ZA200502183B - Enos mutants useful for gene therapy - Google Patents

Enos mutants useful for gene therapy Download PDF

Info

Publication number
ZA200502183B
ZA200502183B ZA200502183A ZA200502183A ZA200502183B ZA 200502183 B ZA200502183 B ZA 200502183B ZA 200502183 A ZA200502183 A ZA 200502183A ZA 200502183 A ZA200502183 A ZA 200502183A ZA 200502183 B ZA200502183 B ZA 200502183B
Authority
ZA
South Africa
Prior art keywords
enos
polypeptide
amino acid
polypeptide mutant
activity
Prior art date
Application number
ZA200502183A
Other languages
English (en)
Inventor
Eric Blasko
John Parkinson
Katalin Kauser
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA200502183B publication Critical patent/ZA200502183B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075Nitric-oxide synthase (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
ZA200502183A 2002-08-16 2005-03-15 Enos mutants useful for gene therapy ZA200502183B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40363802P 2002-08-16 2002-08-16

Publications (1)

Publication Number Publication Date
ZA200502183B true ZA200502183B (en) 2006-09-27

Family

ID=31888260

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200502183A ZA200502183B (en) 2002-08-16 2005-03-15 Enos mutants useful for gene therapy

Country Status (15)

Country Link
US (1) US20040096881A1 (pt)
EP (1) EP1553973A4 (pt)
JP (1) JP2005535345A (pt)
KR (1) KR20050042788A (pt)
CN (1) CN1691958A (pt)
AU (1) AU2003265461A1 (pt)
BR (1) BR0313511A (pt)
CA (1) CA2494847A1 (pt)
IL (1) IL166511A0 (pt)
MX (1) MXPA05001906A (pt)
NO (1) NO20051347L (pt)
PL (1) PL375219A1 (pt)
RU (1) RU2005107410A (pt)
WO (1) WO2004016764A2 (pt)
ZA (1) ZA200502183B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074448A1 (en) * 2003-03-24 2005-04-07 The Curator Sof The University Of Missouri Method of treatment of endothelial dysfunction and engineered proteins for same
PL1708690T3 (pl) 2003-11-17 2017-01-31 Biomarin Pharmaceutical Inc. Leczenie fenyloketonurii za pomocą BH4
EP1861721B1 (en) 2005-03-10 2017-05-03 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
JP5068748B2 (ja) * 2005-06-22 2012-11-07 ジェン−プロウブ インコーポレイテッド ポリヌクレオチドを定量するための方法およびアルゴリズム
US10550178B2 (en) * 2010-03-18 2020-02-04 Srikanth Vedamoorthy Antibodies for detecting redox modulated proteins
WO2013049531A2 (en) * 2011-09-29 2013-04-04 University Of South Florida Multilayer magnetic micelle compositions and methods for their use
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
US9782494B2 (en) 2012-02-23 2017-10-10 University Of South Florida Methods of using multilayer magnetic micelle compositions
WO2013154771A1 (en) * 2012-04-12 2013-10-17 Georgia Regents University Redox-resistant nitric oxide synthase
US20170212982A1 (en) * 2014-06-25 2017-07-27 Japan Science And Technology Agency Thermostabilized mutant-predicting apparatus for membrane protein, a thermostabilized mutant-predicting method, and computer program product
CN107802826B (zh) * 2017-10-26 2020-02-18 首都医科大学宣武医院 eNOS突变体在促进血管生成中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1178722A4 (en) * 1999-04-16 2003-03-05 Univ Yale MUTATIONS ENOS USEFUL IN GENE THERAPY AND FOR THE SCREENING OF THERAPEUTIC AGENTS
US6620616B1 (en) * 2000-09-13 2003-09-16 The Cleveland Clinic Foundation Nucleic acids encoding nitric oxide synthase variants

Also Published As

Publication number Publication date
AU2003265461A1 (en) 2004-03-03
PL375219A1 (en) 2005-11-28
US20040096881A1 (en) 2004-05-20
WO2004016764A3 (en) 2005-05-19
NO20051347L (no) 2005-04-28
EP1553973A2 (en) 2005-07-20
KR20050042788A (ko) 2005-05-10
CA2494847A1 (en) 2004-02-26
CN1691958A (zh) 2005-11-02
EP1553973A4 (en) 2006-03-01
JP2005535345A (ja) 2005-11-24
WO2004016764A2 (en) 2004-02-26
BR0313511A (pt) 2006-06-13
RU2005107410A (ru) 2006-01-20
IL166511A0 (en) 2006-01-15
MXPA05001906A (es) 2005-04-28

Similar Documents

Publication Publication Date Title
ZA200502183B (en) Enos mutants useful for gene therapy
US6316199B1 (en) Arginase II
KR100737945B1 (ko) 유전자 치료 및 치료 스크리닝에 유용한 eNOS 돌연변이
US20030228317A1 (en) Gene BRCC-1 and diagnostic and therapeutic uses thereof
CA2429376A1 (en) Mitogenic oxygenase regulators
ZA200502181B (en) Gene therapy for critical limb ischemia with wild type or mutant eNOS
US20090246180A1 (en) Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
US20060110769A1 (en) Regulation of novel human prolyl 4-hydroxylases
US20040241797A1 (en) Use of alphacp1, alphacp2, and hur for modulating gene expression and inducing angiogenesis
JP2001186889A (ja) 良性前立腺肥大と関連するポリヌクレオチドおよびポリペプチド
JP2005527188A (ja) 環状ampホスホジエステラーゼ4d7イソ型及びその使用方法
WO2001038387A1 (fr) Nouveau polypeptide, proteine de 37 kda, parent de l'oxydase cytochrome humaine, et polynucleotide codant pour ledit polypeptide
WO2004020587A2 (en) Carboxypeptidase b related polypeptides and methods of use
EP1842856A2 (en) Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
WO2001096572A1 (fr) Nouveau polypeptide, multi-cuivre oxydase 12, et polynucleotide codant ce polypeptide
JP2002085059A (ja) 新規なtsp1ドメイン含有ポリペプチド
JP2002204695A (ja) ヒト前立腺特異的還元酵素
WO2001038543A1 (fr) NOUVEAU POLYPEPTIDE, ACYL-CoA REDUCTASE HUMAINE 55, ET POLYNUCLEOTIDE CODANT POUR CE POLYPEPTIDE
WO2001048196A1 (fr) Nouveau polypeptide, fibrinogene 9, et polynucleotide codant pour ce polypeptide
WO2001055424A1 (fr) Nouveau polypeptide, proteine d'oxydoreduction 4fe-4s 9, et polynucleotide codant pour ce polypeptide
ZA200103707B (en) Promotion or inhibition of angiogenesis and cardio-vascularization.
MXPA96003897A (en) Factor 10 of fibroblas growth
WO2002002618A1 (fr) Nouveau polypeptide, sous-unite 10 de nadh deshydrogenase, et polynucleotide codant ce polypeptide