ZA200508990B - Chemical compounds - Google Patents
Chemical compounds Download PDFInfo
- Publication number
- ZA200508990B ZA200508990B ZA200508990A ZA200508990A ZA200508990B ZA 200508990 B ZA200508990 B ZA 200508990B ZA 200508990 A ZA200508990 A ZA 200508990A ZA 200508990 A ZA200508990 A ZA 200508990A ZA 200508990 B ZA200508990 B ZA 200508990B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- nhc
- phenyl
- compound
- nhs
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 68
- 125000000217 alkyl group Chemical group 0.000 claims description 230
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 68
- -1 NHS(O) Chemical group 0.000 claims description 41
- 125000001072 heteroaryl group Chemical group 0.000 claims description 33
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 125000005843 halogen group Chemical group 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 19
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- 238000000034 method Methods 0.000 claims description 19
- 239000012453 solvate Substances 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 17
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 15
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- 238000011282 treatment Methods 0.000 claims description 15
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 11
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 10
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims description 9
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301369A SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Chemical compounds |
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| ZA200508990B true ZA200508990B (en) | 2007-03-28 |
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|---|---|
| US (1) | US7294636B2 (pt) |
| EP (1) | EP1625120A1 (pt) |
| JP (1) | JP2006525999A (pt) |
| KR (1) | KR20060009318A (pt) |
| CN (1) | CN1784393A (pt) |
| AU (1) | AU2004236147A1 (pt) |
| BR (1) | BRPI0410195A (pt) |
| CA (1) | CA2521580A1 (pt) |
| MX (1) | MXPA05011788A (pt) |
| RU (1) | RU2005131735A (pt) |
| SE (1) | SE0301369D0 (pt) |
| WO (1) | WO2004099178A1 (pt) |
| ZA (1) | ZA200508990B (pt) |
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| US7482337B2 (en) * | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE102004009039A1 (de) * | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
| DE102004030502A1 (de) * | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
| WO2006034279A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| ES2277745B1 (es) * | 2005-06-14 | 2008-06-01 | Laboratorios Almirall S.A. | Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1. |
| US8121790B2 (en) * | 2007-11-27 | 2012-02-21 | Schlumberger Technology Corporation | Combining reservoir modeling with downhole sensors and inductive coupling |
| EP2568812B1 (en) * | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| CN102766141B (zh) * | 2012-07-31 | 2014-09-03 | 温州医学院 | 8-苄基-3-(3-异丙基-5-甲基-4h-1,2,4-三唑-4-基)-8-氮杂二环[3.2.1]辛烷的制备方法 |
| US20150368648A1 (en) | 2014-06-20 | 2015-12-24 | Yale University | Compositions and methods of inhibiting gene expression in a lung |
| CN104860946A (zh) * | 2015-05-14 | 2015-08-26 | 湖北生物医药产业技术研究院有限公司 | Ccr5拮抗剂的制备方法 |
| US10556899B2 (en) * | 2018-02-09 | 2020-02-11 | Sci Pharmtech, Inc. | Method for preparing Maraviroc |
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| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| GB0108046D0 (en) | 2001-03-30 | 2001-05-23 | Astrazeneca Ab | Chemical compounds |
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| SE0200919D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Chemical compounds |
| SE0203828D0 (sv) | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | Chemical compounds |
| AR042628A1 (es) | 2002-12-20 | 2005-06-29 | Astrazeneca Ab | Derivados de piperidina como moduladores del receptor ccr5 |
| SE0203820D0 (sv) | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | chemical compounds |
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2003
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- 2004-05-06 MX MXPA05011788A patent/MXPA05011788A/es not_active Application Discontinuation
- 2004-05-06 WO PCT/SE2004/000697 patent/WO2004099178A1/en active Application Filing
- 2004-05-06 BR BRPI0410195-2A patent/BRPI0410195A/pt not_active Application Discontinuation
- 2004-05-06 RU RU2005131735/04A patent/RU2005131735A/ru not_active Application Discontinuation
- 2004-05-06 US US10/556,023 patent/US7294636B2/en not_active Expired - Fee Related
- 2004-05-06 KR KR1020057021221A patent/KR20060009318A/ko not_active Application Discontinuation
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- 2004-05-06 CN CNA2004800126324A patent/CN1784393A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0410195A (pt) | 2006-05-23 |
| WO2004099178A1 (en) | 2004-11-18 |
| EP1625120A1 (en) | 2006-02-15 |
| US7294636B2 (en) | 2007-11-13 |
| KR20060009318A (ko) | 2006-01-31 |
| SE0301369D0 (sv) | 2003-05-09 |
| JP2006525999A (ja) | 2006-11-16 |
| AU2004236147A1 (en) | 2004-11-18 |
| RU2005131735A (ru) | 2006-06-10 |
| US20070015788A1 (en) | 2007-01-18 |
| MXPA05011788A (es) | 2006-01-26 |
| CN1784393A (zh) | 2006-06-07 |
| CA2521580A1 (en) | 2004-11-18 |
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