ZA200402947B - Benzimidazoles useful as protein kinase inhibitors. - Google Patents
Benzimidazoles useful as protein kinase inhibitors. Download PDFInfo
- Publication number
- ZA200402947B ZA200402947B ZA200402947A ZA200402947A ZA200402947B ZA 200402947 B ZA200402947 B ZA 200402947B ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 B ZA200402947 B ZA 200402947B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- chosen
- compound according
- phenyl
- optionally substituted
- Prior art date
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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FR2833948B1 (fr) | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
US20050176792A1 (en) * | 2004-01-14 | 2005-08-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Ketone substituted benzimidazole compounds |
WO2005079791A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
EP1828144A2 (en) * | 2004-11-12 | 2007-09-05 | OSI Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
WO2006068105A1 (ja) * | 2004-12-20 | 2006-06-29 | Santen Pharmaceutical Co., Ltd. | 角結膜障害治療剤 |
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EP1879881A2 (en) * | 2005-04-14 | 2008-01-23 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
GB0515025D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
EP1957491A2 (en) * | 2005-11-12 | 2008-08-20 | Boehringer Ingelheim International GmbH | Pyrrolo (2,3-b) pyridine derivatives useful as tec kinase inhibitors |
US20110071130A1 (en) * | 2006-05-08 | 2011-03-24 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
MX2010007418A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
EP2244706B1 (en) * | 2008-02-25 | 2016-04-06 | Merck Patent GmbH | Glucokinase activators |
US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
WO2010126743A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
US8450354B2 (en) | 2010-03-23 | 2013-05-28 | High Point Pharmaceuticals, Llc | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors |
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WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
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JO3300B1 (ar) * | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
US8828998B2 (en) * | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
EP2890691B1 (en) | 2012-08-31 | 2018-04-25 | Principia Biopharma Inc. | Benzimidazole derivatives as itk inhibitors |
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US10000469B2 (en) | 2014-03-25 | 2018-06-19 | Duke University | Heat shock protein 70 (hsp-70) receptor ligands |
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KR101560338B1 (ko) | 2014-04-21 | 2015-10-19 | 건국대학교 산학협력단 | 야누스 키나아제 1의 활성을 선택적으로 저해하는 벤조이미다졸 유도체 |
JP2019510802A (ja) * | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | タンパク質調節物質として有用な複素環アミド |
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JP5036112B2 (ja) * | 1999-10-06 | 2012-09-26 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | チロシンキナーゼのインヒビターとして有益な複素環化合物 |
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-
2002
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
- 2002-11-05 MX MXPA04004301A patent/MXPA04004301A/es unknown
- 2002-11-05 EA EA200400595A patent/EA200400595A1/ru unknown
- 2002-11-05 NZ NZ533310A patent/NZ533310A/xx unknown
- 2002-11-05 CA CA002464419A patent/CA2464419A1/en not_active Abandoned
- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 EP EP02789445A patent/EP1448199A1/en not_active Withdrawn
- 2002-11-05 IL IL16151602A patent/IL161516A0/xx unknown
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Application Discontinuation
- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
- 2002-11-05 YU YU37904A patent/YU37904A/sh unknown
- 2002-11-05 CN CNA028270002A patent/CN1612733A/zh active Pending
- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/en active IP Right Grant
-
2004
- 2004-04-19 ZA ZA200402947A patent/ZA200402947B/en unknown
- 2004-05-07 NO NO20041887A patent/NO20041887L/no unknown
- 2004-05-07 HR HR20040416A patent/HRP20040416A2/hr not_active Application Discontinuation
- 2004-06-01 CO CO04051014A patent/CO5580788A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20030144281A1 (en) | 2003-07-31 |
MXPA04004301A (es) | 2004-08-11 |
NZ533310A (en) | 2004-12-24 |
CO5580788A2 (es) | 2005-11-30 |
CN1612733A (zh) | 2005-05-04 |
EA200400595A1 (ru) | 2004-10-28 |
NO20041887L (no) | 2004-05-07 |
HRP20040416A2 (en) | 2005-04-30 |
KR20040063144A (ko) | 2004-07-12 |
EP1448199A1 (en) | 2004-08-25 |
US6825219B2 (en) | 2004-11-30 |
IL161516A0 (en) | 2004-09-27 |
CA2464419A1 (en) | 2003-05-22 |
YU37904A (sh) | 2006-08-17 |
JP2005509003A (ja) | 2005-04-07 |
WO2003041708A1 (en) | 2003-05-22 |
PL369771A1 (en) | 2005-05-02 |
BR0214019A (pt) | 2004-10-13 |
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