000460 chlorine Substances 0.000 claims description 13
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- 238000000034 method Methods 0.000 claims description 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 11
- 125000004450 alkenylene group Chemical group 0.000 claims description 11
- 125000004419 alkynylene group Chemical group 0.000 claims description 11
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 10
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 claims 2
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- MIMYTSWNVBMNRH-UHFFFAOYSA-N 1h-indol-6-amine Chemical compound NC1=CC=C2C=CNC2=C1 MIMYTSWNVBMNRH-UHFFFAOYSA-N 0.000 claims 1
- PHDLHKXIMTZUKZ-UHFFFAOYSA-N 3,5-dichloro-n-[1-[2-(dimethylamino)ethyl]indol-6-yl]benzenesulfonamide Chemical compound C1=C2N(CCN(C)C)C=CC2=CC=C1NS(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 PHDLHKXIMTZUKZ-UHFFFAOYSA-N 0.000 claims 1
- YJKGUHLFARNGHG-UHFFFAOYSA-N 4-phenoxy-n-[1-(2-pyrrolidin-1-ylethyl)indol-6-yl]benzenesulfonamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1S(=O)(=O)NC(C=C12)=CC=C1C=CN2CCN1CCCC1 YJKGUHLFARNGHG-UHFFFAOYSA-N 0.000 claims 1
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- 150000008050 dialkyl sulfates Chemical class 0.000 claims 1
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- YBMWPCIPYFXGAM-UHFFFAOYSA-N n-[1-[2-(dimethylamino)ethyl]indol-6-yl]-2-naphthalen-1-ylethanesulfonamide Chemical compound C1=CC=C2C(CCS(=O)(=O)NC3=CC=C4C=CN(C4=C3)CCN(C)C)=CC=CC2=C1 YBMWPCIPYFXGAM-UHFFFAOYSA-N 0.000 claims 1
- AUIIXCCJDYHWEM-UHFFFAOYSA-N n-[1-[2-(dimethylamino)ethyl]indol-6-yl]-4-phenoxybenzenesulfonamide Chemical compound C1=C2N(CCN(C)C)C=CC2=CC=C1NS(=O)(=O)C(C=C1)=CC=C1OC1=CC=CC=C1 AUIIXCCJDYHWEM-UHFFFAOYSA-N 0.000 claims 1
- MMVUKQDPMLJEFQ-UHFFFAOYSA-N n-[1-[2-(dimethylamino)ethyl]indol-6-yl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NC3=CC=C4C=CN(C4=C3)CCN(C)C)=CC=CC2=C1 MMVUKQDPMLJEFQ-UHFFFAOYSA-N 0.000 claims 1
- GLMWOXAKQHRWJX-UHFFFAOYSA-N n-[1-[2-(dimethylamino)ethyl]indol-6-yl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NC3=CC=C4C=CN(C4=C3)CCN(C)C)=CC=C21 GLMWOXAKQHRWJX-UHFFFAOYSA-N 0.000 claims 1
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200301810A ES2222832B1 (es) | 2003-07-30 | 2003-07-30 | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
Publications (1)
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|---|---|
| ZA200600419B true ZA200600419B (en) | 2007-03-28 |
Family
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Family Applications (1)
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| ZA200600419A ZA200600419B (en) | 2003-07-30 | 2004-07-29 | Indol-6 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators |
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| US (1) | US7462640B2 (no) |
| EP (1) | EP1660077B1 (no) |
| JP (1) | JP2007500164A (no) |
| KR (1) | KR20060123699A (no) |
| CN (1) | CN100563650C (no) |
| AR (1) | AR045155A1 (no) |
| AT (1) | ATE432701T1 (no) |
| AU (1) | AU2004262484A1 (no) |
| BR (1) | BRPI0413112A (no) |
| CA (1) | CA2533970A1 (no) |
| DE (1) | DE602004021394D1 (no) |
| ES (2) | ES2222832B1 (no) |
| IL (1) | IL172894A0 (no) |
| MX (1) | MXPA06001141A (no) |
| NO (1) | NO20060682L (no) |
| NZ (1) | NZ545301A (no) |
| PE (1) | PE20050280A1 (no) |
| PT (1) | PT1660077E (no) |
| RU (1) | RU2006105777A (no) |
| TW (1) | TW200509907A (no) |
| WO (1) | WO2005013976A1 (no) |
| ZA (1) | ZA200600419B (no) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2222832B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
| ES2246721B1 (es) * | 2004-08-10 | 2007-03-16 | Laboratorios Del Dr. Esteve, S.A. | Compuestos indolicos sustituidos, su preparacion y su uso como medicamentos. |
| EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
| KR20080039982A (ko) * | 2005-08-25 | 2008-05-07 | 쉐링 코포레이션 | 작용 선택적 알파2ｃ 아드레날린성 수용체 효능제로서의이미다졸 유도체 |
| CA2637933C (en) * | 2006-01-24 | 2013-03-12 | Eli Lilly And Company | Indole sulfonamide modulators of progesterone receptors |
| EP1953153A1 (en) * | 2007-01-31 | 2008-08-06 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders |
| DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2018861A1 (en) * | 2007-07-26 | 2009-01-28 | Laboratorios del Dr. Esteve S.A. | 5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE602007012080D1 (de) | 2007-08-01 | 2011-03-03 | Esteve Labor Dr | Kombination von mindestens zwei 5-HT6-Liganden |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2053052A1 (en) | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
| EP2116547A1 (en) * | 2008-05-09 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands |
| US8309746B2 (en) | 2008-06-06 | 2012-11-13 | Harbor Therapeutics, Inc | Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds |
| ITMC20080120A1 (it) * | 2008-06-20 | 2009-12-21 | Nazario Luzi | Sistema di ripresa video in particolare per la pesca. |
| EP2149573A1 (en) * | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | Substituted indole sulfonamide compounds their preparation and use as medicaments |
| US20190336585A1 (en) * | 2018-05-03 | 2019-11-07 | John Lawrence Mee | Method for sustainable human cognitive enhancement |
| US20190390193A1 (en) * | 2018-06-23 | 2019-12-26 | John Lawrence Mee | Reversible method for sustainable human cognitive enhancement |
| RS65335B1 (sr) | 2018-10-05 | 2024-04-30 | Annapurna Bio Inc | Jedinjenja i kompozicije za lečenje stanja povezanih sa aktivnošću receptora apj |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472870A (en) * | 1966-08-29 | 1969-10-14 | Mead Johnson & Co | Sulfonamidotryptamines |
| WO1995032967A1 (en) | 1994-05-28 | 1995-12-07 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
| JPH11502816A (ja) | 1995-03-20 | 1999-03-09 | イーライ・リリー・アンド・カンパニー | ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト |
| DE19625184B4 (de) | 1996-06-24 | 2005-06-30 | Wabag Wassertechnik Gmbh | Verfahren zur Aufbereitung von Prozeßwasser aus einer Flaschenreinigungsmaschine |
| US5939451A (en) | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
| DE19753522A1 (de) * | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| ES2272667T3 (es) * | 2001-01-30 | 2007-05-01 | Eli Lilly And Company | Indol-5-il esteres del acido bencenosulfonico como antagonistas de receptor 5-ht6. |
| ES2187300B1 (es) * | 2001-11-14 | 2004-06-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2313002T3 (es) * | 2003-05-09 | 2009-03-01 | Laboratorios Del Dr. Esteve, S.A. | Uso de derivados de sulfonamida para la fabricacion de un medicamento para la profilaxis y/o tratamiento de la ingestion de alimentos. |
| WO2004108564A1 (ja) * | 2003-06-02 | 2004-12-16 | Kabushiki Kaisha Marifit | コンテナ連結金具 |
| ES2222832B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
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2003
- 2003-07-30 ES ES200301810A patent/ES2222832B1/es not_active Expired - Fee Related
-
2004
- 2004-07-29 ES ES04741319T patent/ES2327845T3/es active Active
- 2004-07-29 WO PCT/EP2004/008510 patent/WO2005013976A1/en active Application Filing
- 2004-07-29 TW TW093122667A patent/TW200509907A/zh unknown
- 2004-07-29 AR ARP040102697A patent/AR045155A1/es unknown
- 2004-07-29 CA CA002533970A patent/CA2533970A1/en not_active Abandoned
- 2004-07-29 JP JP2006521528A patent/JP2007500164A/ja active Pending
- 2004-07-29 ZA ZA200600419A patent/ZA200600419B/en unknown
- 2004-07-29 EP EP04741319A patent/EP1660077B1/en active Active
- 2004-07-29 KR KR1020067001738A patent/KR20060123699A/ko not_active Application Discontinuation
- 2004-07-29 NZ NZ545301A patent/NZ545301A/en unknown
- 2004-07-29 DE DE602004021394T patent/DE602004021394D1/de active Active
- 2004-07-29 US US10/566,101 patent/US7462640B2/en not_active Expired - Fee Related
- 2004-07-29 MX MXPA06001141A patent/MXPA06001141A/es active IP Right Grant
- 2004-07-29 BR BRPI0413112-6A patent/BRPI0413112A/pt not_active IP Right Cessation
- 2004-07-29 AT AT04741319T patent/ATE432701T1/de not_active IP Right Cessation
- 2004-07-29 PT PT04741319T patent/PT1660077E/pt unknown
- 2004-07-29 CN CNB2004800222711A patent/CN100563650C/zh not_active Expired - Fee Related
- 2004-07-29 RU RU2006105777/04A patent/RU2006105777A/ru unknown
- 2004-07-29 AU AU2004262484A patent/AU2004262484A1/en not_active Abandoned
- 2004-08-02 PE PE2004000735A patent/PE20050280A1/es not_active Application Discontinuation
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2005
- 2005-12-29 IL IL172894A patent/IL172894A0/en unknown
-
2006
- 2006-02-10 NO NO20060682A patent/NO20060682L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06001141A (es) | 2006-04-24 |
| AR045155A1 (es) | 2005-10-19 |
| KR20060123699A (ko) | 2006-12-04 |
| CN1832738A (zh) | 2006-09-13 |
| PE20050280A1 (es) | 2005-06-12 |
| AU2004262484A1 (en) | 2005-02-17 |
| JP2007500164A (ja) | 2007-01-11 |
| RU2006105777A (ru) | 2007-09-20 |
| CN100563650C (zh) | 2009-12-02 |
| US20070043041A1 (en) | 2007-02-22 |
| EP1660077B1 (en) | 2009-06-03 |
| ATE432701T1 (de) | 2009-06-15 |
| EP1660077A1 (en) | 2006-05-31 |
| IL172894A0 (en) | 2006-06-11 |
| ES2222832A1 (es) | 2005-02-01 |
| TW200509907A (en) | 2005-03-16 |
| DE602004021394D1 (de) | 2009-07-16 |
| NO20060682L (no) | 2006-02-10 |
| ES2222832B1 (es) | 2006-02-16 |
| WO2005013976A1 (en) | 2005-02-17 |
| CA2533970A1 (en) | 2005-02-17 |
| BRPI0413112A (pt) | 2006-10-03 |
| NZ545301A (en) | 2008-05-30 |
| US7462640B2 (en) | 2008-12-09 |
| ES2327845T3 (es) | 2009-11-04 |
| PT1660077E (pt) | 2009-09-03 |
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