IL162588A0 - Lyophilized preparation containing antibodies to the egf receptor - Google Patents

Lyophilized preparation containing antibodies to the egf receptor

Info

Publication number
IL162588A0
IL162588A0 IL16258802A IL16258802A IL162588A0 IL 162588 A0 IL162588 A0 IL 162588A0 IL 16258802 A IL16258802 A IL 16258802A IL 16258802 A IL16258802 A IL 16258802A IL 162588 A0 IL162588 A0 IL 162588A0
Authority
IL
Israel
Prior art keywords
preparation containing
egf receptor
lyophilized preparation
containing antibodies
antibodies
Prior art date
Application number
IL16258802A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of IL162588A0 publication Critical patent/IL162588A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL16258802A 2001-12-21 2002-11-25 Lyophilized preparation containing antibodies to the egf receptor IL162588A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10163459A DE10163459A1 (de) 2001-12-21 2001-12-21 Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor
PCT/EP2002/013223 WO2003053465A2 (de) 2001-12-21 2002-11-25 Lyophilisierte zubereitung enthaltend antikörper gegen den egf-rezeptor

Publications (1)

Publication Number Publication Date
IL162588A0 true IL162588A0 (en) 2005-11-20

Family

ID=7710502

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16258802A IL162588A0 (en) 2001-12-21 2002-11-25 Lyophilized preparation containing antibodies to the egf receptor

Country Status (27)

Country Link
US (2) US20050220786A1 (xx)
EP (1) EP1455824B1 (xx)
JP (1) JP2005513110A (xx)
KR (1) KR100942399B1 (xx)
CN (1) CN100515495C (xx)
AR (1) AR037971A1 (xx)
AT (1) ATE403439T1 (xx)
AU (1) AU2002358533B2 (xx)
BR (1) BR0215266A (xx)
CA (1) CA2470316A1 (xx)
CO (1) CO5590939A2 (xx)
DE (2) DE10163459A1 (xx)
EC (1) ECSP045197A (xx)
ES (1) ES2309220T3 (xx)
HK (1) HK1071306A1 (xx)
HU (1) HUP0402192A2 (xx)
IL (1) IL162588A0 (xx)
MX (1) MXPA04006059A (xx)
MY (1) MY139055A (xx)
NZ (1) NZ534211A (xx)
PE (1) PE20030777A1 (xx)
PL (1) PL205982B1 (xx)
RU (1) RU2339402C2 (xx)
TW (1) TWI318884B (xx)
UA (1) UA83461C2 (xx)
WO (1) WO2003053465A2 (xx)
ZA (1) ZA200405785B (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US20030224001A1 (en) * 1998-03-19 2003-12-04 Goldstein Neil I. Antibody and antibody fragments for inhibiting the growth of tumors
ZA200007412B (en) * 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
EP2042194A3 (en) * 1999-05-14 2009-04-22 Imclone Systems, Inc. Treatment of refractory human tumors with epidermal growth factor receptor antagonists
AU2001295002B2 (en) * 2000-08-09 2007-05-31 Imclone Systems Incorporated Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
US20080008704A1 (en) * 2001-03-16 2008-01-10 Mark Rubin Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
DK1399484T3 (da) * 2001-06-28 2010-11-08 Domantis Ltd Dobbelt-specifik ligand og anvendelse af denne
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
EP2135879A3 (en) * 2002-06-28 2010-06-23 Domantis Limited Ligand
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
CA2511910A1 (en) * 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
EP1622941A2 (en) * 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
DE10355251A1 (de) * 2003-11-26 2005-06-23 Merck Patent Gmbh Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor
DE10355904A1 (de) * 2003-11-29 2005-06-30 Merck Patent Gmbh Feste Formen von anti-EGFR-Antikörpern
CN1953768B (zh) * 2004-02-12 2010-10-13 默克专利有限公司 抗-egfr抗体的高浓缩液体制剂
CN103007279B (zh) * 2004-03-19 2017-01-11 英克隆有限责任公司 人抗表皮生长因子受体抗体
JP2008519757A (ja) * 2004-11-12 2008-06-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 抗egfr抗体の固形物
EP2377554A1 (en) * 2005-07-22 2011-10-19 Amgen, Inc Concentrated protein lyophilates, methods and uses
EP1957536A2 (en) * 2005-12-01 2008-08-20 Domantis Limited Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
US9309316B2 (en) 2005-12-20 2016-04-12 Bristol-Myers Squibb Company Stable subcutaneous protein formulations and uses thereof
ES2436616T5 (es) * 2005-12-20 2022-05-27 Bristol Myers Squibb Co Formulaciones proteicas estables
US20100158925A1 (en) * 2006-06-14 2010-06-24 Meera Agarkhed Lyophilized formulations of anti-egfr antibodies
WO2008029908A1 (fr) * 2006-09-07 2008-03-13 Kyowa Hakko Kirin Co., Ltd. Préparation pharmaceutique lyophilisée stable comprenant un anticorps
WO2008045373A2 (en) * 2006-10-06 2008-04-17 Amgen Inc. Stable antibody formulations
ES2925992T3 (es) * 2006-10-20 2022-10-20 Amgen Inc Formulaciones estables de polipéptidos
WO2008149147A2 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
CN101716343A (zh) * 2008-10-09 2010-06-02 哈药集团生物工程有限公司 一种单克隆抗体的冻干制剂
PL2672994T3 (pl) 2011-02-11 2018-11-30 Merck Patent Gmbh Przeciwciało przeciwko integrynie alfa-v do leczenia raka prostaty
TR201810298T4 (tr) * 2011-03-31 2018-08-27 Merck Sharp & Dohme İnsan programlı ölüm reseptörü PD-1'e karşı antikorların stabil formülasyonları ve ilgili tedaviler.
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
KR102196009B1 (ko) 2011-10-25 2021-01-04 프로테나 바이오사이언시즈 리미티드 항체 제형 및 방법
WO2017180594A1 (en) * 2016-04-13 2017-10-19 Medimmune, Llc Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents
BR112019013202A2 (pt) 2016-12-28 2019-12-10 Japan Chem Res formulação liofilizada
SG11202011538RA (en) * 2018-06-01 2020-12-30 Rakuten Medical Inc Phthalocyanine dye conjugate compositions
CN113015747A (zh) 2018-10-19 2021-06-22 默克专利股份公司 用于治疗结肠直肠癌的阿比妥单抗

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
PL202369B1 (pl) * 1999-08-27 2009-06-30 Genentech Inc Zastosowanie przeciwciała skierowanego przeciw ErbB2, zastosowanie przeciwciała skierowanego przeciw ErbB oraz zestaw zawierający to przeciwciało

Also Published As

Publication number Publication date
PL205982B1 (pl) 2010-06-30
JP2005513110A (ja) 2005-05-12
CN100515495C (zh) 2009-07-22
WO2003053465A3 (de) 2003-12-04
HUP0402192A2 (hu) 2005-01-28
PL369848A1 (en) 2005-05-02
AR037971A1 (es) 2004-12-22
WO2003053465A2 (de) 2003-07-03
AU2002358533A1 (en) 2003-07-09
KR100942399B1 (ko) 2010-02-17
TW200306205A (en) 2003-11-16
PE20030777A1 (es) 2003-09-11
EP1455824B1 (de) 2008-08-06
NZ534211A (en) 2006-01-27
US20080166346A1 (en) 2008-07-10
DE50212615D1 (de) 2008-09-18
BR0215266A (pt) 2004-12-07
ES2309220T3 (es) 2008-12-16
RU2339402C2 (ru) 2008-11-27
HK1071306A1 (en) 2005-07-15
US20050220786A1 (en) 2005-10-06
TWI318884B (en) 2010-01-01
RU2004122632A (ru) 2005-05-20
KR20040074099A (ko) 2004-08-21
MXPA04006059A (es) 2004-09-27
DE10163459A1 (de) 2003-07-03
ATE403439T1 (de) 2008-08-15
CA2470316A1 (en) 2003-07-03
ZA200405785B (en) 2005-06-29
CO5590939A2 (es) 2005-12-30
EP1455824A2 (de) 2004-09-15
ECSP045197A (es) 2004-08-27
AU2002358533B2 (en) 2009-01-15
CN1606455A (zh) 2005-04-13
MY139055A (en) 2009-08-28
UA83461C2 (uk) 2008-07-25

Similar Documents

Publication Publication Date Title
IL162588A0 (en) Lyophilized preparation containing antibodies to the egf receptor
HK1203521A1 (en) Antibodies to nsulin-like growth factor receptor
IL235116A0 (en) Antibodies to opgl (osteoprotegerin ligand)
EP1432444A4 (en) ANTI-BETA ANTIBODIES
HK1074206A1 (en) Anti-trail-r antibodies
PT1361893E (pt) Anticorpos anti-rfce modificados com imunogenicidade reduzida
IL213564A0 (en) Antibodies to vla-1
PL356297A1 (en) Recombinant antibodies to human interkleukin-1 beta
GB9911569D0 (en) Antibodies
HUP0400030A3 (en) Antibodies specific for cd44v6
GB0115385D0 (en) Novel preparation
EP1455822A4 (en) LYOPHILIZED MONOCLONAL ANTIBODY COMPOSITIONS
GB2364057A8 (en) G protein coupled receptor
GB0118009D0 (en) Novel preparation
GB0118696D0 (en) Novel antibodies
IL157966A0 (en) Antibodies specific for cd44v6
GB0119553D0 (en) Antibodies
GB0120494D0 (en) Novel antibody
GB0005071D0 (en) Antibodies
GB0003527D0 (en) Antibodies
GB0020568D0 (en) Novel antibody
GB0119479D0 (en) Antigens
GB0111492D0 (en) Antigens
GB0112448D0 (en) Antigens
GB9918051D0 (en) Antibodies

Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees