ZA200307439B - Melanocortin receptor ligands. - Google Patents
Melanocortin receptor ligands. Download PDFInfo
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- ZA200307439B ZA200307439B ZA200307439A ZA200307439A ZA200307439B ZA 200307439 B ZA200307439 B ZA 200307439B ZA 200307439 A ZA200307439 A ZA 200307439A ZA 200307439 A ZA200307439 A ZA 200307439A ZA 200307439 B ZA200307439 B ZA 200307439B
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- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
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- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28661001P | 2001-04-25 | 2001-04-25 |
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| Publication Number | Publication Date |
|---|---|
| ZA200307439B true ZA200307439B (en) | 2004-10-06 |
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| ZA200307439A ZA200307439B (en) | 2001-04-25 | 2003-09-25 | Melanocortin receptor ligands. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6911447B2 (ko) |
| EP (1) | EP1390361A4 (ko) |
| JP (1) | JP2005503342A (ko) |
| KR (2) | KR100662309B1 (ko) |
| CN (1) | CN1543461A (ko) |
| AR (1) | AR035863A1 (ko) |
| AU (1) | AU2002254744B2 (ko) |
| BR (1) | BR0209193A (ko) |
| CA (1) | CA2444599A1 (ko) |
| CZ (1) | CZ20032806A3 (ko) |
| HU (1) | HUP0500870A3 (ko) |
| IL (1) | IL157969A0 (ko) |
| MA (1) | MA27016A1 (ko) |
| MX (1) | MXPA03009791A (ko) |
| NO (1) | NO20034774L (ko) |
| NZ (1) | NZ528262A (ko) |
| PE (1) | PE20021087A1 (ko) |
| PL (1) | PL373503A1 (ko) |
| RU (1) | RU2277535C2 (ko) |
| SK (1) | SK13222003A3 (ko) |
| WO (1) | WO2002085925A2 (ko) |
| ZA (1) | ZA200307439B (ko) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| CA2453515A1 (en) | 2001-07-11 | 2003-01-23 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptides |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US6974187B2 (en) * | 2004-01-28 | 2005-12-13 | Tachi-S Co., Ltd. | Vehicle seat structure |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| FR2870244B1 (fr) | 2004-05-11 | 2011-01-07 | Centre Nat Rech Scient | Conjugues dipeptidiques antagonistes de l'alpha-msh |
| FR2870242B1 (fr) * | 2004-05-11 | 2010-08-20 | Inst Europeen Biologie Cellulaire | Peptides ou conjugues peptidiques derives de la msh et leur utilisation dans le traitement cosmetique de la canitie. |
| FR2870243B1 (fr) | 2004-05-11 | 2010-11-19 | Centre Nat Rech Scient | Conjugues tripeptidiques agonistes de la msh |
| WO2006034341A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| US7592343B2 (en) * | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
| US8071603B2 (en) * | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AR051294A1 (es) * | 2004-09-20 | 2007-01-03 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| CA2580787A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| EP1799668A1 (en) * | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| BRPI0515488A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| US20080167321A1 (en) * | 2004-09-20 | 2008-07-10 | Xenon Pharmaceuticals Inc. | Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase |
| JP4731495B2 (ja) * | 2004-12-13 | 2011-07-27 | ルネサスエレクトロニクス株式会社 | 半導体装置 |
| BRPI0611187A2 (pt) * | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| US7964181B2 (en) * | 2006-03-30 | 2011-06-21 | Palatin Technologies, Inc. | Amino acid surrogates for peptidic constructs |
| EA200802060A1 (ru) * | 2006-03-30 | 2009-10-30 | Палатин Текнолоджиз, Инк. | Суррогаты аминокислот для пептидных конструктов |
| US8114844B2 (en) | 2006-03-30 | 2012-02-14 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptidomimetics |
| US7795221B2 (en) | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| WO2007115175A2 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| WO2008017852A1 (en) * | 2006-08-11 | 2008-02-14 | Palatin Technologies, Inc. | Diamine-containing, tetra- substituted piperazine compounds as melanocortin receptor modulators |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| WO2010056717A1 (en) | 2008-11-17 | 2010-05-20 | Merck Sharp & Dohme Corp. | Substituted bicyclic amines for the treatment of diabetes |
| CA2743700C (en) * | 2008-12-15 | 2016-07-12 | Taigen Biotechnology Co., Ltd. | Stereoselective synthesis of piperidine derivatives |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| WO2011011508A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CN102093260B (zh) * | 2009-12-14 | 2014-03-05 | 太景生物科技股份有限公司 | 哌啶衍生物的立体有择合成 |
| US8476227B2 (en) | 2010-01-22 | 2013-07-02 | Ethicon Endo-Surgery, Inc. | Methods of activating a melanocortin-4 receptor pathway in obese subjects |
| US9044606B2 (en) | 2010-01-22 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Methods and devices for activating brown adipose tissue using electrical energy |
| US8785634B2 (en) | 2010-04-26 | 2014-07-22 | Merck Sharp & Dohme Corp | Spiropiperidine prolylcarboxypeptidase inhibitors |
| EP2568812B1 (en) | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US10080884B2 (en) | 2014-12-29 | 2018-09-25 | Ethicon Llc | Methods and devices for activating brown adipose tissue using electrical energy |
| US10092738B2 (en) | 2014-12-29 | 2018-10-09 | Ethicon Llc | Methods and devices for inhibiting nerves when activating brown adipose tissue |
| PL3333165T3 (pl) * | 2015-08-04 | 2019-12-31 | Astellas Pharma Inc. | Pochodne piperazyny |
| CN108742570B (zh) * | 2018-06-20 | 2021-10-01 | 博动医学影像科技（上海）有限公司 | 基于冠脉优势类型获取血管压力差的装置 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534536B1 (en) * | 1994-03-16 | 2003-03-18 | Bristol-Myers Squibb Company | Alkylsulfonamido heterocyclic thrombin inhibitors |
| US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| CZ151495A3 (en) | 1992-12-11 | 1995-12-13 | Merck & Co Inc | Spiropiperidine derivatives, process of their preparation and a pharmaceutical composition containing thereof |
| US5536716A (en) | 1992-12-11 | 1996-07-16 | Merck & Co., Inc. | Spiro piperidines and homologs which promote release of growth hormone |
| US5494919A (en) * | 1993-11-09 | 1996-02-27 | Merck & Co., Inc. | 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5721251A (en) * | 1993-12-10 | 1998-02-24 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5783582A (en) * | 1994-07-20 | 1998-07-21 | Merck & Co., Inc. | Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone |
| US5767118A (en) | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
| EP0828754B1 (en) * | 1995-05-29 | 2005-02-02 | Pfizer Inc. | Dipeptides which promote release of growth hormone |
| GB9612276D0 (en) * | 1996-06-12 | 1996-08-14 | Merck & Co Inc | 4-Spiroindoline piperidines promote release of growth hormone |
| US5804578A (en) * | 1996-04-03 | 1998-09-08 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5877182A (en) * | 1996-09-13 | 1999-03-02 | Merck & Co., Inc. | Piperidines promote release of growth hormone |
| WO1998010653A1 (en) | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| US5965565A (en) * | 1996-12-12 | 1999-10-12 | Merck & Co., Inc. | Piperidines promote release of growth hormone |
| EP1076649A4 (en) | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| PL194560B1 (pl) | 1998-05-11 | 2007-06-29 | Novo Nordisk As | Związki o właściwościach uwalniania hormonu wzrostu, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
| EP1085869A4 (en) | 1998-06-11 | 2001-10-04 | Merck & Co Inc | SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS |
| US6294534B1 (en) * | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO2000074679A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| AU4929601A (en) | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Substituted piperidines as melanocortin receptor agonists |
| AU4928101A (en) | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Spiropiperidine derivatives as melanocortin receptor agonists |
| JP2001316378A (ja) * | 2000-04-28 | 2001-11-13 | Takeda Chem Ind Ltd | ベンズアミド誘導体およびその用途 |
| AU2001264977B2 (en) | 2000-05-30 | 2005-04-14 | Merck & Co., Inc. | Melanocortin receptor agonists |
| KR20030017571A (ko) | 2000-06-28 | 2003-03-03 | 화이자 프로덕츠 인크. | 멜라노코르틴 수용체 리간드 |
| CA2419310A1 (en) | 2000-08-23 | 2002-02-28 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| US7169777B2 (en) * | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
| JP2004523530A (ja) | 2001-01-23 | 2004-08-05 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
| US7157463B2 (en) | 2001-01-23 | 2007-01-02 | Eli Lilly And Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| EP1372653B1 (en) | 2001-02-28 | 2006-10-04 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| HUP0303376A3 (en) | 2001-02-28 | 2007-08-28 | Merck & Co Inc | Acylated piperidine derivatives as melanocortin-4 receptor agonists, and pharmaceutical compositions containing them and use thereof |
| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| WO2003031410A1 (en) | 2001-10-09 | 2003-04-17 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| ITTO20040423A1 (it) * | 2004-06-23 | 2004-09-23 | Thermoplay Spa | Piastra di distribuzione per uno stampo per lo stampaggio ad iniezione di materiali plastici. |
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- 2002-04-24 AU AU2002254744A patent/AU2002254744B2/en not_active Ceased
- 2002-04-24 KR KR1020037013997A patent/KR100662309B1/ko not_active IP Right Cessation
- 2002-04-24 CA CA002444599A patent/CA2444599A1/en not_active Abandoned
- 2002-04-24 IL IL15796902A patent/IL157969A0/xx unknown
- 2002-04-24 KR KR1020067006130A patent/KR20060029706A/ko not_active Application Discontinuation
- 2002-04-24 WO PCT/US2002/013340 patent/WO2002085925A2/en active Application Filing
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- 2002-04-24 SK SK1322-2003A patent/SK13222003A3/sk unknown
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- 2002-04-24 CZ CZ20032806A patent/CZ20032806A3/cs unknown
- 2002-04-24 EP EP02723988A patent/EP1390361A4/en not_active Withdrawn
- 2002-04-24 RU RU2003134019/04A patent/RU2277535C2/ru not_active IP Right Cessation
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| US20040224985A1 (en) | 2004-11-11 |
| MA27016A1 (fr) | 2004-12-20 |
| SK13222003A3 (sk) | 2004-04-06 |
| HUP0500870A3 (en) | 2008-03-28 |
| KR100662309B1 (ko) | 2007-02-28 |
| EP1390361A4 (en) | 2005-10-05 |
| KR20040007509A (ko) | 2004-01-24 |
| KR20060029706A (ko) | 2006-04-06 |
| CZ20032806A3 (cs) | 2004-02-18 |
| NZ528262A (en) | 2007-04-27 |
| US20060106059A1 (en) | 2006-05-18 |
| AU2002254744B2 (en) | 2006-02-23 |
| HUP0500870A2 (hu) | 2005-12-28 |
| PE20021087A1 (es) | 2003-02-20 |
| JP2005503342A (ja) | 2005-02-03 |
| EP1390361A2 (en) | 2004-02-25 |
| PL373503A1 (en) | 2005-09-05 |
| BR0209193A (pt) | 2005-10-25 |
| NO20034774L (no) | 2003-12-29 |
| MXPA03009791A (es) | 2004-01-29 |
| RU2277535C2 (ru) | 2006-06-10 |
| IL157969A0 (en) | 2004-03-28 |
| RU2003134019A (ru) | 2005-06-10 |
| WO2002085925A3 (en) | 2003-12-11 |
| US7087759B2 (en) | 2006-08-08 |
| US20030109556A1 (en) | 2003-06-12 |
| US6911447B2 (en) | 2005-06-28 |
| NO20034774D0 (no) | 2003-10-24 |
| AR035863A1 (es) | 2004-07-21 |
| WO2002085925A2 (en) | 2002-10-31 |
| CN1543461A (zh) | 2004-11-03 |
| CA2444599A1 (en) | 2002-10-31 |
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