ZA200401796B - Benzothiazepine derivatives for the treatment of hyperlipidaemia. - Google Patents
Benzothiazepine derivatives for the treatment of hyperlipidaemia. Download PDFInfo
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- ZA200401796B ZA200401796B ZA200401796A ZA200401796A ZA200401796B ZA 200401796 B ZA200401796 B ZA 200401796B ZA 200401796 A ZA200401796 A ZA 200401796A ZA 200401796 A ZA200401796 A ZA 200401796A ZA 200401796 B ZA200401796 B ZA 200401796B
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- South Africa
- Prior art keywords
- formula
- solvate
- compound
- salt
- pharmaceutically acceptable
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims description 37
- 208000031226 Hyperlipidaemia Diseases 0.000 title description 7
- 150000007657 benzothiazepines Chemical class 0.000 title description 7
- 229940085242 benzothiazepine derivative selective calcium channel blockers with direct cardiac effects Drugs 0.000 title description 4
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- 125000001424 substituent group Chemical group 0.000 claims description 26
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- 229910052791 calcium Inorganic materials 0.000 description 1
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- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
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- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 125000005633 phthalidyl group Chemical group 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121621.7A GB0121621D0 (en) | 2001-09-07 | 2001-09-07 | Chemical compounds |
Publications (1)
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|---|---|
| ZA200401796B true ZA200401796B (en) | 2005-04-08 |
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| ZA200401796A ZA200401796B (en) | 2001-09-07 | 2004-03-04 | Benzothiazepine derivatives for the treatment of hyperlipidaemia. |
Country Status (19)
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|---|---|
| US (1) | US7125864B2 (de) |
| EP (1) | EP1427713B1 (de) |
| JP (1) | JP4494780B2 (de) |
| KR (1) | KR20040031057A (de) |
| CN (1) | CN1639140A (de) |
| AT (1) | ATE454379T1 (de) |
| AU (1) | AU2002331927B2 (de) |
| BR (1) | BR0212344A (de) |
| CA (1) | CA2459457A1 (de) |
| DE (1) | DE60235019D1 (de) |
| ES (1) | ES2337559T3 (de) |
| GB (1) | GB0121621D0 (de) |
| IL (1) | IL160689A0 (de) |
| MX (1) | MXPA04002189A (de) |
| NO (1) | NO20040954L (de) |
| NZ (1) | NZ531797A (de) |
| UY (1) | UY27437A1 (de) |
| WO (1) | WO2003022825A1 (de) |
| ZA (1) | ZA200401796B (de) |
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| AU2002329387B2 (en) | 2001-09-08 | 2007-06-07 | Albireo Ab | Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment hyperlipidaemia |
| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| BR0311932A (pt) * | 2002-06-20 | 2005-03-22 | Astrazeneca Ab | Composto, formulação farmacêutica, método para tratar ou prevenir resistência à insulina, uso de um composto, processo para preparar um composto, e, tratamento combinado |
| US7312208B2 (en) | 2002-08-28 | 2007-12-25 | Asahi Kasei Pharma Corporation | Quaternary ammonium compounds |
| GB0304194D0 (en) * | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| GB0314131D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| KR20070026392A (ko) * | 2004-02-27 | 2007-03-08 | 아사히 가세이 파마 가부시키가이샤 | 신규 벤조티아제핀 및 벤조티에핀 화합물 |
| US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| AR057828A1 (es) * | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
| DE102006053635B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| RU2480453C2 (ru) | 2007-03-08 | 2013-04-27 | Альбирео Аб | Новые соединения |
| WO2010062861A2 (en) * | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| DK2637646T3 (en) | 2010-11-08 | 2016-08-29 | Albireo Ab | PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| EP3012252A1 (de) | 2014-10-24 | 2016-04-27 | Ferring BV | Kristalline Form von elobixibat |
| WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| EP3664782B1 (de) | 2017-08-09 | 2025-01-29 | Albireo AB | Cholestyraminpellets, orale cholestyraminformulierungen und ihre medizinische verwendung |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| CA3091338A1 (en) | 2018-03-09 | 2019-09-12 | Elobix Ab | Process for the preparation of elobixibat |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
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2002
- 2002-09-05 KR KR10-2004-7003331A patent/KR20040031057A/ko not_active Ceased
- 2002-09-05 IL IL16068902A patent/IL160689A0/xx unknown
- 2002-09-05 BR BR0212344-4A patent/BR0212344A/pt not_active IP Right Cessation
- 2002-09-05 JP JP2003526900A patent/JP4494780B2/ja not_active Expired - Fee Related
- 2002-09-05 NZ NZ531797A patent/NZ531797A/en unknown
- 2002-09-05 EP EP02767623A patent/EP1427713B1/de not_active Expired - Lifetime
- 2002-09-05 AU AU2002331927A patent/AU2002331927B2/en not_active Ceased
- 2002-09-05 WO PCT/GB2002/004043 patent/WO2003022825A1/en not_active Ceased
- 2002-09-05 MX MXPA04002189A patent/MXPA04002189A/es active IP Right Grant
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- 2002-09-05 DE DE60235019T patent/DE60235019D1/de not_active Expired - Lifetime
- 2002-09-05 AT AT02767623T patent/ATE454379T1/de not_active IP Right Cessation
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- 2004-03-04 ZA ZA200401796A patent/ZA200401796B/en unknown
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| WO2003022825A1 (en) | 2003-03-20 |
| JP4494780B2 (ja) | 2010-06-30 |
| ES2337559T3 (es) | 2010-04-27 |
| NZ531797A (en) | 2005-11-25 |
| IL160689A0 (en) | 2004-08-31 |
| UY27437A1 (es) | 2003-04-30 |
| US7125864B2 (en) | 2006-10-24 |
| GB0121621D0 (en) | 2001-10-31 |
| KR20040031057A (ko) | 2004-04-09 |
| AU2002331927B2 (en) | 2008-02-21 |
| EP1427713A1 (de) | 2004-06-16 |
| CA2459457A1 (en) | 2003-03-20 |
| DE60235019D1 (de) | 2010-02-25 |
| ATE454379T1 (de) | 2010-01-15 |
| CN1639140A (zh) | 2005-07-13 |
| EP1427713B1 (de) | 2010-01-06 |
| JP2005503401A (ja) | 2005-02-03 |
| MXPA04002189A (es) | 2004-06-29 |
| BR0212344A (pt) | 2004-10-19 |
| NO20040954L (no) | 2004-03-04 |
| US20050032776A1 (en) | 2005-02-10 |
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