ZA200405249B - Substituted benzoxazoles and analogues as estrogenic agents - Google Patents
Substituted benzoxazoles and analogues as estrogenic agents Download PDFInfo
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- ZA200405249B ZA200405249B ZA200405249A ZA200405249A ZA200405249B ZA 200405249 B ZA200405249 B ZA 200405249B ZA 200405249 A ZA200405249 A ZA 200405249A ZA 200405249 A ZA200405249 A ZA 200405249A ZA 200405249 B ZA200405249 B ZA 200405249B
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- hydroxyphenyl
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- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 1
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- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- SANWDQJIWZEKOD-UHFFFAOYSA-N tributyl(furan-2-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CO1 SANWDQJIWZEKOD-UHFFFAOYSA-N 0.000 description 1
- YLGRTLMDMVAFNI-UHFFFAOYSA-N tributyl(prop-2-enyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)CC=C YLGRTLMDMVAFNI-UHFFFAOYSA-N 0.000 description 1
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- 241000701161 unidentified adenovirus Species 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
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- GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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US33666301P | 2001-12-05 | 2001-12-05 |
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JP (2) | JP4689960B2 (uk) |
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CN (2) | CN101423500A (uk) |
AR (1) | AR037745A1 (uk) |
AU (2) | AU2002353014A1 (uk) |
BR (1) | BR0214767A (uk) |
CA (1) | CA2467517C (uk) |
CO (1) | CO5580830A2 (uk) |
EC (1) | ECSP045133A (uk) |
HU (1) | HUP0500010A2 (uk) |
IL (1) | IL162256A0 (uk) |
IN (1) | IN2005KO00272A (uk) |
MX (1) | MXPA04005306A (uk) |
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UA (1) | UA83620C2 (uk) |
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ZA (1) | ZA200405249B (uk) |
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JP4381810B2 (ja) | 2001-11-19 | 2009-12-09 | イーライ リリー アンド カンパニー | 選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン |
UA83620C2 (uk) | 2001-12-05 | 2008-08-11 | Уайт | Заміщені бензоксазоли та їх аналоги як естрогенні агенти |
US20040002524A1 (en) * | 2002-06-24 | 2004-01-01 | Richard Chesworth | Benzimidazole compounds and their use as estrogen agonists/antagonists |
TW200409759A (en) * | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
CA2510455C (en) | 2002-12-19 | 2013-03-12 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
DE602004016150D1 (de) * | 2003-04-21 | 2008-10-09 | Lilly Co Eli | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
TW200500065A (en) * | 2003-05-21 | 2005-01-01 | Wyeth Corp | Antiarthritic combinations |
EP2314584A1 (en) * | 2004-05-20 | 2011-04-27 | Foldrx Pharmaceuticals, Inc. | 2-(heteroaryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
WO2006007503A1 (en) * | 2004-07-01 | 2006-01-19 | Wyeth | Tetracyclic compounds as estrogen ligands |
TW200612925A (en) * | 2004-08-26 | 2006-05-01 | Wyeth Corp | Prodrug substituted benzoxazoles as estrogenic agents |
AR050719A1 (es) * | 2004-09-02 | 2006-11-15 | Wyeth Corp | Carbonilfenoles de fenantridina que actuan como ligandos del receptor de estrogeno |
JP2008512458A (ja) | 2004-09-07 | 2008-04-24 | ワイス | 6H−[1]ベンゾピラノ[4,3−b]キノリン及びエストロゲン様物質としてのそれらの使用 |
AU2005312031A1 (en) * | 2004-12-02 | 2006-06-08 | Wyeth | Formulations of substituted benzoxazoles |
RU2007120253A (ru) * | 2004-12-02 | 2009-01-10 | Вайет (Us) | Составы, содержащие замещенные бензоксазолы |
WO2006060542A2 (en) * | 2004-12-02 | 2006-06-08 | Wyeth | Formulations of substituted benzoxazoles |
CN101321524A (zh) * | 2004-12-17 | 2008-12-10 | 惠氏公司 | 雌激素β激动剂的新用途 |
US8093302B2 (en) * | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
BRPI0608154A2 (pt) * | 2005-02-16 | 2016-10-11 | Wyeth Corp | métodos de tratar ou inibir mucosite, cistite por radiação em um indivíduo, e de tratar pelo menos um sintoma de exposição de um indivíduo a um agente citotóxico ou à radiação, e, composição farmacêutica |
US20060199852A1 (en) * | 2005-03-07 | 2006-09-07 | Wyeth | Process for the preparation of substituted benzoxazole compounds |
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