ZA200403903B - Method for detecting analyte(s) using magnetic collodial particles. - Google Patents
Method for detecting analyte(s) using magnetic collodial particles. Download PDFInfo
- Publication number
- ZA200403903B ZA200403903B ZA200403903A ZA200403903A ZA200403903B ZA 200403903 B ZA200403903 B ZA 200403903B ZA 200403903 A ZA200403903 A ZA 200403903A ZA 200403903 A ZA200403903 A ZA 200403903A ZA 200403903 B ZA200403903 B ZA 200403903B
- Authority
- ZA
- South Africa
- Prior art keywords
- analyte
- particles
- magnetic
- colloidal particles
- magnetic field
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims description 81
- 230000005291 magnetic effect Effects 0.000 title claims description 72
- 239000012491 analyte Substances 0.000 title claims description 53
- 238000000034 method Methods 0.000 title claims description 52
- 239000003446 ligand Substances 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000006249 magnetic particle Substances 0.000 claims description 10
- 239000011554 ferrofluid Substances 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- 108010090804 Streptavidin Proteins 0.000 claims description 7
- 229960002685 biotin Drugs 0.000 claims description 7
- 239000011616 biotin Substances 0.000 claims description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 235000020958 biotin Nutrition 0.000 claims description 6
- 238000012512 characterization method Methods 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
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- 239000012074 organic phase Substances 0.000 claims description 3
- 108090001008 Avidin Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 2
- 108010017384 Blood Proteins Proteins 0.000 claims description 2
- 102000004506 Blood Proteins Human genes 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
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- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 239000013566 allergen Substances 0.000 claims description 2
- 239000003114 blood coagulation factor Substances 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000975 co-precipitation Methods 0.000 claims description 2
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- 239000007850 fluorescent dye Substances 0.000 claims description 2
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- 239000000243 solution Substances 0.000 description 17
- 238000001514 detection method Methods 0.000 description 15
- 238000003556 assay Methods 0.000 description 14
- 230000004520 agglutination Effects 0.000 description 13
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 9
- 238000007818 agglutination assay Methods 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
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- 238000001000 micrograph Methods 0.000 description 7
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- 241000894007 species Species 0.000 description 7
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 235000013980 iron oxide Nutrition 0.000 description 5
- 239000000696 magnetic material Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 102100036537 von Willebrand factor Human genes 0.000 description 5
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- 230000004523 agglutinating effect Effects 0.000 description 3
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- 230000008901 benefit Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241001415846 Procellariidae Species 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 150000001615 biotins Chemical class 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical class [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
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- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000036046 immunoreaction Effects 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229910000480 nickel oxide Inorganic materials 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Nanotechnology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0115011A FR2832507B1 (fr) | 2001-11-20 | 2001-11-20 | Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403903B true ZA200403903B (en) | 2005-06-23 |
Family
ID=8869592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403903A ZA200403903B (en) | 2001-11-20 | 2004-05-20 | Method for detecting analyte(s) using magnetic collodial particles. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7332353B2 (ja) |
| EP (1) | EP1446666B1 (ja) |
| JP (1) | JP2005517899A (ja) |
| KR (1) | KR20050044559A (ja) |
| CN (1) | CN100501403C (ja) |
| AT (1) | ATE431553T1 (ja) |
| AU (1) | AU2002361324A1 (ja) |
| BR (1) | BR0214233A (ja) |
| CA (1) | CA2467050A1 (ja) |
| DE (1) | DE60232353D1 (ja) |
| ES (1) | ES2325917T3 (ja) |
| FR (1) | FR2832507B1 (ja) |
| HU (1) | HU225636B1 (ja) |
| MX (1) | MXPA04004679A (ja) |
| NO (1) | NO20042579L (ja) |
| PL (1) | PL368690A1 (ja) |
| RU (1) | RU2004118490A (ja) |
| WO (1) | WO2003044532A1 (ja) |
| ZA (1) | ZA200403903B (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2878960A1 (fr) * | 2004-12-08 | 2006-06-09 | Centre Nat Rech Scient | Procede pour mettre en oeuvre un test d'agglutination dans un microcanal |
| US9733315B2 (en) * | 2005-07-27 | 2017-08-15 | University Of Houston | Nanomagnetic detector array for biomolecular recognition |
| CA2620861C (en) | 2005-08-31 | 2016-07-05 | T2 Biosystems, Inc. | Nmr device for detection of analytes |
| US8586389B2 (en) * | 2005-09-28 | 2013-11-19 | Kent State University | Ligand concentrating, liquid crystal biosensor system |
| WO2007085980A1 (en) | 2006-01-25 | 2007-08-02 | Koninklijke Philips Electronics N. V. | Device for analyzing fluids |
| KR100738496B1 (ko) * | 2006-07-27 | 2007-07-11 | 한양대학교 산학협력단 | 자성 미세입자 및 배향성 고정화 리간드를 이용한 항체단백질 분리방법 |
| US8368402B2 (en) * | 2006-11-08 | 2013-02-05 | T2 Biosystems, Inc. | NMR systems for in vivo detection of analytes |
| KR100823684B1 (ko) * | 2006-12-06 | 2008-04-21 | 한국전자통신연구원 | 바코드 ｄｎａ를 이용한 생물학적 표적 물질의 검출 방법 |
| FR2919390B1 (fr) | 2007-07-27 | 2009-10-30 | Bertin Technologies Soc Par Ac | Procede de dosage d'un analyte dans un milieu liquide |
| AU2008325088A1 (en) * | 2007-11-06 | 2009-05-14 | T2 Biosystems, Inc. | Small magnet and RF coil for magnetic resonance relaxometry |
| US20100323457A1 (en) * | 2007-12-03 | 2010-12-23 | Tokyo Institute Of Technology | Biosensing method using coated magnetic fine particles and biosensing apparatus for biosensing method |
| FR2928656B1 (fr) * | 2008-03-14 | 2011-08-26 | Biomerieux Sa | Procede de detection en temps reel de microorganismes dans un milieu de culture liquide par agglutination. |
| CA2741550C (en) | 2008-10-29 | 2018-12-04 | T2 Biosystems, Inc. | Nmr detection of coagulation time |
| EP2492665A1 (en) * | 2009-10-19 | 2012-08-29 | Tokyo Institute of Technology | Biosensor using magnetic microparticles |
| US9023607B2 (en) * | 2010-04-26 | 2015-05-05 | Intellectual Discovery Co., Ltd. | Method for early diagnosis of alzheimer'S disease using phototransistor |
| FR2959820B1 (fr) * | 2010-05-10 | 2013-03-15 | Bertin Technologies Sa | Procede de dosage d'un analyte dans un milieu liquide |
| CA3155334A1 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | NMR SYSTEMS AND METHODS FOR RAPID ANALYTE DETECTION |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| EP2541250A1 (en) | 2011-06-30 | 2013-01-02 | Koninklijke Philips Electronics N.V. | Molecular architecture on magnetic particles for affinity assays with low non-specific binding |
| WO2013010080A1 (en) | 2011-07-13 | 2013-01-17 | T2 Biosystems, Inc. | Nmr methods for monitoring blood clot formation |
| US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
| DE102011089798B4 (de) | 2011-12-23 | 2021-06-10 | Biophysical Tools GmbH | Massiv paralleler Test molekularer Wechselwirkungen basierend auf magnetischen Nano- und Mikropartikeln |
| FR2986617B1 (fr) | 2012-02-02 | 2015-03-27 | Horiba Abx Sas | Dispositif et procede pour effectuer des mesures hematologiques et biochimiques a partir d'un echantillon biologique |
| EP2839038B1 (en) | 2012-04-20 | 2019-01-16 | T2 Biosystems, Inc. | Compositions and methods for detection of candida species |
| EP2929047A4 (en) | 2012-12-07 | 2016-08-03 | T2 Biosystems Inc | METHOD FOR MONITORING THE FORMING OF SEALED GERINNSELN |
| CN108697141A (zh) * | 2015-12-29 | 2018-10-23 | N·V·努特里奇亚 | 含有不可消化寡糖和非复制型产乳酸细菌的营养配方物 |
| AU2017210033B2 (en) | 2016-01-21 | 2022-09-29 | T2 Biosystems, Inc. | NMR methods and systems for the rapid detection of bacteria |
| US11585882B2 (en) * | 2018-04-11 | 2023-02-21 | Mars Sciences Limited | Superparamagnetic particle imaging and its applications in quantitative multiplex stationary phase diagnostic assays |
| JP7264998B2 (ja) * | 2018-05-30 | 2023-04-25 | セプマグ、システムズ、ソシエダッド、リミターダ | 生物学的及び化学的物質を検出するための光磁気泳動法 |
| EP3824484A1 (en) * | 2018-07-19 | 2021-05-26 | Beckman Coulter Inc. | Magnetic particles |
| EP4305198A1 (en) | 2021-03-09 | 2024-01-17 | Etablissement Français du Sang | Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK140815B (da) * | 1975-06-10 | 1979-11-19 | Weeke Bengt | Fremgangsmåde til påvisning eller bestemmelse af antistoffer i legemsvæsker ved hjælp af kendte antigener eller til bestemmelse af antigener ved hjælp af kendte antistoffer fra legemsvæsker samt et middel til anvendelse ved udøvelse af fremgangsmåden. |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4622298A (en) * | 1984-08-09 | 1986-11-11 | Becton, Dickinson And Company | Detection and quantitation of microorganisms, leukocytes and squamous epithelial cells in urine |
| US5512332A (en) * | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US5639620A (en) * | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| WO1994009368A1 (en) * | 1992-10-15 | 1994-04-28 | Coulter Corporation | Particles having gelatin-aminodextran coatings of and processes for making same |
| US5298741A (en) * | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
| GB9524393D0 (en) * | 1995-11-29 | 1996-01-31 | Mini Agriculture & Fisheries | Extraction and labelling of materials |
| JP2001503859A (ja) * | 1996-10-15 | 2001-03-21 | バイオ―テック・イメイジング・インコーポレイテッド | Ｈｉｖ感染細胞の検出試薬系およびそのためのキット |
| US5817458A (en) * | 1996-10-15 | 1998-10-06 | The Avriel Group, Amcas Division Inc. | Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood |
| WO1998051435A1 (en) * | 1997-05-14 | 1998-11-19 | Weixin Tang | Fully-coated, uniform-sized metallic particles |
| WO1999033559A1 (en) * | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
| DE19822123C2 (de) * | 1997-11-21 | 2003-02-06 | Meinhard Knoll | Verfahren und Vorrichtung zum Nachweis von Analyten |
| ATE239801T1 (de) * | 1998-01-22 | 2003-05-15 | Luminex Corp | Mikropartikel mit multiplen fluoreszenz-signalen |
-
2001
- 2001-11-20 FR FR0115011A patent/FR2832507B1/fr not_active Expired - Fee Related
-
2002
- 2002-11-20 WO PCT/FR2002/003974 patent/WO2003044532A1/fr active Application Filing
- 2002-11-20 PL PL02368690A patent/PL368690A1/xx not_active Application Discontinuation
- 2002-11-20 DE DE60232353T patent/DE60232353D1/de not_active Expired - Lifetime
- 2002-11-20 BR BR0214233-3A patent/BR0214233A/pt not_active IP Right Cessation
- 2002-11-20 CA CA002467050A patent/CA2467050A1/fr not_active Abandoned
- 2002-11-20 AU AU2002361324A patent/AU2002361324A1/en not_active Abandoned
- 2002-11-20 JP JP2003546110A patent/JP2005517899A/ja active Pending
- 2002-11-20 RU RU2004118490/15A patent/RU2004118490A/ru not_active Application Discontinuation
- 2002-11-20 HU HU0402276A patent/HU225636B1/hu not_active IP Right Cessation
- 2002-11-20 KR KR1020047007733A patent/KR20050044559A/ko not_active Application Discontinuation
- 2002-11-20 EP EP02796851A patent/EP1446666B1/fr not_active Expired - Lifetime
- 2002-11-20 US US10/496,114 patent/US7332353B2/en not_active Expired - Fee Related
- 2002-11-20 ES ES02796851T patent/ES2325917T3/es not_active Expired - Lifetime
- 2002-11-20 CN CNB028230337A patent/CN100501403C/zh not_active Expired - Fee Related
- 2002-11-20 MX MXPA04004679A patent/MXPA04004679A/es not_active Application Discontinuation
- 2002-11-20 AT AT02796851T patent/ATE431553T1/de not_active IP Right Cessation
-
2004
- 2004-05-20 ZA ZA200403903A patent/ZA200403903B/en unknown
- 2004-06-18 NO NO20042579A patent/NO20042579L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004118490A (ru) | 2005-04-20 |
| ES2325917T3 (es) | 2009-09-24 |
| WO2003044532A1 (fr) | 2003-05-30 |
| EP1446666B1 (fr) | 2009-05-13 |
| EP1446666A1 (fr) | 2004-08-18 |
| ATE431553T1 (de) | 2009-05-15 |
| FR2832507B1 (fr) | 2004-02-20 |
| MXPA04004679A (es) | 2005-05-17 |
| DE60232353D1 (de) | 2009-06-25 |
| KR20050044559A (ko) | 2005-05-12 |
| AU2002361324A1 (en) | 2003-06-10 |
| US7332353B2 (en) | 2008-02-19 |
| HUP0402276A2 (hu) | 2005-02-28 |
| CA2467050A1 (fr) | 2003-05-30 |
| CN1589405A (zh) | 2005-03-02 |
| FR2832507A1 (fr) | 2003-05-23 |
| US20050048673A1 (en) | 2005-03-03 |
| CN100501403C (zh) | 2009-06-17 |
| JP2005517899A (ja) | 2005-06-16 |
| HU225636B1 (en) | 2007-05-02 |
| NO20042579L (no) | 2004-06-18 |
| HUP0402276A3 (en) | 2005-11-28 |
| BR0214233A (pt) | 2004-09-21 |
| PL368690A1 (en) | 2005-04-04 |
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