HRP20040416A2 - Benzimidazoles useful as protein kinase inhibitors - Google Patents
Benzimidazoles useful as protein kinase inhibitors Download PDFInfo
- Publication number
- HRP20040416A2 HRP20040416A2 HR20040416A HRP20040416A HRP20040416A2 HR P20040416 A2 HRP20040416 A2 HR P20040416A2 HR 20040416 A HR20040416 A HR 20040416A HR P20040416 A HRP20040416 A HR P20040416A HR P20040416 A2 HRP20040416 A2 HR P20040416A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- optionally substituted
- heteroaryl
- phenyl
- Prior art date
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- 150000001556 benzimidazoles Chemical class 0.000 title description 2
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 94
- 238000000034 method Methods 0.000 claims description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
- -1 sulfonylamino, aminosulfonyl Chemical group 0.000 claims description 31
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 125000002541 furyl group Chemical group 0.000 claims description 17
- 125000001544 thienyl group Chemical group 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
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- 239000001257 hydrogen Substances 0.000 claims description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims description 13
- 125000002883 imidazolyl group Chemical group 0.000 claims description 13
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
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WO2005079791A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
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US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
JP2012525389A (ja) | 2009-04-27 | 2012-10-22 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 置換イソキノリン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用方法 |
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- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
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- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 EP EP02789445A patent/EP1448199A1/en not_active Withdrawn
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Application Discontinuation
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- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 CA CA002464419A patent/CA2464419A1/en not_active Abandoned
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/en active IP Right Grant
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
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Also Published As
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WO2003041708A1 (en) | 2003-05-22 |
US20030144281A1 (en) | 2003-07-31 |
YU37904A (sh) | 2006-08-17 |
CA2464419A1 (en) | 2003-05-22 |
US6825219B2 (en) | 2004-11-30 |
BR0214019A (pt) | 2004-10-13 |
ZA200402947B (en) | 2005-01-24 |
MXPA04004301A (es) | 2004-08-11 |
IL161516A0 (en) | 2004-09-27 |
CO5580788A2 (es) | 2005-11-30 |
NO20041887L (no) | 2004-05-07 |
PL369771A1 (en) | 2005-05-02 |
EP1448199A1 (en) | 2004-08-25 |
EA200400595A1 (ru) | 2004-10-28 |
JP2005509003A (ja) | 2005-04-07 |
KR20040063144A (ko) | 2004-07-12 |
CN1612733A (zh) | 2005-05-04 |
NZ533310A (en) | 2004-12-24 |
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