ZA200403328B - Oral dosage form of a sulfonamide prodrug such as parecoxid. - Google Patents

Info

Publication number

ZA200403328B

ZA200403328B ZA200403328A ZA200403328A ZA200403328B ZA 200403328 B ZA200403328 B ZA 200403328B ZA 200403328 A ZA200403328 A ZA 200403328A ZA 200403328 A ZA200403328 A ZA 200403328A ZA 200403328 B ZA200403328 B ZA 200403328B

Authority

ZA

South Africa

Prior art keywords

composition

parecoxib

water

valdecoxib

drug

Prior art date

2001-11-13

Links

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• 229940002612 prodrug Drugs 0.000 title description 31
• 229940124530 sulfonamide Drugs 0.000 title description 15
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• 239000006186 oral dosage form Substances 0.000 title description 5
• 239000000203 mixture Substances 0.000 claims description 141
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• 229960004662 parecoxib Drugs 0.000 claims description 107
• LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims description 63
• 229960002004 valdecoxib Drugs 0.000 claims description 61
• 239000003814 drug Substances 0.000 claims description 50
• 229940079593 drug Drugs 0.000 claims description 46
• 150000003839 salts Chemical class 0.000 claims description 43
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 33
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