ZA200209811B - Local anesthetic methods and kits. - Google Patents
Local anesthetic methods and kits. Download PDFInfo
- Publication number
- ZA200209811B ZA200209811B ZA200209811A ZA200209811A ZA200209811B ZA 200209811 B ZA200209811 B ZA 200209811B ZA 200209811 A ZA200209811 A ZA 200209811A ZA 200209811 A ZA200209811 A ZA 200209811A ZA 200209811 B ZA200209811 B ZA 200209811B
- Authority
- ZA
- South Africa
- Prior art keywords
- adrenergic receptor
- unit dose
- alpha adrenergic
- receptor antagonist
- phentolamine
- Prior art date
Links
- 239000003589 local anesthetic agent Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 36
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 claims abstract description 53
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 claims abstract description 53
- 239000000674 adrenergic antagonist Substances 0.000 claims abstract description 52
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims abstract description 38
- PPWLAQVKIFDULF-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine Chemical compound N1C2=NC=CC=C2C=C1C1=CC=CC=C1 PPWLAQVKIFDULF-UHFFFAOYSA-N 0.000 claims description 43
- 229960003056 phentolamine mesylate Drugs 0.000 claims description 43
- 239000003193 general anesthetic agent Substances 0.000 claims description 28
- 210000001519 tissue Anatomy 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 27
- 241000124008 Mammalia Species 0.000 claims description 25
- 239000007924 injection Substances 0.000 claims description 24
- 238000002347 injection Methods 0.000 claims description 24
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- 239000003814 drug Substances 0.000 claims description 19
- 229960002773 hyaluronidase Drugs 0.000 claims description 19
- 230000003444 anaesthetic effect Effects 0.000 claims description 18
- 229960001999 phentolamine Drugs 0.000 claims description 18
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
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- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 12
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- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 9
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims description 9
- BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 claims description 8
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- GEFQWZLICWMTKF-CDUCUWFYSA-N (-)-alpha-Methylnoradrenaline Chemical group C[C@H](N)[C@H](O)C1=CC=C(O)C(O)=C1 GEFQWZLICWMTKF-CDUCUWFYSA-N 0.000 claims description 7
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- BLGXFZZNTVWLAY-CCZXDCJGSA-N Yohimbine Natural products C1=CC=C2C(CCN3C[C@@H]4CC[C@@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-CCZXDCJGSA-N 0.000 claims description 4
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- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 claims description 4
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- 239000008188 pellet Substances 0.000 claims description 3
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- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 2
- 229960001807 prilocaine Drugs 0.000 claims description 2
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- 230000000699 topical effect Effects 0.000 claims 6
- 229960001632 labetalol Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000002690 local anesthesia Methods 0.000 abstract description 42
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- 230000000694 effects Effects 0.000 description 22
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
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- 239000011780 sodium chloride Substances 0.000 description 11
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- 238000009792 diffusion process Methods 0.000 description 4
- 238000002692 epidural anesthesia Methods 0.000 description 4
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- 229960002660 mepivacaine hydrochloride Drugs 0.000 description 1
- RETIMRUQNCDCQB-UHFFFAOYSA-N mepivacaine hydrochloride Chemical compound Cl.CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C RETIMRUQNCDCQB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20380000P | 2000-05-12 | 2000-05-12 | |
US23585500P | 2000-09-27 | 2000-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200209811B true ZA200209811B (en) | 2003-12-03 |
Family
ID=26898913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200209811A ZA200209811B (en) | 2000-05-12 | 2002-12-03 | Local anesthetic methods and kits. |
Country Status (14)
Country | Link |
---|---|
US (8) | US6432401B2 (da) |
EP (2) | EP1280531B1 (da) |
JP (2) | JP2003532678A (da) |
AT (1) | ATE352300T1 (da) |
AU (3) | AU2001259848B2 (da) |
CA (1) | CA2408417C (da) |
CY (1) | CY1107617T1 (da) |
DE (1) | DE60126265T2 (da) |
DK (1) | DK1280531T3 (da) |
ES (1) | ES2281418T3 (da) |
NZ (1) | NZ522930A (da) |
PT (1) | PT1280531E (da) |
WO (1) | WO2001085171A1 (da) |
ZA (1) | ZA200209811B (da) |
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2001
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- 2001-05-11 WO PCT/US2001/040711 patent/WO2001085171A1/en active IP Right Grant
- 2001-05-11 US US09/852,751 patent/US6432401B2/en not_active Expired - Lifetime
- 2001-05-11 AU AU2001259848A patent/AU2001259848B2/en not_active Ceased
- 2001-05-11 ES ES01933419T patent/ES2281418T3/es not_active Expired - Lifetime
- 2001-05-11 AT AT01933419T patent/ATE352300T1/de active
- 2001-05-11 PT PT01933419T patent/PT1280531E/pt unknown
- 2001-05-11 EP EP01933419A patent/EP1280531B1/en not_active Expired - Lifetime
- 2001-05-11 DE DE60126265T patent/DE60126265T2/de not_active Expired - Lifetime
- 2001-05-11 AU AU5984801A patent/AU5984801A/xx active Pending
- 2001-05-11 JP JP2001581825A patent/JP2003532678A/ja active Pending
- 2001-05-11 EP EP06024671.7A patent/EP1762236B1/en not_active Expired - Lifetime
- 2001-05-11 NZ NZ522930A patent/NZ522930A/en not_active IP Right Cessation
- 2001-05-11 DK DK01933419T patent/DK1280531T3/da active
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2002
- 2002-05-28 US US10/155,020 patent/US6872390B2/en not_active Expired - Lifetime
- 2002-05-28 US US10/155,171 patent/US6764678B2/en not_active Expired - Lifetime
- 2002-12-03 ZA ZA200209811A patent/ZA200209811B/en unknown
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2003
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2004
- 2004-04-05 US US10/816,900 patent/US20040198816A1/en not_active Abandoned
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2005
- 2005-03-17 US US11/081,641 patent/US20050165098A1/en not_active Abandoned
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- 2005-09-26 AU AU2005211689A patent/AU2005211689B2/en not_active Ceased
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2006
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2007
- 2007-04-19 CY CY20071100532T patent/CY1107617T1/el unknown
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- 2008-11-21 US US12/275,556 patent/US20090076023A1/en not_active Abandoned
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