ZA200508180B - 7-([1,4]Dioxan-2-yl)-benzothiazole derivatives as adenosine receptor ligands - Google Patents
7-([1,4]Dioxan-2-yl)-benzothiazole derivatives as adenosine receptor ligands Download PDFInfo
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- ZA200508180B ZA200508180B ZA200508180A ZA200508180A ZA200508180B ZA 200508180 B ZA200508180 B ZA 200508180B ZA 200508180 A ZA200508180 A ZA 200508180A ZA 200508180 A ZA200508180 A ZA 200508180A ZA 200508180 B ZA200508180 B ZA 200508180B
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- South Africa
- Prior art keywords
- methoxy
- dioxan
- benzothiazol
- formula
- compounds
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- 102000009346 Adenosine receptors Human genes 0.000 title claims description 14
- 108050000203 Adenosine receptors Proteins 0.000 title claims description 14
- 239000003446 ligand Substances 0.000 title description 7
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
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- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
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- XBXHCBLBYQEYTI-UHFFFAOYSA-N piperidin-4-ylmethanol Chemical compound OCC1CCNCC1 XBXHCBLBYQEYTI-UHFFFAOYSA-N 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03008038 | 2003-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508180B true ZA200508180B (en) | 2007-03-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508180A ZA200508180B (en) | 2003-04-14 | 2005-10-10 | 7-([1,4]Dioxan-2-yl)-benzothiazole derivatives as adenosine receptor ligands |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6872833B2 (ko) |
| EP (1) | EP1615919B1 (ko) |
| JP (1) | JP4426569B2 (ko) |
| KR (1) | KR100700422B1 (ko) |
| CN (1) | CN100447140C (ko) |
| AR (1) | AR043845A1 (ko) |
| AT (1) | ATE370947T1 (ko) |
| AU (1) | AU2004228193B2 (ko) |
| BR (1) | BRPI0409402A (ko) |
| CA (1) | CA2520852C (ko) |
| CL (1) | CL2004000761A1 (ko) |
| CO (1) | CO5640107A2 (ko) |
| DE (1) | DE602004008447T2 (ko) |
| ES (1) | ES2291868T3 (ko) |
| MX (1) | MXPA05011102A (ko) |
| NO (1) | NO20054794L (ko) |
| RU (1) | RU2005135154A (ko) |
| TW (1) | TW200427685A (ko) |
| WO (1) | WO2004089949A1 (ko) |
| ZA (1) | ZA200508180B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622486B2 (en) * | 2004-09-23 | 2009-11-24 | Reddy Us Therapeutics, Inc. | Pyridine compounds, process for their preparation and compositions containing them |
| US7756037B2 (en) * | 2006-08-14 | 2010-07-13 | Cisco Technology, Inc. | Oversubscription of guaranteed bandwidth |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| EP2970281A4 (en) * | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BENZENE COMPOUNDS |
| US9243001B2 (en) | 2013-03-15 | 2016-01-26 | Epizyme, Inc. | Substituted benzene compounds |
| IL272284B2 (en) * | 2017-08-01 | 2024-01-01 | Merck Patent Gmbh | History of thiazolopyridines, their preparation and pharmaceutical preparations containing them |
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| CZ2003182A3 (cs) * | 2000-06-21 | 2003-06-18 | F. Hoffmann-La Roche Ag | Deriváty benzothiazolu |
| CA2442476A1 (en) * | 2001-03-30 | 2002-10-10 | Pfizer Products Inc. | Pyridazinone aldose reductase inhibitors |
| US6620811B2 (en) | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
| US6734179B2 (en) | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
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2004
- 2004-03-30 US US10/812,736 patent/US6872833B2/en not_active Expired - Fee Related
- 2004-04-07 DE DE602004008447T patent/DE602004008447T2/de not_active Expired - Lifetime
- 2004-04-07 AT AT04726119T patent/ATE370947T1/de active
- 2004-04-07 WO PCT/EP2004/003734 patent/WO2004089949A1/en active IP Right Grant
- 2004-04-07 ES ES04726119T patent/ES2291868T3/es not_active Expired - Lifetime
- 2004-04-07 EP EP04726119A patent/EP1615919B1/en not_active Expired - Lifetime
- 2004-04-07 TW TW093109634A patent/TW200427685A/zh unknown
- 2004-04-07 CA CA2520852A patent/CA2520852C/en not_active Expired - Fee Related
- 2004-04-07 JP JP2006505050A patent/JP4426569B2/ja not_active Expired - Fee Related
- 2004-04-07 RU RU2005135154/04A patent/RU2005135154A/ru not_active Application Discontinuation
- 2004-04-07 AU AU2004228193A patent/AU2004228193B2/en not_active Ceased
- 2004-04-07 CN CNB2004800098019A patent/CN100447140C/zh not_active Expired - Fee Related
- 2004-04-07 MX MXPA05011102A patent/MXPA05011102A/es active IP Right Grant
- 2004-04-07 KR KR1020057019469A patent/KR100700422B1/ko not_active IP Right Cessation
- 2004-04-07 BR BRPI0409402-6A patent/BRPI0409402A/pt not_active IP Right Cessation
- 2004-04-08 CL CL200400761A patent/CL2004000761A1/es unknown
- 2004-04-12 AR ARP040101209A patent/AR043845A1/es not_active Application Discontinuation
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2005
- 2005-10-10 ZA ZA200508180A patent/ZA200508180B/en unknown
- 2005-10-11 CO CO05103899A patent/CO5640107A2/es not_active Application Discontinuation
- 2005-10-18 NO NO20054794A patent/NO20054794L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100700422B1 (ko) | 2007-03-28 |
| NO20054794L (no) | 2005-10-27 |
| CO5640107A2 (es) | 2006-05-31 |
| DE602004008447T2 (de) | 2008-05-21 |
| TW200427685A (en) | 2004-12-16 |
| KR20050111795A (ko) | 2005-11-28 |
| AR043845A1 (es) | 2005-08-17 |
| WO2004089949A1 (en) | 2004-10-21 |
| CA2520852A1 (en) | 2004-10-21 |
| CL2004000761A1 (es) | 2005-02-04 |
| CN1774437A (zh) | 2006-05-17 |
| US6872833B2 (en) | 2005-03-29 |
| EP1615919A1 (en) | 2006-01-18 |
| US20040204584A1 (en) | 2004-10-14 |
| ES2291868T3 (es) | 2008-03-01 |
| AU2004228193B2 (en) | 2009-07-23 |
| ATE370947T1 (de) | 2007-09-15 |
| RU2005135154A (ru) | 2006-06-27 |
| AU2004228193A1 (en) | 2004-10-21 |
| CN100447140C (zh) | 2008-12-31 |
| BRPI0409402A (pt) | 2006-04-25 |
| MXPA05011102A (es) | 2005-12-12 |
| DE602004008447D1 (de) | 2007-10-04 |
| CA2520852C (en) | 2011-10-11 |
| JP2006522765A (ja) | 2006-10-05 |
| EP1615919B1 (en) | 2007-08-22 |
| JP4426569B2 (ja) | 2010-03-03 |
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