ZA200500622B - Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor - Google Patents
Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding thereforInfo
- Publication number
- ZA200500622B ZA200500622B ZA200500622A ZA200500622A ZA200500622B ZA 200500622 B ZA200500622 B ZA 200500622B ZA 200500622 A ZA200500622 A ZA 200500622A ZA 200500622 A ZA200500622 A ZA 200500622A ZA 200500622 B ZA200500622 B ZA 200500622B
- Authority
- ZA
- South Africa
- Prior art keywords
- motif
- sequence
- leader sequence
- fivsi
- olynucleotides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108010076504 Protein Sorting Signals Proteins 0.000 title 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
- 235000004279 alanine Nutrition 0.000 abstract 3
- 229930182817 methionine Natural products 0.000 abstract 3
- 239000004474 valine Substances 0.000 abstract 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
- 229960000310 isoleucine Drugs 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0217033A GB0217033D0 (en) | 2002-07-23 | 2002-07-23 | Gene and polypeptide sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200500622B true ZA200500622B (en) | 2007-07-25 |
Family
ID=9940938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200500622A ZA200500622B (en) | 2002-07-23 | 2003-07-23 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
| ZA200703235A ZA200703235B (en) | 2002-07-23 | 2007-04-19 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200703235A ZA200703235B (en) | 2002-07-23 | 2007-04-19 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8258102B2 (de) |
| EP (2) | EP1530639B1 (de) |
| JP (1) | JP4597668B2 (de) |
| KR (1) | KR101246040B1 (de) |
| CN (1) | CN1681930B (de) |
| AT (1) | ATE527364T1 (de) |
| AU (1) | AU2003254495B2 (de) |
| CA (1) | CA2493432A1 (de) |
| DK (1) | DK2390333T3 (de) |
| GB (2) | GB0217033D0 (de) |
| HK (1) | HK1071909A1 (de) |
| NZ (1) | NZ537779A (de) |
| WO (1) | WO2004009819A2 (de) |
| ZA (2) | ZA200500622B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
| EP1877079A4 (de) | 2005-04-15 | 2011-08-31 | Human Matrix Sciences Llc | Aus pflanzen stammende elastinbindungsproteinliganden und verfahren zur verwendung davon |
| WO2007039999A1 (ja) * | 2005-09-30 | 2007-04-12 | Densei-Lambda Kabushiki Kaisha | 電池パック |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| WO2017112847A1 (en) | 2015-12-22 | 2017-06-29 | Albumedix A/S | Improved protein expression strains |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CA3064037A1 (en) | 2017-06-20 | 2018-12-27 | Albumedix Ltd | Improved protein expression strains |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| CA3132840A1 (en) | 2019-03-08 | 2020-09-17 | Obsidian Therapeutics, Inc. | Human carbonic anhydrase 2 compositions and methods for tunable regulation |
| AU2020290522A1 (en) | 2019-06-12 | 2022-01-20 | Obsidian Therapeutics, Inc. | CA2 compositions and methods for tunable regulation |
| US20220267398A1 (en) | 2019-06-12 | 2022-08-25 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| FI86437C (fi) | 1978-12-22 | 1992-08-25 | Biogen Inc | Foerfarande foer framstaellning av polypeptider med de antigena egenskaperna hos ett hepatitis b- virusantigen. |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| JPS6041487A (ja) | 1983-04-25 | 1985-03-05 | ジエネンテツク・インコ−ポレイテツド | 酵母発現系でのアルフア因子配列の使用 |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| GB8613388D0 (en) | 1986-06-03 | 1986-07-09 | Delta Biotechnology Ltd | Induction of galactose regulated gene expression in yeast |
| US4723944A (en) | 1986-06-05 | 1988-02-09 | Jensen Ole R | Fluid collection receptacle with improved non-return valve |
| GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| IE63424B1 (en) | 1987-04-09 | 1995-04-19 | Delta Biotechnology Ltd | Yeast vector |
| JPH0754720B2 (ja) | 1987-04-10 | 1995-06-07 | フレキシブルプリント回路板用電気接続端子 | |
| SE459586B (sv) | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| IL88326A (en) | 1987-11-18 | 1993-03-15 | Gist Brocades Nv | Purification of serum albumin |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| DE58909753D1 (de) | 1988-03-08 | 1997-01-23 | Ciba Geigy Ag | Regeneration von fertilen Gramineen-Pflanzen aus der Unterfamilie Pooideae ausgehend von Protoplasten |
| IL89992A0 (en) | 1988-04-25 | 1989-12-15 | Phillips Petroleum Co | Expression of human serum albumin in methylotrophic yeasts |
| EP0387319B1 (de) * | 1988-07-23 | 1996-03-06 | Delta Biotechnology Limited | Sekretorische leader-sequenzen |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5759802A (en) | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
| US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| CA2017176A1 (en) | 1989-05-22 | 1990-11-22 | Yoshitomi Pharmaceutical Industries Ltd. | Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin |
| JPH0669365B2 (ja) | 1989-05-22 | 1994-09-07 | 株式会社ミドリ十字 | アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法 |
| US5580774A (en) | 1989-07-31 | 1996-12-03 | Eli Lilly And Company | Chimeric antibodies directed against a human glycoprotein antigen |
| GB8927480D0 (en) | 1989-12-05 | 1990-02-07 | Delta Biotechnology Ltd | Mutant fungal strain detection and new promoter |
| JPH0877B2 (ja) | 1989-08-25 | 1996-01-10 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| GB8923521D0 (en) | 1989-10-18 | 1989-12-06 | Delta Biotechnology Ltd | Yeast promoter |
| JP3230091B2 (ja) | 1990-06-25 | 2001-11-19 | ウェルファイド株式会社 | ヒト血清アルブミンの着色抑制方法 |
| JPH06500688A (ja) | 1990-06-29 | 1994-01-27 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | 神経線維腫遺伝子 |
| JPH0671432B2 (ja) | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| WO1993018181A1 (en) | 1992-03-13 | 1993-09-16 | Cornell Research Foundation, Inc. | Synthetic gene sequence for a signal peptide |
| US5521287A (en) | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| JPH06107686A (ja) * | 1992-09-29 | 1994-04-19 | Ito Ham Kk | 新規ペプチド又はその塩 |
| GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
| US5639642A (en) | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| GB9505475D0 (en) * | 1995-03-17 | 1995-05-03 | Danisco | Enzyme |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| WO1998016643A1 (en) | 1996-10-11 | 1998-04-23 | Human Genome Sciences, Inc. | Brain-associated inhibitor of tissue-type plasminogen activator |
| JP2001527387A (ja) | 1997-01-24 | 2001-12-25 | ノボ ノルディスク アクティーゼルスカブ | 合成リーダーペプチド配列 |
| US7067250B1 (en) * | 1997-08-21 | 2006-06-27 | The University Of Arkansas For Medical Sciences | Extracellular serine protease |
| EP1068312A2 (de) * | 1998-04-09 | 2001-01-17 | Genset | Humane 5' est's und kodierte proteine |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| WO2001064834A2 (en) * | 2000-02-28 | 2001-09-07 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1346057A2 (de) * | 2000-12-29 | 2003-09-24 | Rhein Biotech Gesellschaft Für Neue Biotechnologische Prozesse Und Produkte Mbh | Verfahren zum herstellen von heterologen proteinen in einem homothallischen pilz der familie sordariaceae |
| EP1409504A2 (de) * | 2001-03-29 | 2004-04-21 | Incyte Genomics, Inc. | Absonderungsmoleküle |
| WO2003066824A2 (en) * | 2002-02-07 | 2003-08-14 | Aventis Behring Gmbh | Albumin-fused kunitz domain peptides |
| US20060241027A1 (en) * | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
-
2002
- 2002-07-23 GB GB0217033A patent/GB0217033D0/en not_active Ceased
-
2003
- 2003-07-23 CA CA 2493432 patent/CA2493432A1/en not_active Abandoned
- 2003-07-23 EP EP03765208A patent/EP1530639B1/de not_active Expired - Lifetime
- 2003-07-23 WO PCT/GB2003/003273 patent/WO2004009819A2/en active Application Filing
- 2003-07-23 DK DK10193560.9T patent/DK2390333T3/en active
- 2003-07-23 US US10/522,074 patent/US8258102B2/en not_active Expired - Fee Related
- 2003-07-23 JP JP2004522368A patent/JP4597668B2/ja not_active Expired - Lifetime
- 2003-07-23 NZ NZ537779A patent/NZ537779A/en not_active IP Right Cessation
- 2003-07-23 CN CN038221470A patent/CN1681930B/zh not_active Expired - Fee Related
- 2003-07-23 AT AT03765208T patent/ATE527364T1/de not_active IP Right Cessation
- 2003-07-23 AU AU2003254495A patent/AU2003254495B2/en not_active Ceased
- 2003-07-23 ZA ZA200500622A patent/ZA200500622B/xx unknown
- 2003-07-23 KR KR1020057001329A patent/KR101246040B1/ko active IP Right Grant
- 2003-07-23 EP EP10193560.9A patent/EP2390333B1/de not_active Expired - Lifetime
- 2003-07-23 GB GB0501988A patent/GB2406571B/en not_active Expired - Lifetime
-
2005
- 2005-06-15 HK HK05105012A patent/HK1071909A1/xx not_active IP Right Cessation
-
2007
- 2007-04-19 ZA ZA200703235A patent/ZA200703235B/en unknown
-
2012
- 2012-08-08 US US13/569,697 patent/US9133265B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004009819A3 (en) | 2004-03-25 |
| JP4597668B2 (ja) | 2010-12-15 |
| CN1681930B (zh) | 2012-09-26 |
| KR101246040B1 (ko) | 2013-03-27 |
| EP2390333A1 (de) | 2011-11-30 |
| GB0217033D0 (en) | 2002-08-28 |
| HK1071909A1 (en) | 2005-08-05 |
| CN1681930A (zh) | 2005-10-12 |
| EP1530639B1 (de) | 2011-10-05 |
| AU2003254495B2 (en) | 2009-03-26 |
| US8258102B2 (en) | 2012-09-04 |
| EP1530639A2 (de) | 2005-05-18 |
| EP2390333B1 (de) | 2015-10-21 |
| ATE527364T1 (de) | 2011-10-15 |
| CA2493432A1 (en) | 2004-01-29 |
| AU2003254495A1 (en) | 2004-02-09 |
| KR20050059046A (ko) | 2005-06-17 |
| GB2406571A (en) | 2005-04-06 |
| WO2004009819A2 (en) | 2004-01-29 |
| ZA200703235B (en) | 2009-08-26 |
| US20130059785A1 (en) | 2013-03-07 |
| JP2006501818A (ja) | 2006-01-19 |
| DK2390333T3 (en) | 2015-12-14 |
| GB0501988D0 (en) | 2005-03-09 |
| GB2406571B (en) | 2007-02-21 |
| US20060183187A1 (en) | 2006-08-17 |
| US9133265B2 (en) | 2015-09-15 |
| NZ537779A (en) | 2008-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1071909A1 (en) | Gene and polypeptide sequences | |
| KR890010199A (ko) | 활성화된 사람의 단백질 c의 직접 발현용 벡터 및 화합물 | |
| IL184112A0 (en) | A method for producing polypeptides or proteins in a disulfide-bridged two-chain form | |
| ATE421977T1 (de) | Reinigung von peptiden unter verwendung von metall-ion-affinitätschromatographie | |
| EP0622458A3 (en) | Adrenomedullin. | |
| US6114148C1 (en) | High level expression of proteins | |
| WO2005027953A3 (en) | Use of proline specific endoproteases to hydrolyse peptides and proteins | |
| WO2007036299A3 (de) | Verfahren zur amidierung von polypeptiden mit c-terminalen basischen aminosäuren unter verwendung spezifischer endoproteasen | |
| EP0542863A4 (en) | Expression of recombinant polypeptides with improved purification | |
| ES2273447T3 (es) | Plantas transgenicas resistentes a insectos y procedimientos para mejorar la actividad frente a insectos. | |
| HK1110888A1 (en) | C-terminal modification of polypeptides | |
| WO2002055717A3 (en) | Enhanced secretion of a polypeptide by a microorganism | |
| HUT40701A (en) | Process for preparing peptide derivatives | |
| AU2001275267A1 (en) | Leader peptides for enhancing secretion of recombinant protein from a host cell | |
| ATE409748T1 (de) | Verfahren zur herstellung sekretorischer kex2- derivate | |
| NZ592340A (en) | A method for making a virus vaccine compising Replikin peptides | |
| AU7873798A (en) | N-terminally extended proteins expressed in yeast | |
| ES2072422T3 (es) | Procedimiento para la produccion de peptidos amidados en alfa en el terminal c. | |
| IL162133A0 (en) | Method of increasing protein expression, proteins and polynucleotides | |
| DE68923625T2 (de) | Enzymatischer Prozess zur Herstellung immunomodulatorischer Pentapeptide und Intermediate zu deren Herstellung. | |
| GR3015629T3 (en) | Strain ral-4, useful for production of small proteins and peptides. | |
| EP0750040A3 (de) | Varianten des Makrophagen-stimulierendes-Proteins und Verfahren zur ihrer Herstellung | |
| WO2002095076A3 (en) | Modified polypeptides having protease-resistance and/or protease-sensitivity | |
| Stein et al. | [5] Amino acid analysis of protein bands on stained polyacrylamide gels | |
| CA2227789A1 (en) | Regulated autocrine growth of mammalian cells |