ZA200403328B - Oral dosage form of a sulfonamide prodrug such as parecoxid. - Google Patents
Oral dosage form of a sulfonamide prodrug such as parecoxid. Download PDFInfo
- Publication number
- ZA200403328B ZA200403328B ZA200403328A ZA200403328A ZA200403328B ZA 200403328 B ZA200403328 B ZA 200403328B ZA 200403328 A ZA200403328 A ZA 200403328A ZA 200403328 A ZA200403328 A ZA 200403328A ZA 200403328 B ZA200403328 B ZA 200403328B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- parecoxib
- water
- valdecoxib
- drug
- Prior art date
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- 229940002612 prodrug Drugs 0.000 title description 31
- 229940124530 sulfonamide Drugs 0.000 title description 15
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- 229960004662 parecoxib Drugs 0.000 claims description 107
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims description 63
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- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 33
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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US35059601P | 2001-11-13 | 2001-11-13 |
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ZA200403328A ZA200403328B (en) | 2001-11-13 | 2004-05-03 | Oral dosage form of a sulfonamide prodrug such as parecoxid. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20030100595A1 (es) |
EP (1) | EP1446118B1 (es) |
JP (1) | JP2005509002A (es) |
KR (1) | KR20050044459A (es) |
CN (1) | CN1615135A (es) |
AR (1) | AR037356A1 (es) |
AT (1) | ATE383156T1 (es) |
BR (1) | BR0214081A (es) |
CA (1) | CA2466504A1 (es) |
CO (1) | CO5580744A2 (es) |
DE (1) | DE60224558T2 (es) |
ES (1) | ES2297032T3 (es) |
IL (1) | IL161991A0 (es) |
MX (1) | MXPA04004476A (es) |
NO (1) | NO20042440L (es) |
PL (1) | PL369962A1 (es) |
RU (1) | RU2004114552A (es) |
TW (1) | TW200300680A (es) |
WO (1) | WO2003041705A1 (es) |
ZA (1) | ZA200403328B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7785640B2 (en) * | 2004-01-16 | 2010-08-31 | Amerilab Technologies, Inc. | Effervescent composition including cranberry extract |
LT2801354T (lt) | 2004-10-08 | 2017-06-26 | Forward Pharma A/S | Kontroliuojamo atpalaidavimo farmacinės kompozicijos, apimančios fumaro rūgšties esterį |
US7964223B2 (en) * | 2005-09-27 | 2011-06-21 | University Of Kentucky Research Foundation | Berry preparations and extracts |
WO2007042035A2 (en) * | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
US20100047371A1 (en) * | 2006-08-29 | 2010-02-25 | Mumper Russell J | Compositions and methods for oral cancer chemoprevention using berry preparations and extracts |
EP1902708A1 (de) | 2006-09-25 | 2008-03-26 | Losan Pharma GmbH | Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung |
ES2377426T3 (es) * | 2007-10-12 | 2012-03-27 | Astrazeneca Ab | Composición de zibotentán que contiene manitol y celulosa microcristalina |
US8906420B2 (en) | 2009-01-09 | 2014-12-09 | Forward Pharma A/S | Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix |
JP6102120B2 (ja) * | 2012-08-16 | 2017-03-29 | ニプロ株式会社 | 医薬製剤およびその製造方法 |
CN104771370B (zh) * | 2014-01-14 | 2020-07-24 | 南京圣和药业股份有限公司 | 帕瑞昔布钠冻干粉针剂及其制备方法 |
CN104965041B (zh) * | 2015-06-11 | 2016-06-29 | 成都克莱蒙医药科技有限公司 | 一种帕瑞昔布钠异构体的高效液相色谱检测方法 |
CN106074399B (zh) * | 2016-06-21 | 2018-11-02 | 马鞍山丰原制药有限公司 | 一种帕瑞昔布钠冻干制剂及其制备方法 |
CN112409283A (zh) * | 2020-11-24 | 2021-02-26 | 苏州璞正医药有限公司 | 一种帕瑞昔布衍生物及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013794A1 (fr) * | 1993-11-18 | 1995-05-26 | Nippon Shinyaku Co., Ltd. | Procede pour produire une composition de medicament stable, et preparation pharmaceutique |
GB9523833D0 (en) * | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
EP0892791B1 (en) * | 1996-04-12 | 2003-03-05 | G.D. Searle & Co. | N-[[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL]PHENYL]SULFONYLPROPYLAMIDE and its SODIUMSALT AS PRODRUGS OF COX-2 INHIBITORS |
SE9703693D0 (sv) * | 1997-10-10 | 1997-10-10 | Astra Pharma Prod | Novel combination |
US6323226B1 (en) * | 1999-10-19 | 2001-11-27 | Texas Heart Institute | Treatment of heart disease with cox-2 inhibitors |
JP2003516353A (ja) * | 1999-12-08 | 2003-05-13 | ファルマシア コーポレイション | ヴァルデコキシブ組成物 |
MY127898A (en) * | 1999-12-22 | 2006-12-29 | Pharmacia Corp | Dual-release compositions of a cyclooxygenase-2 inhibitor |
US6403830B2 (en) * | 2000-03-24 | 2002-06-11 | Pharmacia Corporation | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
MY120279A (en) * | 2000-05-26 | 2005-09-30 | Pharmacia Corp | Use of a celecoxib composition for fast pain relief |
US6306842B1 (en) * | 2000-06-02 | 2001-10-23 | Medinox, Inc. | Protected forms of a combination of pharmacologically active agents and uses therefor |
JP2004503588A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 全身性疼痛および頭痛に対する選択的シクロオキシゲナーゼ−2阻害薬および血管調節化合物 |
MY137736A (en) * | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
-
2002
- 2002-11-12 RU RU2004114552/14A patent/RU2004114552A/ru not_active Application Discontinuation
- 2002-11-12 DE DE60224558T patent/DE60224558T2/de not_active Expired - Fee Related
- 2002-11-12 PL PL02369962A patent/PL369962A1/xx not_active Application Discontinuation
- 2002-11-12 US US10/292,682 patent/US20030100595A1/en not_active Abandoned
- 2002-11-12 EP EP02789593A patent/EP1446118B1/en not_active Expired - Lifetime
- 2002-11-12 CN CNA028270843A patent/CN1615135A/zh active Pending
- 2002-11-12 ES ES02789593T patent/ES2297032T3/es not_active Expired - Lifetime
- 2002-11-12 TW TW091133146A patent/TW200300680A/zh unknown
- 2002-11-12 AT AT02789593T patent/ATE383156T1/de not_active IP Right Cessation
- 2002-11-12 JP JP2003543592A patent/JP2005509002A/ja active Pending
- 2002-11-12 WO PCT/US2002/036253 patent/WO2003041705A1/en active IP Right Grant
- 2002-11-12 CA CA002466504A patent/CA2466504A1/en not_active Abandoned
- 2002-11-12 MX MXPA04004476A patent/MXPA04004476A/es active IP Right Grant
- 2002-11-12 IL IL16199102A patent/IL161991A0/xx unknown
- 2002-11-12 AR ARP020104341A patent/AR037356A1/es unknown
- 2002-11-12 KR KR1020047007335A patent/KR20050044459A/ko not_active Application Discontinuation
- 2002-11-12 BR BR0214081-0A patent/BR0214081A/pt not_active IP Right Cessation
-
2004
- 2004-05-03 ZA ZA200403328A patent/ZA200403328B/en unknown
- 2004-05-07 CO CO04042439A patent/CO5580744A2/es not_active Application Discontinuation
- 2004-06-11 NO NO20042440A patent/NO20042440L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1446118B1 (en) | 2008-01-09 |
ATE383156T1 (de) | 2008-01-15 |
IL161991A0 (en) | 2005-11-20 |
EP1446118A1 (en) | 2004-08-18 |
AR037356A1 (es) | 2004-11-03 |
DE60224558T2 (de) | 2009-01-22 |
CO5580744A2 (es) | 2005-11-30 |
JP2005509002A (ja) | 2005-04-07 |
WO2003041705A1 (en) | 2003-05-22 |
DE60224558D1 (de) | 2008-02-21 |
KR20050044459A (ko) | 2005-05-12 |
ES2297032T3 (es) | 2008-05-01 |
MXPA04004476A (es) | 2004-08-11 |
TW200300680A (en) | 2003-06-16 |
PL369962A1 (en) | 2005-05-02 |
CN1615135A (zh) | 2005-05-11 |
CA2466504A1 (en) | 2003-05-22 |
NO20042440L (no) | 2004-08-09 |
RU2004114552A (ru) | 2005-02-20 |
US20030100595A1 (en) | 2003-05-29 |
BR0214081A (pt) | 2004-09-28 |
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