ZA200510460B - Look-through mutagenesis - Google Patents
Look-through mutagenesisInfo
- Publication number
- ZA200510460B ZA200510460B ZA200510460A ZA200510460A ZA200510460B ZA 200510460 B ZA200510460 B ZA 200510460B ZA 200510460 A ZA200510460 A ZA 200510460A ZA 200510460 A ZA200510460 A ZA 200510460A ZA 200510460 B ZA200510460 B ZA 200510460B
- Authority
- ZA
- South Africa
- Prior art keywords
- mutagenesis
- look
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48328203P | 2003-06-27 | 2003-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200510460B true ZA200510460B (en) | 2006-11-29 |
Family
ID=33563915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200510460A ZA200510460B (en) | 2003-06-27 | 2005-12-22 | Look-through mutagenesis |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050136428A1 (xx) |
EP (1) | EP1660655B1 (xx) |
JP (2) | JP4791960B2 (xx) |
KR (1) | KR20060034650A (xx) |
CN (1) | CN1836041A (xx) |
AU (1) | AU2004254352A1 (xx) |
BR (1) | BRPI0412007A (xx) |
CA (1) | CA2542192C (xx) |
ES (1) | ES2609102T3 (xx) |
IL (1) | IL172736A0 (xx) |
NO (1) | NO20060108L (xx) |
RU (1) | RU2005140664A (xx) |
WO (1) | WO2005003345A2 (xx) |
ZA (1) | ZA200510460B (xx) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7329725B1 (en) * | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
MX2007000105A (es) * | 2004-07-06 | 2007-07-18 | Bioren Inc | Mutagenesis look-through para crear polipeptidos alterados con propiedades mejoradas. |
EP1769003A1 (en) * | 2004-07-06 | 2007-04-04 | Bioren, Inc. | HIGH AFFINITY ANTI-TNF-alpha ANTIBODIES AND METHOD |
WO2006014498A2 (en) | 2004-07-06 | 2006-02-09 | Bioren, Inc. | Universal antibody libraries |
US20080207467A1 (en) * | 2005-03-03 | 2008-08-28 | Xencor, Inc. | Methods for the design of libraries of protein variants |
WO2006094234A1 (en) * | 2005-03-03 | 2006-09-08 | Xencor, Inc. | Methods for the design of libraries of protein variants |
JP5315489B2 (ja) * | 2005-04-26 | 2013-10-16 | アール クレア アンド カンパニー | エフェクター機能が増強されたヒトIgG抗体を作製する方法 |
KR20080068004A (ko) * | 2005-08-15 | 2008-07-22 | 아라나 테라퓨틱스 리미티드 | 뉴 월드 영장류 구조형성영역을 가진 조작 항체 |
WO2007054816A2 (en) * | 2005-11-14 | 2007-05-18 | Bioren, Inc. | Antibody ultrahumanization by predicted mature cdr blasting and cohort library generation and screening |
WO2007086994A1 (en) * | 2005-11-15 | 2007-08-02 | Balyasnikova Irina V | Single chain fragment of monoclonal antibody 9b9 and uses thereof |
EP1969010A4 (en) | 2005-12-20 | 2009-07-22 | Peptech Ltd | ANTIBODY TO ANOTHER ANTI-INFLAMMATORY DOMAIN |
EA017417B1 (ru) | 2006-02-01 | 2012-12-28 | Сефалон Астралия Пти Лтд. | КОНСТРУКТ ОДНОДОМЕННОГО АНТИТЕЛА, КОТОРЫЙ СВЯЗЫВАЕТСЯ С ЧЕЛОВЕЧЕСКИМ TNF-α, И ЕГО ПРИМЕНЕНИЕ |
US7704953B2 (en) * | 2006-02-17 | 2010-04-27 | Mdrna, Inc. | Phage displayed cell binding peptides |
US20070224627A1 (en) * | 2006-03-23 | 2007-09-27 | Lawrence Horowitz | Facilitation of translocation of molecules through the gastrointestinal tract |
CA2652452C (en) | 2006-05-15 | 2018-07-31 | Sea Lane Biotechnologies, Llc | Neutralizing antibodies to influenza viruses |
WO2007136840A2 (en) * | 2006-05-20 | 2007-11-29 | Codon Devices, Inc. | Nucleic acid library design and assembly |
WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
WO2008042754A2 (en) * | 2006-10-02 | 2008-04-10 | Sea Lane Biotechnologies, Llc | Design and construction of diverse synthetic peptide and polypeptide libraries |
EP2078077A2 (en) * | 2006-10-04 | 2009-07-15 | Codon Devices, Inc | Nucleic acid libraries and their design and assembly |
BRPI0812206A2 (pt) * | 2007-06-06 | 2014-10-14 | Danisco Us Inc Genencor Div | Métodos para melhorar o desempenho de proteínas |
WO2009009045A2 (en) * | 2007-07-10 | 2009-01-15 | The Scripps Research Institute | Escape libraries of target polypeptides |
WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
WO2009068630A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs |
AU2009228058A1 (en) | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
EP2131243B1 (en) * | 2008-06-02 | 2015-07-01 | ASML Netherlands B.V. | Lithographic apparatus and method for calibrating a stage position |
AU2010233658B2 (en) | 2009-04-10 | 2013-11-28 | Ablynx Nv | Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders |
WO2010115995A2 (en) | 2009-04-10 | 2010-10-14 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
SG176095A1 (en) | 2009-06-05 | 2011-12-29 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
EP3042957B1 (en) | 2009-07-17 | 2017-09-13 | Bioatla LLC | Simultaneous, integrated selection and evolution of human protein performance and expression in production hosts |
GB0914691D0 (en) * | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
WO2011051333A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Universal fibronectin type iii bottom-side binding domain libraries |
WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2012016245A2 (en) | 2010-07-30 | 2012-02-02 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
US9753040B2 (en) | 2010-12-01 | 2017-09-05 | Mitsubishi Tanabe Pharma Corporation | Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same |
AU2012311443B2 (en) | 2011-09-23 | 2016-12-01 | Ablynx Nv | Prolonged inhibition of interleukin-6 mediated signaling |
CA2863468A1 (en) | 2012-03-02 | 2013-09-06 | Ablynx Nv | Pseudomonas aeruginosa pcrv binding single variable domain antibodies |
USRE49477E1 (en) | 2012-04-20 | 2023-03-28 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
DK2855674T4 (da) * | 2012-05-25 | 2022-11-21 | Chr Hansen As | Chymosinvarianter med forbedrede mælkekoagulerende egenskaber |
WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
WO2014092458A1 (ko) * | 2012-12-11 | 2014-06-19 | 연세대학교 산학협력단 | 코돈 조합화 및 변이유발을 이용한 유전자 라이브러리의 합성 방법 |
US20140314741A1 (en) * | 2013-04-18 | 2014-10-23 | Developmen Center For Biotechnology | Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases |
CA2924520C (en) * | 2013-11-01 | 2023-09-26 | Ibc Pharmaceuticals, Inc. | Bispecific antibodies that neutralize both tnf-alpha and il-6: novel therapeutic agent for autoimmune disease |
CN104805507B (zh) * | 2014-01-29 | 2019-01-22 | 杭州康万达医药科技有限公司 | 噬菌体展示文库及其应用和制备方法 |
UA121380C2 (uk) | 2014-02-26 | 2020-05-25 | Кр. Гансен А/С | Поліпептид хімозину з удосконаленими властивостями щодо згортання молока |
AU2015334984A1 (en) | 2014-10-21 | 2017-04-13 | Ablynx Nv | Treatment of IL-6R related diseases |
AU2016282825B2 (en) | 2015-06-22 | 2022-11-17 | Chr. Hansen A/S | Variants of chymosin with improved properties |
AU2016315269B2 (en) | 2015-08-31 | 2021-09-23 | Chr. Hansen A/S | Variants of chymosin with improved properties |
SG11201805556QA (en) * | 2016-01-08 | 2018-07-30 | Momotaro Gene Inc | A combination therapy using REIC/Dkk-3 gene and a checkpoint inhibitor |
CN109688825A (zh) | 2016-05-19 | 2019-04-26 | 科·汉森有限公司 | 具有改善的凝乳特性的凝乳酶的变体 |
US10961524B2 (en) | 2016-05-19 | 2021-03-30 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
AU2017321894A1 (en) | 2016-09-02 | 2019-03-14 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with duoCARs |
US11891426B2 (en) | 2017-12-15 | 2024-02-06 | Aleta Biotherapeutics Inc. | CD19 variants |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2079802C (en) * | 1990-04-05 | 2001-09-18 | Roberto Crea | Walk-through mutagenesis |
WO1995023813A1 (en) * | 1994-03-04 | 1995-09-08 | Merck & Co., Inc. | In vitro antibody affinity maturation using alanine scanning mutagenesis |
AU784983B2 (en) * | 1999-12-15 | 2006-08-17 | Genentech Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
-
2004
- 2004-06-25 ES ES04756045.3T patent/ES2609102T3/es not_active Expired - Lifetime
- 2004-06-25 AU AU2004254352A patent/AU2004254352A1/en not_active Abandoned
- 2004-06-25 WO PCT/US2004/020306 patent/WO2005003345A2/en active Search and Examination
- 2004-06-25 BR BRPI0412007-8A patent/BRPI0412007A/pt not_active IP Right Cessation
- 2004-06-25 KR KR1020057025136A patent/KR20060034650A/ko not_active Application Discontinuation
- 2004-06-25 EP EP04756045.3A patent/EP1660655B1/en not_active Expired - Lifetime
- 2004-06-25 CA CA2542192A patent/CA2542192C/en not_active Expired - Lifetime
- 2004-06-25 CN CNA2004800229706A patent/CN1836041A/zh active Pending
- 2004-06-25 RU RU2005140664/13A patent/RU2005140664A/ru not_active Application Discontinuation
- 2004-06-25 US US10/877,467 patent/US20050136428A1/en not_active Abandoned
- 2004-06-25 JP JP2006517625A patent/JP4791960B2/ja not_active Expired - Lifetime
-
2005
- 2005-12-21 IL IL172736A patent/IL172736A0/en unknown
- 2005-12-22 ZA ZA200510460A patent/ZA200510460B/xx unknown
-
2006
- 2006-01-06 NO NO20060108A patent/NO20060108L/no not_active Application Discontinuation
-
2011
- 2011-03-22 JP JP2011062697A patent/JP5358604B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BRPI0412007A (pt) | 2006-08-15 |
WO2005003345A3 (en) | 2005-03-24 |
CA2542192C (en) | 2013-05-28 |
JP2011182794A (ja) | 2011-09-22 |
JP4791960B2 (ja) | 2011-10-12 |
RU2005140664A (ru) | 2007-08-27 |
EP1660655A2 (en) | 2006-05-31 |
EP1660655B1 (en) | 2016-11-02 |
CA2542192A1 (en) | 2005-01-13 |
NO20060108L (no) | 2006-03-24 |
US20050136428A1 (en) | 2005-06-23 |
JP5358604B2 (ja) | 2013-12-04 |
KR20060034650A (ko) | 2006-04-24 |
IL172736A0 (en) | 2006-04-10 |
AU2004254352A1 (en) | 2005-01-13 |
WO2005003345A2 (en) | 2005-01-13 |
ES2609102T3 (es) | 2017-04-18 |
CN1836041A (zh) | 2006-09-20 |
JP2007524390A (ja) | 2007-08-30 |
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