ZA200502374B - Use of posaconazole for the treatment of fungal infections - Google Patents
Use of posaconazole for the treatment of fungal infections Download PDFInfo
- Publication number
- ZA200502374B ZA200502374B ZA200502374A ZA200502374A ZA200502374B ZA 200502374 B ZA200502374 B ZA 200502374B ZA 200502374 A ZA200502374 A ZA 200502374A ZA 200502374 A ZA200502374 A ZA 200502374A ZA 200502374 B ZA200502374 B ZA 200502374B
- Authority
- ZA
- South Africa
- Prior art keywords
- posaconazole
- treatment
- prevention
- substance
- composition
- Prior art date
Links
- 229960001589 posaconazole Drugs 0.000 title claims description 139
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title claims description 139
- 206010017533 Fungal infection Diseases 0.000 title claims description 51
- 208000031888 Mycoses Diseases 0.000 title claims description 51
- 238000011282 treatment Methods 0.000 title claims description 34
- 230000036470 plasma concentration Effects 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 24
- 208000037026 Invasive Fungal Infections Diseases 0.000 claims description 13
- 206010061598 Immunodeficiency Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 229940121375 antifungal agent Drugs 0.000 claims description 4
- 238000012956 testing procedure Methods 0.000 claims description 4
- 230000000843 anti-fungal effect Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims 27
- 239000000126 substance Substances 0.000 claims 18
- 238000010521 absorption reaction Methods 0.000 description 16
- 230000008030 elimination Effects 0.000 description 9
- 238000003379 elimination reaction Methods 0.000 description 9
- 244000053095 fungal pathogen Species 0.000 description 8
- 241000282412 Homo Species 0.000 description 6
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- 238000002565 electrocardiography Methods 0.000 description 3
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 3
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- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
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- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41298502P | 2002-09-23 | 2002-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200502374B true ZA200502374B (en) | 2006-12-27 |
Family
ID=32030948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200502374A ZA200502374B (en) | 2002-09-23 | 2005-03-22 | Use of posaconazole for the treatment of fungal infections |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040058974A1 (es) |
| EP (1) | EP1542681A2 (es) |
| JP (1) | JP2006503839A (es) |
| CN (1) | CN1688306A (es) |
| AU (1) | AU2003282806A1 (es) |
| BR (1) | BR0314763A (es) |
| CA (1) | CA2499897A1 (es) |
| MX (1) | MXPA05003124A (es) |
| NO (1) | NO20051987L (es) |
| WO (1) | WO2004026303A2 (es) |
| ZA (1) | ZA200502374B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7406092B2 (en) * | 2003-07-21 | 2008-07-29 | Qlogic, Corporation | Programmable pseudo virtual lanes for fibre channel systems |
| GB0409077D0 (en) * | 2004-04-23 | 2004-05-26 | Neutec Pharma Plc | Treatment of fungal infections |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| EP1776109B1 (en) | 2004-08-13 | 2008-12-31 | Schering-Plough Ltd. | Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid |
| MX2008015275A (es) * | 2006-05-30 | 2009-02-06 | Elan Pharma Int Ltd | Formulaciones de posaconazol en nanoparticulas. |
| US9943614B2 (en) | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| WO2013013223A1 (en) | 2011-07-20 | 2013-01-24 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
| US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
| US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
| WO2013109236A2 (en) | 2011-12-21 | 2013-07-25 | Colgate-Palmolive Company | Oral care compositions |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| US10039285B2 (en) | 2012-05-02 | 2018-08-07 | Brigham Young University | Ceragenin particulate materials and methods for making same |
| CN102755628B (zh) * | 2012-07-16 | 2013-10-23 | 中国科学院微生物研究所 | 一种抗真菌的药物组合物 |
| BR112015008804A2 (pt) | 2012-10-17 | 2017-07-04 | Univ Brigham Young | tratamento e prevenção de mastite |
| CA2897150C (en) | 2013-01-07 | 2021-07-13 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| AU2014234992B2 (en) | 2013-03-15 | 2018-01-18 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
| US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
| US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
| US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
| US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
| US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
-
2003
- 2003-09-19 JP JP2004538369A patent/JP2006503839A/ja not_active Withdrawn
- 2003-09-19 BR BR0314763-0A patent/BR0314763A/pt not_active Application Discontinuation
- 2003-09-19 EP EP03774484A patent/EP1542681A2/en not_active Withdrawn
- 2003-09-19 AU AU2003282806A patent/AU2003282806A1/en not_active Abandoned
- 2003-09-19 CN CNA038225883A patent/CN1688306A/zh active Pending
- 2003-09-19 WO PCT/US2003/029762 patent/WO2004026303A2/en not_active Application Discontinuation
- 2003-09-19 MX MXPA05003124A patent/MXPA05003124A/es not_active Application Discontinuation
- 2003-09-19 CA CA002499897A patent/CA2499897A1/en not_active Abandoned
- 2003-09-22 US US10/667,856 patent/US20040058974A1/en not_active Abandoned
-
2005
- 2005-03-22 ZA ZA200502374A patent/ZA200502374B/en unknown
- 2005-04-22 NO NO20051987A patent/NO20051987L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006503839A (ja) | 2006-02-02 |
| CA2499897A1 (en) | 2004-04-01 |
| WO2004026303A2 (en) | 2004-04-01 |
| CN1688306A (zh) | 2005-10-26 |
| WO2004026303A3 (en) | 2004-04-29 |
| EP1542681A2 (en) | 2005-06-22 |
| NO20051987L (no) | 2005-04-22 |
| US20040058974A1 (en) | 2004-03-25 |
| MXPA05003124A (es) | 2005-06-22 |
| AU2003282806A1 (en) | 2004-04-08 |
| BR0314763A (pt) | 2005-07-26 |
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