ZA200405249B - Substituted benzoxazoles and analogues as estrogenic agents - Google Patents

Substituted benzoxazoles and analogues as estrogenic agents Download PDF

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Publication number
ZA200405249B
ZA200405249B ZA200405249A ZA200405249A ZA200405249B ZA 200405249 B ZA200405249 B ZA 200405249B ZA 200405249 A ZA200405249 A ZA 200405249A ZA 200405249 A ZA200405249 A ZA 200405249A ZA 200405249 B ZA200405249 B ZA 200405249B
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South Africa
Prior art keywords
composition
substance
hydroxyphenyl
treating
compound
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ZA200405249A
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English (en)
Inventor
Malamas Michael Sotirios
Gunawan Iwan
Collini Michael David
Keith James Carl Jr
Lyttle Cecil Richard
Mcdevitt Robert Emmett
Manas Eric Steven
Harris Heather Anne
Albert Leo Massillamoney
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Wyeth Corp
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Publication of ZA200405249B publication Critical patent/ZA200405249B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57Aryl or substituted aryl radicals
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
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    • AHUMAN NECESSITIES
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    • A61P9/12Antihypertensives
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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ZA200405249A 2001-12-05 2004-07-01 Substituted benzoxazoles and analogues as estrogenic agents ZA200405249B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33666301P 2001-12-05 2001-12-05

Publications (1)

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ZA200405249B true ZA200405249B (en) 2007-01-31

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ZA200405249A ZA200405249B (en) 2001-12-05 2004-07-01 Substituted benzoxazoles and analogues as estrogenic agents

Country Status (24)

Country Link
US (4) US6794403B2 (uk)
EP (2) EP1451165A1 (uk)
JP (2) JP4689960B2 (uk)
KR (1) KR20050044717A (uk)
CN (2) CN101423500A (uk)
AR (1) AR037745A1 (uk)
AU (2) AU2002353014A1 (uk)
BR (1) BR0214767A (uk)
CA (1) CA2467517C (uk)
CO (1) CO5580830A2 (uk)
EC (1) ECSP045133A (uk)
HU (1) HUP0500010A2 (uk)
IL (1) IL162256A0 (uk)
IN (1) IN2005KO00272A (uk)
MX (1) MXPA04005306A (uk)
NO (1) NO20042811L (uk)
NZ (1) NZ560878A (uk)
PL (1) PL370771A1 (uk)
RU (2) RU2330847C2 (uk)
SG (1) SG165987A1 (uk)
TW (1) TW200304822A (uk)
UA (1) UA83620C2 (uk)
WO (1) WO2003050095A1 (uk)
ZA (1) ZA200405249B (uk)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4381810B2 (ja) 2001-11-19 2009-12-09 イーライ リリー アンド カンパニー 選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン
UA83620C2 (uk) 2001-12-05 2008-08-11 Уайт Заміщені бензоксазоли та їх аналоги як естрогенні агенти
US20040002524A1 (en) * 2002-06-24 2004-01-01 Richard Chesworth Benzimidazole compounds and their use as estrogen agonists/antagonists
TW200409759A (en) * 2002-09-25 2004-06-16 Wyeth Corp Substituted 4-(indazol-3-yl)phenols
CA2510455C (en) 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
DE602004016150D1 (de) * 2003-04-21 2008-10-09 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
TW200500065A (en) * 2003-05-21 2005-01-01 Wyeth Corp Antiarthritic combinations
EP2314584A1 (en) * 2004-05-20 2011-04-27 Foldrx Pharmaceuticals, Inc. 2-(heteroaryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
WO2006007503A1 (en) * 2004-07-01 2006-01-19 Wyeth Tetracyclic compounds as estrogen ligands
TW200612925A (en) * 2004-08-26 2006-05-01 Wyeth Corp Prodrug substituted benzoxazoles as estrogenic agents
AR050719A1 (es) * 2004-09-02 2006-11-15 Wyeth Corp Carbonilfenoles de fenantridina que actuan como ligandos del receptor de estrogeno
JP2008512458A (ja) 2004-09-07 2008-04-24 ワイス 6H−[1]ベンゾピラノ[4,3−b]キノリン及びエストロゲン様物質としてのそれらの使用
AU2005312031A1 (en) * 2004-12-02 2006-06-08 Wyeth Formulations of substituted benzoxazoles
RU2007120253A (ru) * 2004-12-02 2009-01-10 Вайет (Us) Составы, содержащие замещенные бензоксазолы
WO2006060542A2 (en) * 2004-12-02 2006-06-08 Wyeth Formulations of substituted benzoxazoles
CN101321524A (zh) * 2004-12-17 2008-12-10 惠氏公司 雌激素β激动剂的新用途
US8093302B2 (en) * 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
BRPI0608154A2 (pt) * 2005-02-16 2016-10-11 Wyeth Corp métodos de tratar ou inibir mucosite, cistite por radiação em um indivíduo, e de tratar pelo menos um sintoma de exposição de um indivíduo a um agente citotóxico ou à radiação, e, composição farmacêutica
US20060199852A1 (en) * 2005-03-07 2006-09-07 Wyeth Process for the preparation of substituted benzoxazole compounds
US7579478B2 (en) * 2005-03-07 2009-08-25 Wyeth Process for the purification of substituted benzoxazole compounds
US7683182B2 (en) * 2005-03-08 2010-03-23 Wyeth Llc Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
EP2336117A1 (en) 2005-05-26 2011-06-22 Neuron Systems, Inc Heterocyclic compounds for treating retinal diseases
PE20070427A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
WO2007095286A2 (en) * 2006-02-14 2007-08-23 Wyeth AQUEOUS PHARMACEUTICAL FORMULATIONS OF ERβ SELECTIVE LIGANDS
WO2007103869A2 (en) * 2006-03-06 2007-09-13 Wyeth Liquid and semi-solid pharmaceutical formulations and processes
US20070208069A1 (en) * 2006-03-06 2007-09-06 Wyeth Pharmaceutical formulations of an anhydrous crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
AU2007223278A1 (en) * 2006-03-06 2007-09-13 Wyeth Tablet formulations and processes
US20070207202A1 (en) * 2006-03-06 2007-09-06 Wyeth Pharmaceutical formulations of a monohydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
JP4986485B2 (ja) 2006-03-28 2012-07-25 株式会社Adeka エポキシ樹脂硬化性組成物
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
US20080175901A1 (en) * 2006-11-21 2008-07-24 Wyeth Pharmaceutical formulations of a crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20080139633A1 (en) * 2006-11-21 2008-06-12 Wyeth Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20080176914A1 (en) * 2006-11-21 2008-07-24 Wyeth Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20080175900A1 (en) * 2006-11-21 2008-07-24 Wyeth Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
EP2064195A2 (en) * 2006-11-21 2009-06-03 Wyeth Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol and pharmaceutical formulations thereof
US20080241234A1 (en) * 2006-11-21 2008-10-02 Wyeth Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20090239920A1 (en) * 2006-11-21 2009-09-24 Wyeth Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20080132554A1 (en) * 2006-11-21 2008-06-05 Wyeth Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US20080146630A1 (en) * 2006-11-21 2008-06-19 Wyeth Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
MX2009007831A (es) 2007-01-22 2010-01-15 Gtx Inc Agentes de union de receptor nuclear.
US20080182872A1 (en) * 2007-01-31 2008-07-31 Wyeth Use of er-beta selective ligands for treating acute lung injuries
WO2008100769A2 (en) * 2007-02-09 2008-08-21 Wyeth Process for selective sulfation of aromatic hydroxyl groups
US20080262010A1 (en) * 2007-04-20 2008-10-23 Wyeth Crystalline polymorphs of n-(3-(dimethylamino)propyl)-4-(4-(3-fluoro-4-methoxyphenyl) pyrimidin-2-ylamino) benzenesulfonamide as d-glucoronate salts
US20080262008A1 (en) * 2007-04-20 2008-10-23 Wyeth Crystalline forms and polymorphs of n-(3-(dimethylamino)propyl)-4-(4-(3-fluoro-4-methoxyphenyl) pyrimidin-2-ylamino) benzenesulfonamide as succinate salts
US20080275073A1 (en) * 2007-04-20 2008-11-06 Wyeth Crystalline forms and polymorphs of n-(3-(dimethylamino)propyl)-4-(4-(3-fluoro-4-methoxyphenyl) pyrimidin-2-ylamino) benzenesulfonamide as pharmaceutically acceptable salts
US20080262009A1 (en) * 2007-04-20 2008-10-23 Wyeth Crystalline polymorphs of n-(3-(dimethylamino)propyl)-4-(4-(3-fluoro-4-methoxyphenyl) pyrimidin-2-ylamino) benzenesulfonamide as acetate salts
WO2009009417A2 (en) * 2007-07-06 2009-01-15 Wyeth Pharmaceutical compositions and methods of preventing, treating, or inhibiting inflammatory diseases, disorders, or conditions of the skin, and diseases, disorders, or conditions associated with collagen depletion
WO2009100335A1 (en) * 2008-02-08 2009-08-13 Wyeth Phosphate derivatives of substituted benzoxazoles
JP5486602B2 (ja) * 2008-09-26 2014-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンゾオキサゾール化合物および使用方法
WO2010036908A1 (en) * 2008-09-26 2010-04-01 Eisai R & D Management Co., Ltd. Use of benzoxazole compounds in the treatment of malaria
WO2010083199A1 (en) 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
WO2011014516A1 (en) 2009-07-28 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Estrogen antagonists as treatments for sclerosing disorders
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
EP2621492A1 (en) * 2010-10-01 2013-08-07 Indiana University Research and Technology Corporation Treatment of symptoms associated with menopause
WO2012118935A1 (en) * 2011-03-03 2012-09-07 Proteotech Inc Compounds for the treatment of neurodegenerative diseases
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
US9615580B2 (en) * 2012-12-27 2017-04-11 Sumitomo Chemical Company, Limited Fused heterocyclic compound and use thereof for pest control
SG11201505587YA (en) 2013-01-23 2015-08-28 Aldeyra Therapeutics Inc Toxic aldehyde related diseases and treatment
WO2014116593A1 (en) 2013-01-25 2014-07-31 Aldexa Therapeutics, Inc. Novel traps in the treatment of macular degeneration
WO2016021706A1 (ja) * 2014-08-08 2016-02-11 カズマパートナーズ株式会社 縮合複素環化合物
EP3189026B1 (en) 2014-09-02 2020-07-22 The Regents of The University of California Estrogen receptor ligand treatment for neurodegenerative diseases
CN104974103A (zh) * 2015-07-14 2015-10-14 佛山市赛维斯医药科技有限公司 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途
CN104926745A (zh) * 2015-07-14 2015-09-23 佛山市赛维斯医药科技有限公司 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途
EP4400106A1 (en) 2015-08-21 2024-07-17 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
ES2968462T3 (es) 2017-03-16 2024-05-09 Aldeyra Therapeutics Inc Sal polimórfica de 6-cloro-3-amino-2(2-hidroxiprolil) quinolina y usos de la misma
US11040039B2 (en) 2017-10-10 2021-06-22 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
CN108586374B (zh) * 2018-01-12 2021-01-05 浙江鼎龙科技有限公司 2-苯基苯并噁唑类化合物的制备方法
EP3833660A4 (en) 2018-08-06 2022-05-11 Aldeyra Therapeutics, Inc. POLYMORPHIC COMPOUNDS AND THEIR USES
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
JP2022530967A (ja) 2019-05-02 2022-07-05 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
CN111467341B (zh) * 2020-04-24 2021-05-11 山东师范大学 3,4-二甲氧基苯基-苯并[d]恶唑作为肿瘤耐药逆转剂的应用
JP2023526016A (ja) 2020-05-13 2023-06-20 アルデイラ セラピューティクス, インコーポレイテッド 医薬製剤およびその使用
CN114805112A (zh) * 2022-05-31 2022-07-29 常州大学 一种pde2抑制剂酰胺类衍生物及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1435721A (en) * 1972-05-18 1976-05-12 Lilly Industries Ltd Benzoxazole derivatives
GB1590587A (en) 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IL113472A0 (en) * 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
DK0792292T4 (da) 1995-09-08 2009-07-20 Karobio Ab Orphan-receptor
US5919808A (en) 1996-10-23 1999-07-06 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5948776A (en) 1996-10-23 1999-09-07 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
EP0973513A4 (en) 1996-10-23 2003-03-19 Zymogenetics Inc COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH BONE DEFICIT
US7157568B1 (en) 1997-08-05 2007-01-02 American Home Products Corporation Human estrogen receptor-β
EE04641B1 (et) 1998-05-05 2006-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Bensimidasoolid ja bensoksasoolid, nende kasutamine hingamisteede ja dermatooside raviks ette nähtud ravimite valmistamiseks ning neid sisaldav ravim
ATE263166T1 (de) 1998-07-06 2004-04-15 Altana Pharma Ag Neue benzoxazole mit pde-hemmender wirkung
GB9814620D0 (en) 1998-07-06 1998-09-02 Karobio Ab Vasculoprotector
WO2000019994A1 (en) 1998-10-02 2000-04-13 Board Of Trustees Of The University Of Illinois Estrogen receptor ligands
WO2000031112A1 (en) 1998-11-20 2000-06-02 Akzo Nobel N.V. Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11
ES2207982T3 (es) 1998-12-30 2004-06-01 Signal Pharmaceuticals, Inc. Compuestos y metodos para la modulacion de receptores estrogenicos.
US6331562B1 (en) 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6358943B1 (en) * 1999-03-04 2002-03-19 American Home Products Corporation N-substituted indolines as estrogenic agents
CA2367895A1 (en) * 1999-03-17 2000-09-21 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AU3964400A (en) 1999-04-06 2000-10-23 Akzo Nobel N.V. Selective estrogenic compounds
AU4546900A (en) 1999-04-09 2000-11-14 Karo Bio Ab Estrogen receptors and bone
TR200102992T2 (tr) 1999-04-16 2004-12-21 Astrazeneca Ab ß östrojen reseptörü ligandları.
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy
GB9913649D0 (en) 1999-06-11 1999-08-11 Karobio Ab Estrogen receptor
US6380166B1 (en) * 1999-09-13 2002-04-30 American Home Products Corporation Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols
CA2400626C (en) 2000-02-14 2010-06-01 Merck & Co., Inc. Estrogen receptor modulators
JP2004515496A (ja) * 2000-12-07 2004-05-27 アストラゼネカ・アクチエボラーグ ベンズイミダゾール治療剤
JP2004524289A (ja) * 2000-12-22 2004-08-12 アストラゼネカ・アクチエボラーグ 治療化合物
US6559177B2 (en) 2001-04-19 2003-05-06 Wyeth 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
UA83620C2 (uk) * 2001-12-05 2008-08-11 Уайт Заміщені бензоксазоли та їх аналоги як естрогенні агенти
TW200612925A (en) * 2004-08-26 2006-05-01 Wyeth Corp Prodrug substituted benzoxazoles as estrogenic agents

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