ZA200207968B - Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. - Google Patents
Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. Download PDFInfo
- Publication number
- ZA200207968B ZA200207968B ZA200207968A ZA200207968A ZA200207968B ZA 200207968 B ZA200207968 B ZA 200207968B ZA 200207968 A ZA200207968 A ZA 200207968A ZA 200207968 A ZA200207968 A ZA 200207968A ZA 200207968 B ZA200207968 B ZA 200207968B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- composition
- methyl
- benzamide
- substance
- Prior art date
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- 208000002193 Pain Diseases 0.000 title claims description 13
- 230000036407 pain Effects 0.000 title claims description 11
- VCTJCAQVWZSOSM-UHFFFAOYSA-N 4-hydroxy-2-methyl-3-phenyl-n-piperidin-4-ylidenebenzamide Chemical class CC1=C(C(=O)N=C2CCNCC2)C=CC(O)=C1C1=CC=CC=C1 VCTJCAQVWZSOSM-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 36
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- -1 NO» Chemical group 0.000 claims description 13
- 230000002829 reductive effect Effects 0.000 claims description 11
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- 238000002560 therapeutic procedure Methods 0.000 claims description 10
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- 150000003839 salts Chemical class 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
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- 238000006243 chemical reaction Methods 0.000 claims description 4
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- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
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- 229960004127 naloxone Drugs 0.000 description 1
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- RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical compound CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
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- 239000010452 phosphate Substances 0.000 description 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 238000002600 positron emission tomography Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 235000011181 potassium carbonates Nutrition 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
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- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001207A SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207968B true ZA200207968B (en) | 2004-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207968A ZA200207968B (en) | 2000-04-04 | 2002-10-03 | Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6756387B2 (de) |
| EP (1) | EP1282616B1 (de) |
| JP (1) | JP2003529596A (de) |
| KR (1) | KR20020084285A (de) |
| CN (1) | CN1185228C (de) |
| AR (1) | AR027983A1 (de) |
| AT (1) | ATE269324T1 (de) |
| AU (1) | AU2001244981A1 (de) |
| BR (1) | BR0109816A (de) |
| CA (1) | CA2404386A1 (de) |
| CZ (1) | CZ20023289A3 (de) |
| DE (1) | DE60103889T2 (de) |
| DK (1) | DK1282616T3 (de) |
| EE (1) | EE200200571A (de) |
| ES (1) | ES2220748T3 (de) |
| HK (1) | HK1051690A1 (de) |
| HU (1) | HUP0300427A2 (de) |
| IL (1) | IL151890A0 (de) |
| IS (1) | IS6575A (de) |
| MX (1) | MXPA02009757A (de) |
| NO (1) | NO20024775L (de) |
| NZ (1) | NZ522142A (de) |
| PL (1) | PL357780A1 (de) |
| PT (1) | PT1282616E (de) |
| RU (1) | RU2002125495A (de) |
| SE (1) | SE0001207D0 (de) |
| SK (1) | SK14232002A3 (de) |
| WO (1) | WO2001074804A1 (de) |
| ZA (1) | ZA200207968B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE0101768D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101769D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) * | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| AU2003214800A1 (en) | 2002-01-02 | 2003-07-24 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203301D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301443D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| MXPA05012117A (es) * | 2003-05-16 | 2006-02-08 | Astrazeneca Ab | Derivados de diarilmetiliden piperidina, preparaciones de los mismos y usos de los mismos. |
| EP1644373A1 (de) * | 2003-06-27 | 2006-04-12 | Janssen Pharmaceutica N.V. | Tricyclische delta-opioid-modulatoren |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0402485D0 (sv) | 2004-10-13 | 2004-10-13 | Astrazeneca Ab | Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| JP4754068B2 (ja) * | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
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2000
- 2000-04-04 SE SE0001207A patent/SE0001207D0/xx unknown
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2001
- 2001-03-28 AR ARP010101477A patent/AR027983A1/es not_active Application Discontinuation
- 2001-03-30 BR BR0109816-0A patent/BR0109816A/pt not_active IP Right Cessation
- 2001-03-30 CA CA002404386A patent/CA2404386A1/en not_active Abandoned
- 2001-03-30 CN CNB018105939A patent/CN1185228C/zh not_active Expired - Fee Related
- 2001-03-30 JP JP2001572494A patent/JP2003529596A/ja active Pending
- 2001-03-30 CZ CZ20023289A patent/CZ20023289A3/cs unknown
- 2001-03-30 KR KR1020027013207A patent/KR20020084285A/ko not_active Application Discontinuation
- 2001-03-30 PL PL01357780A patent/PL357780A1/xx not_active Application Discontinuation
- 2001-03-30 AT AT01918113T patent/ATE269324T1/de not_active IP Right Cessation
- 2001-03-30 HU HU0300427A patent/HUP0300427A2/hu unknown
- 2001-03-30 SK SK1423-2002A patent/SK14232002A3/sk not_active Application Discontinuation
- 2001-03-30 ES ES01918113T patent/ES2220748T3/es not_active Expired - Lifetime
- 2001-03-30 IL IL15189001A patent/IL151890A0/xx unknown
- 2001-03-30 US US10/240,038 patent/US6756387B2/en not_active Expired - Fee Related
- 2001-03-30 RU RU2002125495/04A patent/RU2002125495A/ru not_active Application Discontinuation
- 2001-03-30 AU AU2001244981A patent/AU2001244981A1/en not_active Abandoned
- 2001-03-30 EE EEP200200571A patent/EE200200571A/xx unknown
- 2001-03-30 MX MXPA02009757A patent/MXPA02009757A/es unknown
- 2001-03-30 DE DE60103889T patent/DE60103889T2/de not_active Expired - Fee Related
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- 2001-03-30 WO PCT/SE2001/000707 patent/WO2001074804A1/en active IP Right Grant
- 2001-03-30 NZ NZ522142A patent/NZ522142A/en unknown
- 2001-03-30 EP EP01918113A patent/EP1282616B1/de not_active Expired - Lifetime
- 2001-03-30 PT PT01918113T patent/PT1282616E/pt unknown
-
2002
- 2002-09-30 IS IS6575A patent/IS6575A/is unknown
- 2002-10-03 NO NO20024775A patent/NO20024775L/no not_active Application Discontinuation
- 2002-10-03 ZA ZA200207968A patent/ZA200207968B/en unknown
-
2003
- 2003-06-05 HK HK03103988A patent/HK1051690A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL357780A1 (en) | 2004-07-26 |
| RU2002125495A (ru) | 2004-04-10 |
| SE0001207D0 (sv) | 2000-04-04 |
| US6756387B2 (en) | 2004-06-29 |
| NO20024775D0 (no) | 2002-10-03 |
| EE200200571A (et) | 2004-04-15 |
| CN1432009A (zh) | 2003-07-23 |
| ES2220748T3 (es) | 2004-12-16 |
| AR027983A1 (es) | 2003-04-23 |
| AU2001244981A1 (en) | 2001-10-15 |
| HK1051690A1 (en) | 2003-08-15 |
| KR20020084285A (ko) | 2002-11-04 |
| BR0109816A (pt) | 2003-01-21 |
| WO2001074804A1 (en) | 2001-10-11 |
| SK14232002A3 (sk) | 2003-06-03 |
| NO20024775L (no) | 2002-12-03 |
| NZ522142A (en) | 2004-06-25 |
| ATE269324T1 (de) | 2004-07-15 |
| DK1282616T3 (da) | 2004-09-20 |
| JP2003529596A (ja) | 2003-10-07 |
| EP1282616B1 (de) | 2004-06-16 |
| CZ20023289A3 (cs) | 2003-03-12 |
| HUP0300427A2 (hu) | 2003-06-28 |
| EP1282616A1 (de) | 2003-02-12 |
| MXPA02009757A (es) | 2003-05-27 |
| DE60103889D1 (de) | 2004-07-22 |
| IS6575A (is) | 2002-09-30 |
| PT1282616E (pt) | 2004-10-29 |
| US20030187022A1 (en) | 2003-10-02 |
| CA2404386A1 (en) | 2001-10-11 |
| IL151890A0 (en) | 2003-04-10 |
| DE60103889T2 (de) | 2005-08-25 |
| CN1185228C (zh) | 2005-01-19 |
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