ZA200507704B - Compounds for the treatment of metabolic disorders - Google Patents

Compounds for the treatment of metabolic disorders Download PDF

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Publication number
ZA200507704B
ZA200507704B ZA200507704A ZA200507704A ZA200507704B ZA 200507704 B ZA200507704 B ZA 200507704B ZA 200507704 A ZA200507704 A ZA 200507704A ZA 200507704 A ZA200507704 A ZA 200507704A ZA 200507704 B ZA200507704 B ZA 200507704B
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ZA
South Africa
Prior art keywords
carbon atoms
formula
compound
alkyl
hydrogen
Prior art date
Application number
ZA200507704A
Other languages
English (en)
Inventor
Kirvin L Hodge
Sharma Shalini
Borstel Reid W Von
Stephen D Wolpe
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of ZA200507704B publication Critical patent/ZA200507704B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200507704A 2003-04-15 2005-09-23 Compounds for the treatment of metabolic disorders ZA200507704B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46296003P 2003-04-15 2003-04-15

Publications (1)

Publication Number Publication Date
ZA200507704B true ZA200507704B (en) 2007-02-28

Family

ID=33300020

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200507704A ZA200507704B (en) 2003-04-15 2005-09-23 Compounds for the treatment of metabolic disorders

Country Status (25)

Country Link
US (2) US7514555B2 (ja)
EP (1) EP1633340B1 (ja)
JP (2) JP4766693B2 (ja)
KR (1) KR101127390B1 (ja)
CN (2) CN1774244A (ja)
AT (1) ATE487474T1 (ja)
AU (1) AU2004229418B2 (ja)
BR (1) BRPI0409469B1 (ja)
CA (1) CA2521621C (ja)
CY (1) CY1111310T1 (ja)
DE (1) DE602004030004D1 (ja)
DK (1) DK1633340T3 (ja)
ES (1) ES2353601T3 (ja)
HK (1) HK1084026A1 (ja)
IL (1) IL171269A (ja)
MX (1) MXPA05011042A (ja)
NO (1) NO20054791L (ja)
NZ (1) NZ542739A (ja)
PL (1) PL1633340T3 (ja)
PT (1) PT1633340E (ja)
RU (1) RU2358722C2 (ja)
SI (1) SI1633340T1 (ja)
UA (1) UA80195C2 (ja)
WO (1) WO2004091486A2 (ja)
ZA (1) ZA200507704B (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011558A (es) * 2001-06-12 2004-03-26 Wellstat Therapeutics Corp Compuestos para el tratamiento de desordenes metabolicos.
EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
PL377712A1 (pl) * 2003-02-13 2006-02-06 Wellstat Therapeutics Corporation Związki do leczenia zaburzeń metabolicznych
NZ542739A (en) 2003-04-15 2007-02-23 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
WO2004093806A2 (en) 2003-04-22 2004-11-04 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1617835B1 (en) * 2003-04-30 2011-09-28 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DE602004031954D1 (de) * 2003-08-20 2011-05-05 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
EP1868595B1 (en) * 2005-04-01 2012-01-11 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
AU2007208125B2 (en) * 2006-01-25 2012-04-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
WO2007087506A2 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1978948A4 (en) * 2006-02-02 2010-06-16 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER
US8044243B2 (en) * 2006-02-13 2011-10-25 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
NZ570100A (en) * 2006-02-28 2011-01-28 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
CN101410105A (zh) 2006-03-31 2009-04-15 维尔斯达医疗公司 代谢紊乱的组合治疗
MX2008014560A (es) * 2006-05-18 2008-11-28 Wellstat Therapeutics Corp Compuestos para el tratamiento de trastornos metabolicos.
JP5252585B2 (ja) * 2006-06-09 2013-07-31 ウェルスタット セラピューティクス コーポレイション 代謝障害の治療のための化合物
US20100227809A1 (en) * 2006-08-17 2010-09-09 Wellstat Therapeutics Corporation Combination treatment for metabolic disorders
EP2240024A4 (en) * 2008-01-15 2014-05-21 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
DK2268141T3 (da) * 2008-03-13 2019-07-29 Wellstat Therapeutics Corp Forbindelse og fremgangsmåde til at reducere urinsyre
EP2285777B1 (en) * 2008-05-05 2016-09-07 Wellstat Therapeutics Corporation Synthesis of 4-[3-(2,6-dimethylbenzyloxy)phenyl]-4-oxobutanoic acid
EP2365746B1 (en) 2008-11-04 2014-07-16 Wellstat Therapeutics Corporation Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids
JP6458784B2 (ja) * 2016-08-03 2019-01-30 横河電機株式会社 駆動回路および電磁流量計

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MXPA03011558A (es) * 2001-06-12 2004-03-26 Wellstat Therapeutics Corp Compuestos para el tratamiento de desordenes metabolicos.
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EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
PL377712A1 (pl) * 2003-02-13 2006-02-06 Wellstat Therapeutics Corporation Związki do leczenia zaburzeń metabolicznych
NZ542739A (en) 2003-04-15 2007-02-23 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
WO2004093806A2 (en) * 2003-04-22 2004-11-04 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1617835B1 (en) * 2003-04-30 2011-09-28 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DE602004031954D1 (de) * 2003-08-20 2011-05-05 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
US7163470B2 (en) 2004-06-25 2007-01-16 Callaway Golf Company Golf club head
EP1868595B1 (en) 2005-04-01 2012-01-11 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637375A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
WO2007087506A2 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

Also Published As

Publication number Publication date
JP2011178808A (ja) 2011-09-15
ATE487474T1 (de) 2010-11-15
AU2004229418B2 (en) 2008-07-31
JP4766693B2 (ja) 2011-09-07
ES2353601T3 (es) 2011-03-03
RU2005135441A (ru) 2006-03-20
CA2521621C (en) 2011-11-01
PL1633340T3 (pl) 2011-04-29
BRPI0409469A (pt) 2006-04-18
CA2521621A1 (en) 2004-10-28
BRPI0409469B1 (pt) 2016-04-26
DE602004030004D1 (de) 2010-12-23
PT1633340E (pt) 2011-02-22
JP2006523696A (ja) 2006-10-19
EP1633340B1 (en) 2010-11-10
UA80195C2 (en) 2007-08-27
IL171269A (en) 2011-09-27
US20090156681A1 (en) 2009-06-18
MXPA05011042A (es) 2005-12-15
AU2004229418A1 (en) 2004-10-28
JP5371062B2 (ja) 2013-12-18
WO2004091486A3 (en) 2005-01-20
NZ542739A (en) 2007-02-23
RU2358722C2 (ru) 2009-06-20
CN1774244A (zh) 2006-05-17
WO2004091486A2 (en) 2004-10-28
NO20054791D0 (no) 2005-10-18
KR101127390B1 (ko) 2012-03-23
US7514555B2 (en) 2009-04-07
DK1633340T3 (da) 2011-02-07
CY1111310T1 (el) 2015-08-05
NO20054791L (no) 2005-12-20
EP1633340A2 (en) 2006-03-15
US20060014784A1 (en) 2006-01-19
CN101912380A (zh) 2010-12-15
HK1084026A1 (en) 2006-07-21
EP1633340A4 (en) 2009-05-27
SI1633340T1 (sl) 2011-02-28
KR20050121262A (ko) 2005-12-26
US7973052B2 (en) 2011-07-05

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