ZA200503654B - Fused heterocyclic compounds - Google Patents

Info

Publication number

ZA200503654B

ZA200503654B ZA200503654A ZA200503654A ZA200503654B ZA 200503654 B ZA200503654 B ZA 200503654B ZA 200503654 A ZA200503654 A ZA 200503654A ZA 200503654 A ZA200503654 A ZA 200503654A ZA 200503654 B ZA200503654 B ZA 200503654B

Authority

ZA

South Africa

Prior art keywords

compound

alkyl

group

mmol

aryl

Prior art date

2002-11-06

Links

• Espacenet
• Global Dossier
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• 150000002391 heterocyclic compounds Chemical class 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims description 172
• 125000000217 alkyl group Chemical group 0.000 claims description 155
• 125000003118 aryl group Chemical group 0.000 claims description 76
• 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 claims description 62
• 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims description 62
• 125000001153 fluoro group Chemical group F* 0.000 claims description 59
• 229910052739 hydrogen Inorganic materials 0.000 claims description 55
• 239000001257 hydrogen Substances 0.000 claims description 50
• 125000005842 heteroatom Chemical group 0.000 claims description 48
• 238000000034 method Methods 0.000 claims description 46
• 229910052757 nitrogen Inorganic materials 0.000 claims description 46
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 36
• 229910052717 sulfur Inorganic materials 0.000 claims description 34
• 229910052736 halogen Inorganic materials 0.000 claims description 33
• 229910052760 oxygen Inorganic materials 0.000 claims description 32
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
• 125000000304 alkynyl group Chemical group 0.000 claims description 27
• 125000003342 alkenyl group Chemical group 0.000 claims description 26
• 150000002367 halogens Chemical class 0.000 claims description 26
• 125000003545 alkoxy group Chemical group 0.000 claims description 23
• 150000003839 salts Chemical class 0.000 claims description 23
• 208000019901 Anxiety disease Diseases 0.000 claims description 21
• 125000002947 alkylene group Chemical group 0.000 claims description 21
• 229910052799 carbon Inorganic materials 0.000 claims description 19
• 125000001072 heteroaryl group Chemical group 0.000 claims description 19
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 18
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• 239000003814 drug Substances 0.000 claims description 14
• 125000005843 halogen group Chemical group 0.000 claims description 14
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• 235000020824 obesity Nutrition 0.000 claims description 13
• 208000019454 Feeding and Eating disease Diseases 0.000 claims description 12
• 125000005529 alkyleneoxy group Chemical group 0.000 claims description 12
• 230000036506 anxiety Effects 0.000 claims description 12
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
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• 235000014632 disordered eating Nutrition 0.000 claims description 11
• 150000002431 hydrogen Chemical class 0.000 claims description 11
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 11
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• 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 16
• 238000010992 reflux Methods 0.000 description 16
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• 238000002360 preparation method Methods 0.000 description 15
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
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