ZA200302085B - 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents. - Google Patents
3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents. Download PDFInfo
- Publication number
- ZA200302085B ZA200302085B ZA200302085A ZA200302085A ZA200302085B ZA 200302085 B ZA200302085 B ZA 200302085B ZA 200302085 A ZA200302085 A ZA 200302085A ZA 200302085 A ZA200302085 A ZA 200302085A ZA 200302085 B ZA200302085 B ZA 200302085B
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- South Africa
- Prior art keywords
- compound
- formula
- hydrogen
- set forth
- pharmaceutically acceptable
- Prior art date
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- 239000003242 anti bacterial agent Substances 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 36
- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 11
- -1 2,5-dihydroxy-4-oxo- 1,4-dihydro-pyridin-2-yl-carbonyl Chemical group 0.000 claims description 10
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- NSRVGDULUQOEBX-UHFFFAOYSA-N 3-amino-2-oxoazetidine-1-sulfonic acid Chemical compound NC1CN(S(O)(=O)=O)C1=O NSRVGDULUQOEBX-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23261700P | 2000-09-14 | 2000-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200302085B true ZA200302085B (en) | 2004-03-15 |
Family
ID=22873854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200302085A ZA200302085B (en) | 2000-09-14 | 2001-09-14 | 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6916803B2 (pt) |
| EP (1) | EP1322648B1 (pt) |
| JP (1) | JP2004509122A (pt) |
| KR (1) | KR100854810B1 (pt) |
| CN (1) | CN1189469C (pt) |
| AT (1) | ATE298750T1 (pt) |
| AU (2) | AU1261402A (pt) |
| BR (1) | BR0113861A (pt) |
| CA (1) | CA2422375C (pt) |
| CZ (1) | CZ304586B6 (pt) |
| DE (1) | DE60111757T2 (pt) |
| DK (1) | DK1322648T3 (pt) |
| ES (1) | ES2244666T3 (pt) |
| HK (1) | HK1054377A1 (pt) |
| HU (1) | HUP0301025A3 (pt) |
| IL (2) | IL154593A0 (pt) |
| NO (1) | NO324946B1 (pt) |
| NZ (1) | NZ524292A (pt) |
| PL (1) | PL218196B1 (pt) |
| PT (1) | PT1322648E (pt) |
| SK (1) | SK2462003A3 (pt) |
| WO (1) | WO2002022613A1 (pt) |
| ZA (1) | ZA200302085B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012233003B2 (en) * | 2005-12-07 | 2014-12-18 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| DK2484680T3 (da) | 2005-12-07 | 2013-09-08 | Basilea Pharmaceutica Ag | Nyttige kombinationer af monolactam-antibiotika med beta-lactamase-inhibitorer |
| KR101320718B1 (ko) * | 2007-03-23 | 2013-10-21 | 바실리어 파마슈티카 아게 | 세균 감염 치료용 조합 약제 |
| US20110046101A1 (en) * | 2008-03-17 | 2011-02-24 | Dmitrienko Gary I | Bate-lactamase inhibitors |
| ES2691468T3 (es) | 2010-08-10 | 2018-11-27 | Rempex Pharmaceuticals, Inc. | Derivados de éster del ácido borónico cíclicos y usos terapéuticos de los mismos |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| CN102757405B (zh) * | 2012-07-25 | 2014-04-16 | 山东理工大学 | 含噻二唑的香兰素衍生物、其制备方法及其用途 |
| MX2015008628A (es) | 2013-01-04 | 2015-09-23 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y usos terapeuticos de los mismos. |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP2941247A4 (en) | 2013-01-04 | 2017-02-08 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| LT3604316T (lt) | 2014-05-05 | 2024-02-26 | Melinta Therapeutics, Inc. | Boronato druskų sintezė |
| KR20170007448A (ko) | 2014-05-19 | 2017-01-18 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| EP3164406A4 (en) | 2014-07-01 | 2018-04-04 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| EP3233869B1 (en) | 2014-12-19 | 2019-09-25 | Rempex Pharmaceuticals, Inc. | Apparatus and continuous flow process for production of boronic acid derivatives |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| KR102403296B1 (ko) | 2016-06-30 | 2022-05-27 | 큐펙스 바이오파마 인코포레이티드 | 보론산 유도체 및 이의 치료적 용도 |
| CN107641119B (zh) * | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| CA3047634A1 (en) | 2016-12-21 | 2018-04-12 | Aicuris Gmbh & Co. Kg | Combination therapy with amidine substituted .beta.-lactam compounds and .beta.-lactamase inhibitors for infections with antibiotic resistant bacterial strains |
| BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
| CN111511737B (zh) | 2018-01-29 | 2022-10-18 | 南京明德新药研发有限公司 | 用于治疗细菌感染的单环β-内酰胺化合物 |
| JP7329260B2 (ja) | 2018-04-20 | 2023-08-18 | キューペックス バイオファーマ， インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| JP7179185B2 (ja) | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β－ラクタム化合物の使用 |
| SI25892A (sl) * | 2019-09-05 | 2021-03-31 | Gorenje Gospodinjski Aparati, D.O.O. | Pralni stroj, ki se polni s sprednje strani, z električnim svetlobnim telesom |
| WO2021048613A2 (en) * | 2019-09-11 | 2021-03-18 | Tennor Therapeutics Limited | Penam derivatives for treating bacterial infections |
| EP4046998B1 (en) | 2019-11-22 | 2024-02-28 | Suzhou Erye Pharmaceutical Co., Ltd. | Sulfonylurea ring substituted monocyclic beta-lactam antibiotics |
| WO2021121387A1 (zh) | 2019-12-19 | 2021-06-24 | 南京明德新药研发有限公司 | 化合物在制药中的应用 |
| CN113754651B (zh) * | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
| JP2024532211A (ja) * | 2021-08-20 | 2024-09-05 | ユニバーシティ・オブ・ノートル・ダム・デュ・ラック | 単環式β－ラクタムとシデロフォア模倣体との結合体 |
| CN115304594B (zh) | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4632985A (en) | 1985-06-03 | 1986-12-30 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
| GB8810396D0 (en) | 1988-05-03 | 1988-06-08 | Glaxo Group Ltd | Chemical process |
| US5112968A (en) * | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| US5888998A (en) * | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
| US5994340A (en) * | 1997-08-29 | 1999-11-30 | Synphar Laboratories, Inc. | Azetidinone derivatives as β-lactamase inhibitors |
-
2001
- 2001-09-14 BR BR0113861-8A patent/BR0113861A/pt active Search and Examination
- 2001-09-14 IL IL15459301A patent/IL154593A0/xx active IP Right Grant
- 2001-09-14 SK SK246-2003A patent/SK2462003A3/sk unknown
- 2001-09-14 AT AT01980829T patent/ATE298750T1/de active
- 2001-09-14 CZ CZ2003-606A patent/CZ304586B6/cs not_active IP Right Cessation
- 2001-09-14 DE DE60111757T patent/DE60111757T2/de not_active Expired - Lifetime
- 2001-09-14 NZ NZ524292A patent/NZ524292A/en unknown
- 2001-09-14 KR KR1020037003718A patent/KR100854810B1/ko not_active IP Right Cessation
- 2001-09-14 ZA ZA200302085A patent/ZA200302085B/en unknown
- 2001-09-14 WO PCT/IB2001/002115 patent/WO2002022613A1/en active IP Right Grant
- 2001-09-14 HU HU0301025A patent/HUP0301025A3/hu unknown
- 2001-09-14 CN CNB018157319A patent/CN1189469C/zh not_active Expired - Fee Related
- 2001-09-14 JP JP2002526866A patent/JP2004509122A/ja active Pending
- 2001-09-14 AU AU1261402A patent/AU1261402A/xx active Pending
- 2001-09-14 DK DK01980829T patent/DK1322648T3/da active
- 2001-09-14 CA CA2422375A patent/CA2422375C/en not_active Expired - Fee Related
- 2001-09-14 US US10/363,222 patent/US6916803B2/en not_active Expired - Fee Related
- 2001-09-14 PT PT01980829T patent/PT1322648E/pt unknown
- 2001-09-14 PL PL360537A patent/PL218196B1/pl unknown
- 2001-09-14 AU AU2002212614A patent/AU2002212614B2/en not_active Ceased
- 2001-09-14 ES ES01980829T patent/ES2244666T3/es not_active Expired - Lifetime
- 2001-09-14 EP EP01980829A patent/EP1322648B1/en not_active Expired - Lifetime
-
2003
- 2003-02-24 IL IL154593A patent/IL154593A/en not_active IP Right Cessation
- 2003-03-13 NO NO20031162A patent/NO324946B1/no not_active IP Right Cessation
- 2003-09-03 HK HK03106287A patent/HK1054377A1/xx not_active IP Right Cessation
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