ZA200402812B - Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine A2a receptor antagonists. - Google Patents
Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine A2a receptor antagonists. Download PDFInfo
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- ZA200402812B ZA200402812B ZA200402812A ZA200402812A ZA200402812B ZA 200402812 B ZA200402812 B ZA 200402812B ZA 200402812 A ZA200402812 A ZA 200402812A ZA 200402812 A ZA200402812 A ZA 200402812A ZA 200402812 B ZA200402812 B ZA 200402812B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkoxy
- compound
- phenyl
- group
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32956701P | 2001-10-15 | 2001-10-15 |
Publications (1)
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| ZA200402812B true ZA200402812B (en) | 2005-04-25 |
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| ZA200402812A ZA200402812B (en) | 2001-10-15 | 2004-04-13 | Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine A2a receptor antagonists. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6653315B2 (de) |
| EP (1) | EP1435960B1 (de) |
| JP (2) | JP4545437B2 (de) |
| KR (1) | KR100687954B1 (de) |
| CN (1) | CN100421663C (de) |
| AR (1) | AR037243A1 (de) |
| AU (1) | AU2002340184B2 (de) |
| CA (1) | CA2463598C (de) |
| HU (1) | HUP0401777A3 (de) |
| IL (1) | IL160878A0 (de) |
| MX (1) | MXPA04003474A (de) |
| MY (1) | MY124864A (de) |
| NZ (1) | NZ531761A (de) |
| PE (1) | PE20030477A1 (de) |
| WO (1) | WO2003032996A1 (de) |
| ZA (1) | ZA200402812B (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1453836B1 (de) * | 2001-11-30 | 2007-03-28 | Schering Corporation | BICYCLISCHE [1,2,4|-TRIAZOL ADENOSIN A2a REZEPTOR ANTAGONISTEN |
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2002
- 2002-10-11 AU AU2002340184A patent/AU2002340184B2/en not_active Ceased
- 2002-10-11 AR ARP020103834A patent/AR037243A1/es unknown
- 2002-10-11 JP JP2003535799A patent/JP4545437B2/ja not_active Expired - Fee Related
- 2002-10-11 KR KR1020047005369A patent/KR100687954B1/ko not_active IP Right Cessation
- 2002-10-11 CN CNB028203283A patent/CN100421663C/zh not_active Expired - Fee Related
- 2002-10-11 HU HU0401777A patent/HUP0401777A3/hu unknown
- 2002-10-11 MY MYPI20023804A patent/MY124864A/en unknown
- 2002-10-11 US US10/269,754 patent/US6653315B2/en not_active Expired - Lifetime
- 2002-10-11 NZ NZ531761A patent/NZ531761A/en unknown
- 2002-10-11 WO PCT/US2002/032630 patent/WO2003032996A1/en active IP Right Grant
- 2002-10-11 IL IL16087802A patent/IL160878A0/xx unknown
- 2002-10-11 PE PE2002001009A patent/PE20030477A1/es not_active Application Discontinuation
- 2002-10-11 CA CA002463598A patent/CA2463598C/en not_active Expired - Fee Related
- 2002-10-11 EP EP02778530.2A patent/EP1435960B1/de not_active Expired - Lifetime
- 2002-10-11 MX MXPA04003474A patent/MXPA04003474A/es active IP Right Grant
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| Publication number | Publication date |
|---|---|
| AR037243A1 (es) | 2004-11-03 |
| AU2002340184B2 (en) | 2005-10-06 |
| JP4545437B2 (ja) | 2010-09-15 |
| CN100421663C (zh) | 2008-10-01 |
| US20030171381A1 (en) | 2003-09-11 |
| MY124864A (en) | 2006-07-31 |
| JP2005506352A (ja) | 2005-03-03 |
| KR100687954B1 (ko) | 2007-02-27 |
| EP1435960B1 (de) | 2014-07-30 |
| US6653315B2 (en) | 2003-11-25 |
| MXPA04003474A (es) | 2004-07-30 |
| KR20050035155A (ko) | 2005-04-15 |
| IL160878A0 (en) | 2004-08-31 |
| CN1612736A (zh) | 2005-05-04 |
| WO2003032996A1 (en) | 2003-04-24 |
| CA2463598C (en) | 2009-09-08 |
| JP2008297312A (ja) | 2008-12-11 |
| HUP0401777A2 (hu) | 2004-12-28 |
| PE20030477A1 (es) | 2003-06-06 |
| NZ531761A (en) | 2005-10-28 |
| CA2463598A1 (en) | 2003-04-24 |
| EP1435960A1 (de) | 2004-07-14 |
| HUP0401777A3 (en) | 2008-06-30 |
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