ZA200500097B - Use of orally-available prostacyclin derivatives for the production of a medicament for the treatment of disease states associated with bone marrow edema - Google Patents
Use of orally-available prostacyclin derivatives for the production of a medicament for the treatment of disease states associated with bone marrow edema Download PDFInfo
- Publication number
- ZA200500097B ZA200500097B ZA200500097A ZA200500097A ZA200500097B ZA 200500097 B ZA200500097 B ZA 200500097B ZA 200500097 A ZA200500097 A ZA 200500097A ZA 200500097 A ZA200500097 A ZA 200500097A ZA 200500097 B ZA200500097 B ZA 200500097B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydroxy
- treatment
- group
- production
- pharmaceutical agent
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 59
- 206010051763 Bone marrow oedema Diseases 0.000 title claims description 23
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 201000010099 disease Diseases 0.000 title claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 12
- 150000003815 prostacyclins Chemical class 0.000 title claims description 12
- 239000003814 drug Substances 0.000 title description 10
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- 201000008482 osteoarthritis Diseases 0.000 claims description 20
- -1 hydroxymethylene group Chemical group 0.000 claims description 14
- 239000008177 pharmaceutical agent Substances 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N Valeric acid Natural products CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 5
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- COTOHBYFKOEMEU-PDWIHATRSA-N (5e)-5-[(3as,4s,5r,6as)-5-hydroxy-4-[(3s)-3-hydroxynon-1-ynyl]-3,3a,4,5,6,6a-hexahydro-1h-pentalen-2-ylidene]pentanoic acid Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](C#C[C@@H](O)CCCCCC)[C@H](O)C[C@@H]21 COTOHBYFKOEMEU-PDWIHATRSA-N 0.000 claims description 4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10225551A DE10225551A1 (de) | 2002-06-06 | 2002-06-06 | Verwendung von oral verfügbaren Prostacyclinderivaten für die Herstellung eines Arzneimittels zur Behandlung von Krankheiten, die mit Knochenmarködemen assoziiert sind |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200500097B true ZA200500097B (en) | 2006-06-28 |
Family
ID=29594336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200500097A ZA200500097B (en) | 2002-06-06 | 2005-01-05 | Use of orally-available prostacyclin derivatives for the production of a medicament for the treatment of disease states associated with bone marrow edema |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1515728A2 (de) |
| JP (1) | JP2005536476A (de) |
| KR (1) | KR20050007591A (de) |
| CN (1) | CN1658882A (de) |
| AU (1) | AU2003236715A1 (de) |
| CA (1) | CA2488861A1 (de) |
| DE (1) | DE10225551A1 (de) |
| WO (1) | WO2003103681A2 (de) |
| ZA (1) | ZA200500097B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1993557E (pt) * | 2006-02-03 | 2016-02-10 | Actelion Pharmaceuticals Ltd | Nova formulação de epoprostenol e método de fabrico da mesma |
| TWI520740B (zh) * | 2011-02-02 | 2016-02-11 | 模範健康科技私人企業有限公司 | 利用多硫酸化多醣之骨髓水腫（水腫）的治療 |
| JP2020531549A (ja) * | 2017-08-31 | 2020-11-05 | シャリテ−ウニベルジテーツメディツィン ベルリン | 易感染性患者における筋骨格系損傷の治癒不良を防ぐための免疫調節 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3608088C2 (de) * | 1986-03-07 | 1995-11-16 | Schering Ag | Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten |
| CA2152403C (en) * | 1992-08-07 | 2005-06-21 | Peter Scholz | Use of prostane derivatives of formulae i and ii for the production of a medicament for the treatment of chronic polyarthritis |
| WO1999013880A1 (fr) * | 1997-09-16 | 1999-03-25 | Toray Industries, Inc. | Inhibiteur de la production de chemokine c-c |
| AU2002212996A1 (en) * | 2000-09-28 | 2002-04-08 | Non-Invasive Monitoring Systems, Inc. | External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention |
-
2002
- 2002-06-06 DE DE10225551A patent/DE10225551A1/de not_active Ceased
-
2003
- 2003-06-05 WO PCT/EP2003/005990 patent/WO2003103681A2/de not_active Application Discontinuation
- 2003-06-05 CA CA002488861A patent/CA2488861A1/en not_active Abandoned
- 2003-06-05 AU AU2003236715A patent/AU2003236715A1/en not_active Abandoned
- 2003-06-05 CN CN038129760A patent/CN1658882A/zh active Pending
- 2003-06-05 EP EP03735573A patent/EP1515728A2/de not_active Withdrawn
- 2003-06-05 JP JP2004510800A patent/JP2005536476A/ja active Pending
- 2003-06-05 KR KR10-2004-7019813A patent/KR20050007591A/ko not_active Application Discontinuation
-
2005
- 2005-01-05 ZA ZA200500097A patent/ZA200500097B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003103681A2 (de) | 2003-12-18 |
| EP1515728A2 (de) | 2005-03-23 |
| AU2003236715A1 (en) | 2003-12-22 |
| CA2488861A1 (en) | 2003-12-18 |
| JP2005536476A (ja) | 2005-12-02 |
| DE10225551A1 (de) | 2003-12-24 |
| WO2003103681A3 (de) | 2004-03-25 |
| KR20050007591A (ko) | 2005-01-19 |
| CN1658882A (zh) | 2005-08-24 |
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