ZA200500682B - Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith - Google Patents
Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewithInfo
- Publication number
- ZA200500682B ZA200500682B ZA200500682A ZA200500682A ZA200500682B ZA 200500682 B ZA200500682 B ZA 200500682B ZA 200500682 A ZA200500682 A ZA 200500682A ZA 200500682 A ZA200500682 A ZA 200500682A ZA 200500682 B ZA200500682 B ZA 200500682B
- Authority
- ZA
- South Africa
- Prior art keywords
- cells
- hematopoietic stem
- treatment
- methods
- stem cells
- Prior art date
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title abstract 2
- 208000030533 eye disease Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 5
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 abstract 2
- 210000001210 retinal vessel Anatomy 0.000 abstract 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 210000001525 retina Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39852202P | 2002-07-25 | 2002-07-25 | |
| US46705103P | 2003-05-02 | 2003-05-02 | |
| PCT/US2003/024839 WO2004010959A2 (fr) | 2002-07-25 | 2003-07-25 | Cellules souches hematopoietiques et methodes de traitement de maladies oculaires neovasculaires faisant intervenir ces cellules souches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200500682B true ZA200500682B (en) | 2006-07-26 |
Family
ID=31191212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200500682A ZA200500682B (en) | 2002-07-25 | 2005-01-24 | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7153501B2 (fr) |
| EP (1) | EP1542536B1 (fr) |
| JP (2) | JP2005538742A (fr) |
| KR (2) | KR101095287B1 (fr) |
| CN (1) | CN1307300C (fr) |
| AT (1) | ATE536405T1 (fr) |
| AU (1) | AU2003259687B2 (fr) |
| BR (1) | BR0312920A (fr) |
| CA (1) | CA2493122C (fr) |
| DK (1) | DK1542536T3 (fr) |
| ES (1) | ES2376866T3 (fr) |
| MX (1) | MXPA05000972A (fr) |
| PL (1) | PL216193B1 (fr) |
| PT (1) | PT1542536E (fr) |
| RU (1) | RU2331669C2 (fr) |
| WO (2) | WO2004010959A2 (fr) |
| ZA (1) | ZA200500682B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060104963A1 (en) * | 2002-07-25 | 2006-05-18 | The Scripps Research Institute | Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells |
| WO2006031467A2 (fr) * | 2002-07-25 | 2006-03-23 | The Scripps Research Institute | Cellules souches hematopoietiques de lignees negatives isolees et methodes de traitement associees |
| US20060104962A1 (en) * | 2002-07-25 | 2006-05-18 | The Scripps Research Institute | Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| CA2526670C (fr) * | 2003-05-02 | 2011-06-14 | The Scripps Research Institute | Cellules souches hematopoietiques et methodes de traitement de maladies oculaires neovasculaires utilisant ces cellules souches |
| WO2005042731A1 (fr) * | 2003-10-31 | 2005-05-12 | Children's Medical Center Corporation | Procedes de purification de cellules souches hematopoetiques |
| US8282921B2 (en) | 2004-08-02 | 2012-10-09 | Paul Glidden | tRNA synthetase fragments |
| DE602005012962D1 (de) * | 2004-08-13 | 2009-04-09 | Medtronic Inc | Isolation der endothelvorläuferzellen-untermengen und verfahren zu ihrer verwendung |
| EP1802199A4 (fr) * | 2004-09-03 | 2008-08-27 | Scripps Research Inst | Cellules souches hematopoietiques de lignees negatives isolees et methodes de traitement associees |
| DE102004055615A1 (de) * | 2004-11-16 | 2006-05-18 | Universitätsklinikum Hamburg-Eppendorf | In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung |
| EP1869170A4 (fr) * | 2005-02-24 | 2010-03-17 | Scripps Research Inst | Populations isolees de cellules de moelle osseuse de type myeloide et methodes de traitement correspondantes |
| US20080317721A1 (en) * | 2005-02-24 | 2008-12-25 | The Scripps Research Institute | Method for the Treatment of Retinopathy of Prematurity and Related Retinopathic Diseases |
| US20070231306A1 (en) * | 2005-02-24 | 2007-10-04 | The Scripps Research Institute | Isolated myeloid-like cell populations and methods of treatment therewith |
| BRPI0608272A2 (pt) * | 2005-02-24 | 2009-12-08 | Scripps Research Inst | método para promover revascularização fisiológica benéfica de tecido retinal isquêmico e método de triagem para identificar e avaliar a eficácia terapêutica de agentes terapêuticos potenciais para tratar doenças neovasculares retinais |
| JP4734636B2 (ja) * | 2005-11-02 | 2011-07-27 | 国立大学法人 鹿児島大学 | 免疫染色法、及び当該免疫染色法を利用した細胞の評価方法 |
| US8637005B2 (en) | 2005-11-07 | 2014-01-28 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| CA2628712C (fr) | 2005-11-07 | 2014-02-11 | Amorcyte, Inc. | Compositions et procedes de reparation de lesions vasculaires |
| US20110076255A1 (en) | 2005-11-07 | 2011-03-31 | Pecora Andrew L | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| US9034316B2 (en) | 2006-10-24 | 2015-05-19 | Amorcyte, Llc | Infarct area perfusion-improving compositions and methods of vascular injury repair |
| MY154677A (en) | 2006-03-07 | 2015-07-15 | Shroff Geeta | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
| KR100757265B1 (ko) * | 2006-04-27 | 2007-09-10 | (주) 차바이오텍 | 제대혈 유래 줄기 세포를 포함하는 요실금 치료용 조성물 |
| EP2046349B1 (fr) * | 2006-07-12 | 2015-09-09 | Mesoblast, Inc. | Traitement de la néovascularisation excessive |
| CN101583367B (zh) * | 2006-11-07 | 2013-05-01 | 夏尔再生医学公司 | 用于治疗和控制血管生成介导的疾病的材料和方法 |
| US20100098675A1 (en) * | 2008-05-30 | 2010-04-22 | Nikolai Tankovich | Methods for reducing the side effects of ophthalmic laser surgery |
| CN107595889A (zh) * | 2008-09-12 | 2018-01-19 | 克里奥普拉斯低温生物有限公司 | 缺血性组织的细胞疗法 |
| WO2012005763A1 (fr) | 2010-07-06 | 2012-01-12 | The Scripps Research Institute | Utilisation de populations de cellules progénitrices de type myéloïde pour traiter des tumeurs |
| AU2012321102C1 (en) | 2011-10-27 | 2016-11-10 | Pharma Cinq, Llc | Vectors encoding rod-derived cone viability factor |
| EP2838995A4 (fr) * | 2012-04-16 | 2016-01-06 | Univ California | Thérapie oculaire utilisant des microvésicules de cellules souches embryonnaires |
| KR102254082B1 (ko) * | 2012-08-24 | 2021-05-18 | 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 | 망막 색소 상피 세포 시트의 제조 방법 |
| CN113498347B (zh) * | 2019-02-28 | 2024-02-02 | 深圳大学 | 内皮祖细胞(epc)在治疗早衰综合症疾病的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908763B1 (en) * | 1997-08-22 | 2005-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian common lymphoid progenitor cell |
| CA2326386A1 (fr) * | 1998-04-28 | 1999-11-04 | Nycomed Imaging As | Procedes de separation ameliores |
| US6767737B1 (en) * | 1998-08-31 | 2004-07-27 | New York University | Stem cells bearing an FGF receptor on the cell surface |
| US6780627B1 (en) * | 2000-01-31 | 2004-08-24 | Millennium Pharmaceuticals, Inc. | 22438, 23553, 25278, and 26212 novel human sulfatases |
| WO2002009650A2 (fr) * | 2000-07-31 | 2002-02-07 | New York Medical College | Compositions et procedes destines a la reparation et/ou la regeneration d'un myocarde endommage |
| RU2297425C2 (ru) * | 2001-02-23 | 2007-04-20 | Дзе Скриппс Рисерч Инститьют | Полипептиды, происходящие из триптофанил-трнк-синтетазы, и их применение для регуляции развития кровеносных сосудов |
| EP1490107A4 (fr) * | 2002-03-21 | 2005-11-09 | Univ Florida | Modulation de l'angiogenese |
| US20060034767A1 (en) * | 2002-07-05 | 2006-02-16 | Roger Williams Medical Center | Targeting and tracking of cells to specific organs and tissues in vivo |
-
2003
- 2003-07-25 CN CNB038177358A patent/CN1307300C/zh not_active Expired - Fee Related
- 2003-07-25 US US10/628,783 patent/US7153501B2/en not_active Expired - Fee Related
- 2003-07-25 AT AT03772195T patent/ATE536405T1/de active
- 2003-07-25 BR BRPI0312920-9A patent/BR0312920A/pt not_active IP Right Cessation
- 2003-07-25 PT PT03772195T patent/PT1542536E/pt unknown
- 2003-07-25 JP JP2005505648A patent/JP2005538742A/ja active Pending
- 2003-07-25 MX MXPA05000972A patent/MXPA05000972A/es active IP Right Grant
- 2003-07-25 ES ES03772195T patent/ES2376866T3/es not_active Expired - Lifetime
- 2003-07-25 AU AU2003259687A patent/AU2003259687B2/en not_active Ceased
- 2003-07-25 DK DK03772195.8T patent/DK1542536T3/da active
- 2003-07-25 EP EP03772195A patent/EP1542536B1/fr not_active Expired - Lifetime
- 2003-07-25 CA CA2493122A patent/CA2493122C/fr not_active Expired - Fee Related
- 2003-07-25 WO PCT/US2003/024839 patent/WO2004010959A2/fr active Search and Examination
- 2003-07-25 RU RU2005105065/13A patent/RU2331669C2/ru not_active IP Right Cessation
- 2003-07-25 PL PL374868A patent/PL216193B1/pl unknown
- 2003-07-25 KR KR1020057001388A patent/KR101095287B1/ko not_active IP Right Cessation
- 2003-07-25 KR KR1020117020059A patent/KR20110102961A/ko not_active Application Discontinuation
-
2004
- 2004-04-28 WO PCT/US2004/012989 patent/WO2004098499A2/fr active Application Filing
-
2005
- 2005-01-24 ZA ZA200500682A patent/ZA200500682B/xx unknown
-
2006
- 2006-12-20 US US11/643,571 patent/US20070116685A1/en not_active Abandoned
-
2010
- 2010-06-23 JP JP2010142292A patent/JP5385219B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7153501B2 (en) | 2006-12-26 |
| US20040197902A1 (en) | 2004-10-07 |
| JP2010285434A (ja) | 2010-12-24 |
| RU2005105065A (ru) | 2005-09-10 |
| ES2376866T3 (es) | 2012-03-20 |
| WO2004010959A3 (fr) | 2005-04-07 |
| AU2003259687B2 (en) | 2009-10-29 |
| WO2004098499A2 (fr) | 2004-11-18 |
| AU2003259687A1 (en) | 2004-02-16 |
| ATE536405T1 (de) | 2011-12-15 |
| US20070116685A1 (en) | 2007-05-24 |
| EP1542536A4 (fr) | 2007-05-16 |
| MXPA05000972A (es) | 2005-09-12 |
| EP1542536B1 (fr) | 2011-12-07 |
| DK1542536T3 (da) | 2012-01-23 |
| CN1688196A (zh) | 2005-10-26 |
| EP1542536A2 (fr) | 2005-06-22 |
| PT1542536E (pt) | 2012-02-14 |
| JP5385219B2 (ja) | 2014-01-08 |
| CN1307300C (zh) | 2007-03-28 |
| KR20050027132A (ko) | 2005-03-17 |
| PL374868A1 (en) | 2005-11-14 |
| WO2004010959A2 (fr) | 2004-02-05 |
| KR101095287B1 (ko) | 2011-12-16 |
| CA2493122C (fr) | 2012-11-27 |
| KR20110102961A (ko) | 2011-09-19 |
| WO2004098499A3 (fr) | 2005-10-06 |
| JP2005538742A (ja) | 2005-12-22 |
| PL216193B1 (pl) | 2014-03-31 |
| RU2331669C2 (ru) | 2008-08-20 |
| BR0312920A (pt) | 2007-07-10 |
| CA2493122A1 (fr) | 2004-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200500682B (en) | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith | |
| Ogawa | The importance of adipose-derived stem cells and vascularized tissue regeneration in the field of tissue transplantation | |
| Koc et al. | Mesenchymal stem cells: heading into the clinic | |
| Coleman | Structural fat grafting: more than a permanent filler | |
| MOHY et al. | Autologous in vitro expanded mesenchymal stem cell therapy for human old myocardial infarction | |
| Müller et al. | Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM | |
| Xu et al. | Umbilical cord-derived mesenchymal stem cells isolated by a novel explantation technique can differentiate into functional endothelial cells and promote revascularization | |
| MX2019002288A (es) | Suspensión celular para usarse en el tratamiento de la arteriopatía periférica de las extremidades inferiores. | |
| WO1999046366A8 (fr) | Utilisations de cellules souches humaines mesenchymateuses non autologues | |
| AU8476698A (en) | Human mesenchymal stem cells from peripheral blood | |
| Fierz et al. | Patients with oral tumors. Part 1: Prosthetic rehabilitation following tumor resection. | |
| WO2006091895A3 (fr) | Methode de traitement de la retinopathie du premature et troubles retinopathiques associes | |
| ATE300310T1 (de) | Verfahren zur steigerung von hematopoietischen zellen | |
| Carballo et al. | Cell-based approaches for augmentation of tendon repair | |
| MX2023011658A (es) | Linajes hematopoyeticos derivados de celulas madre pluripotentes. | |
| AU2007266565A1 (en) | Methods of selecting stem cells and uses thereof | |
| US20160120909A1 (en) | Compositions And Methods For The Treatment Of Tinnitus | |
| WO2006031467A3 (fr) | Cellules souches hematopoietiques de lignees negatives isolees et methodes de traitement associees | |
| Bajada et al. | Stem cells in regenerative medicine | |
| Yamaguchi et al. | Angiogenic cell therapy for severe ischemic diseases | |
| MXPA05011752A (es) | Celulas madre hematopoyeticas y metodos de tratamiento de enfermedades oculares neovasculares con las mismas. | |
| Hung | Effects of hypoxic culture on bone marrow mesenchymal stem cells: from bench to bedside | |
| WO2001090316A3 (fr) | Compositions et procedes se rapportant a des cellules dendritiques circulantes humaines | |
| Kathiriya et al. | Harvesting mesenchymal stem cells for dental tissue regeneration | |
| Balasubramanian et al. | Stem cell research: Beyond the headlines |