ZA200405785B - Lyophilized preparation containing antibodies to the EGF receptor. - Google Patents
Lyophilized preparation containing antibodies to the EGF receptor. Download PDFInfo
- Publication number
- ZA200405785B ZA200405785B ZA200405785A ZA200405785A ZA200405785B ZA 200405785 B ZA200405785 B ZA 200405785B ZA 200405785 A ZA200405785 A ZA 200405785A ZA 200405785 A ZA200405785 A ZA 200405785A ZA 200405785 B ZA200405785 B ZA 200405785B
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- South Africa
- Prior art keywords
- pharmaceutical preparation
- solution
- preparation according
- lyophilised
- antibody
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10163459A DE10163459A1 (de) | 2001-12-21 | 2001-12-21 | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
Publications (1)
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| ZA200405785B true ZA200405785B (en) | 2005-06-29 |
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| ZA200405785A ZA200405785B (en) | 2001-12-21 | 2004-07-20 | Lyophilized preparation containing antibodies to the EGF receptor. |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20050220786A1 (fr) |
| EP (1) | EP1455824B1 (fr) |
| JP (1) | JP2005513110A (fr) |
| KR (1) | KR100942399B1 (fr) |
| CN (1) | CN100515495C (fr) |
| AR (1) | AR037971A1 (fr) |
| AT (1) | ATE403439T1 (fr) |
| AU (1) | AU2002358533B2 (fr) |
| BR (1) | BR0215266A (fr) |
| CA (1) | CA2470316A1 (fr) |
| CO (1) | CO5590939A2 (fr) |
| DE (2) | DE10163459A1 (fr) |
| EC (1) | ECSP045197A (fr) |
| ES (1) | ES2309220T3 (fr) |
| HK (1) | HK1071306A1 (fr) |
| HU (1) | HUP0402192A2 (fr) |
| IL (1) | IL162588A0 (fr) |
| MX (1) | MXPA04006059A (fr) |
| MY (1) | MY139055A (fr) |
| NZ (1) | NZ534211A (fr) |
| PE (1) | PE20030777A1 (fr) |
| PL (1) | PL205982B1 (fr) |
| RU (1) | RU2339402C2 (fr) |
| TW (1) | TWI318884B (fr) |
| UA (1) | UA83461C2 (fr) |
| WO (1) | WO2003053465A2 (fr) |
| ZA (1) | ZA200405785B (fr) |
Families Citing this family (35)
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| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| EE200100603A (et) * | 1999-05-14 | 2003-02-17 | Imclone Systems Incorporated | Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega |
| WO2002011677A2 (fr) * | 2000-08-09 | 2002-02-14 | Imclone Systems Incorporated | Traitement de maladies hyperproliferatives au moyen d'antagonistes du recepteur de facteur de croissance epidermique |
| US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
| EP1399484B1 (fr) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Ligand a double specificite et son utilisation |
| ATE328906T1 (de) * | 2002-06-28 | 2006-06-15 | Domantis Ltd | Dual-specifische liganden mit erhöhter halbwertszeit |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP1578801A2 (fr) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Anticorps a domaine unique ayant une double specificite pour un ligand et son recepteur |
| EP1622941A2 (fr) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Procede de production d'un anticorps contre le recepteur du facteur de croissance epidermique |
| DE10355251A1 (de) * | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
| DE10355904A1 (de) * | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Feste Formen von anti-EGFR-Antikörpern |
| BRPI0507608A (pt) * | 2004-02-12 | 2007-07-03 | Merck Patent Gmbh | formulações de anticorpos anti-egfr lìquidas altamente concentradas |
| EP1735348B1 (fr) * | 2004-03-19 | 2012-06-20 | Imclone LLC | Humain anticorps dirige contre le recepteur du facteur de croissance epidermique |
| JP2008519757A (ja) * | 2004-11-12 | 2008-06-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 抗ｅｇｆｒ抗体の固形物 |
| EP2377554A1 (fr) * | 2005-07-22 | 2011-10-19 | Amgen, Inc | Lyophilisés de protéine concentrés, procédés et utilisations |
| AU2006321364B2 (en) * | 2005-12-01 | 2011-11-10 | Domantis Limited | Noncompetitive domain antibody formats that bind Interleukin 1 Receptor type 1 |
| CA2634547C (fr) * | 2005-12-20 | 2016-10-11 | Bristol-Myers Squibb Company | Formulations de proteine stables |
| US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
| BRPI0713421A2 (pt) * | 2006-06-14 | 2012-03-13 | Imclone Systems Incorporated | Formulação liofolizada, formulação aquosa adequada para a liofilização, e, métodos para estabilizar am anticorpo e para tratar um mamífero |
| JPWO2008029908A1 (ja) * | 2006-09-07 | 2010-01-21 | 協和発酵キリン株式会社 | 抗体を含有する安定な凍結乾燥医薬製剤 |
| WO2008045373A2 (fr) * | 2006-10-06 | 2008-04-17 | Amgen Inc. | Formulations stables |
| EP2094247B1 (fr) * | 2006-10-20 | 2022-06-29 | Amgen Inc. | Formulations stables de polypeptide |
| JP2010528647A (ja) | 2007-06-06 | 2010-08-26 | ドマンティス リミテッド | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| CN101716343A (zh) * | 2008-10-09 | 2010-06-02 | 哈药集团生物工程有限公司 | 一种单克隆抗体的冻干制剂 |
| JP6320042B2 (ja) | 2011-02-11 | 2018-05-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 前立腺癌治療のための抗アルファ−ｖインテグリン抗体 |
| LT2691112T (lt) * | 2011-03-31 | 2018-07-25 | Merck Sharp & Dohme Corp. | Stabilios antikūnų kompozicijos prieš žmogaus programuojamos mirties receptorių pd-1 ir susiję gydymo būdai |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| SG11201401360XA (en) | 2011-10-25 | 2014-05-29 | Onclave Therapeutics Ltd | Antibody formulations and methods |
| JP2019511531A (ja) * | 2016-04-13 | 2019-04-25 | メディミューン，エルエルシー | 高濃度のタンパク質ベース治療薬を含有する医薬組成物における安定化化合物としてのアミノ酸の使用 |
| BR112019013202A2 (pt) | 2016-12-28 | 2019-12-10 | Japan Chem Res | formulação liofilizada |
| CN112512583B (zh) * | 2018-06-01 | 2023-11-14 | 乐天医药生技股份有限公司 | 酞菁染料偶联物组合物 |
| CN113015747A (zh) | 2018-10-19 | 2021-06-22 | 默克专利股份公司 | 用于治疗结肠直肠癌的阿比妥单抗 |
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|---|---|---|---|---|
| DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
| EP0852951A1 (fr) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Compositions pharmaceutiques stables, lyophilisées d'anticorps monoclonaux ou polyclonaux |
| US6627196B1 (en) * | 1999-08-27 | 2003-09-30 | Genentech, Inc. | Dosages for treatment with anti-ErbB2 antibodies |
-
2001
- 2001-12-21 DE DE10163459A patent/DE10163459A1/de not_active Withdrawn
-
2002
- 2002-11-25 UA UA20040705982A patent/UA83461C2/uk unknown
- 2002-11-25 MX MXPA04006059A patent/MXPA04006059A/es active IP Right Grant
- 2002-11-25 HU HU0402192A patent/HUP0402192A2/hu unknown
- 2002-11-25 CN CNB028256948A patent/CN100515495C/zh not_active Expired - Fee Related
- 2002-11-25 EP EP02792797A patent/EP1455824B1/fr not_active Expired - Lifetime
- 2002-11-25 DE DE50212615T patent/DE50212615D1/de not_active Expired - Lifetime
- 2002-11-25 JP JP2003554222A patent/JP2005513110A/ja active Pending
- 2002-11-25 US US10/499,569 patent/US20050220786A1/en not_active Abandoned
- 2002-11-25 PL PL369848A patent/PL205982B1/pl not_active IP Right Cessation
- 2002-11-25 RU RU2004122632/15A patent/RU2339402C2/ru not_active IP Right Cessation
- 2002-11-25 CA CA002470316A patent/CA2470316A1/fr not_active Abandoned
- 2002-11-25 AT AT02792797T patent/ATE403439T1/de not_active IP Right Cessation
- 2002-11-25 KR KR1020047009904A patent/KR100942399B1/ko not_active IP Right Cessation
- 2002-11-25 IL IL16258802A patent/IL162588A0/xx not_active IP Right Cessation
- 2002-11-25 WO PCT/EP2002/013223 patent/WO2003053465A2/fr active IP Right Grant
- 2002-11-25 BR BR0215266-5A patent/BR0215266A/pt not_active IP Right Cessation
- 2002-11-25 NZ NZ534211A patent/NZ534211A/en not_active IP Right Cessation
- 2002-11-25 ES ES02792797T patent/ES2309220T3/es not_active Expired - Lifetime
- 2002-11-25 AU AU2002358533A patent/AU2002358533B2/en not_active Ceased
- 2002-12-12 PE PE2002001204A patent/PE20030777A1/es not_active Application Discontinuation
- 2002-12-18 MY MYPI20024751A patent/MY139055A/en unknown
- 2002-12-20 TW TW091136821A patent/TWI318884B/zh active
- 2002-12-20 AR ARP020105060A patent/AR037971A1/es unknown
-
2004
- 2004-06-18 CO CO04057564A patent/CO5590939A2/es not_active Application Discontinuation
- 2004-07-20 EC EC2004005197A patent/ECSP045197A/es unknown
- 2004-07-20 ZA ZA200405785A patent/ZA200405785B/en unknown
-
2005
- 2005-05-20 HK HK05104237.0A patent/HK1071306A1/xx not_active IP Right Cessation
-
2008
- 2008-03-19 US US12/051,436 patent/US20080166346A1/en not_active Abandoned
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