ZA200204429B - New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. - Google Patents
New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. Download PDFInfo
- Publication number
- ZA200204429B ZA200204429B ZA200204429A ZA200204429A ZA200204429B ZA 200204429 B ZA200204429 B ZA 200204429B ZA 200204429 A ZA200204429 A ZA 200204429A ZA 200204429 A ZA200204429 A ZA 200204429A ZA 200204429 B ZA200204429 B ZA 200204429B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzoxazin
- piperidin
- nitro
- benzamide
- apci
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title description 4
- 239000002464 receptor antagonist Substances 0.000 title description 4
- 229940044551 receptor antagonist Drugs 0.000 title description 4
- 208000024172 Cardiovascular disease Diseases 0.000 title description 3
- 102100037602 P2X purinoceptor 7 Human genes 0.000 title description 2
- 101710189965 P2X purinoceptor 7 Proteins 0.000 title description 2
- 208000026278 immune system disease Diseases 0.000 title description 2
- 208000027866 inflammatory disease Diseases 0.000 title description 2
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- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904652A SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Novel Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200204429B true ZA200204429B (en) | 2003-09-03 |
Family
ID=20418188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200204429A ZA200204429B (en) | 1999-12-17 | 2002-06-03 | New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6812226B2 (no) |
| EP (1) | EP1242396B1 (no) |
| JP (1) | JP2003516978A (no) |
| KR (1) | KR20020067554A (no) |
| CN (1) | CN1304382C (no) |
| AT (1) | ATE250590T1 (no) |
| AU (1) | AU775741B2 (no) |
| BR (1) | BR0016396A (no) |
| CA (1) | CA2392894A1 (no) |
| DE (1) | DE60005560T2 (no) |
| IL (1) | IL150085A0 (no) |
| MX (1) | MXPA02005788A (no) |
| NO (1) | NO323538B1 (no) |
| SE (1) | SE9904652D0 (no) |
| WO (1) | WO2001044213A1 (no) |
| ZA (1) | ZA200204429B (no) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| MXPA03009602A (es) * | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
| DK1975164T3 (da) | 2001-04-18 | 2010-05-25 | Euro Celtique Sa | Octahydrobenzimidazolon-forbindelser som analgetika |
| PT1379246E (pt) * | 2001-04-18 | 2009-01-14 | Euro Celtique Sa | Análogos de nociceptina |
| DE60229736D1 (de) | 2001-04-18 | 2008-12-18 | Euro Celtique Sa | Spiroinden- und spiroindan-verbindungen |
| AU2002311833B2 (en) | 2001-04-18 | 2005-04-28 | Euro-Celtique S.A. | Spiropyrazole compounds |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) * | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| EP1474395B1 (en) * | 2002-02-12 | 2007-10-17 | Smithkline Beecham Corporation | Nicotinamide derivates useful as p38 inhibitors |
| ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| DE602004007184T2 (de) | 2003-04-17 | 2008-02-28 | Affectis Pharmaceuticals Ag | Mittel und Verfahren zur Diagnose und Behandlung affektiver Störungen |
| EP1626962B1 (en) * | 2003-05-12 | 2007-02-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
| GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| WO2005095359A1 (en) * | 2004-03-05 | 2005-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| US20080287467A1 (en) * | 2004-05-06 | 2008-11-20 | Gen Tamura | Therapeutic Agent for Respiratory Diseases |
| MXPA06014022A (es) * | 2004-06-29 | 2007-02-08 | Pfizer Prod Inc | Prcedimientos para preparar inhibidores de p2x7. |
| CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CA2580787A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| EP2269610A3 (en) * | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| WO2006136791A1 (en) * | 2005-06-21 | 2006-12-28 | Astrazeneca Ab | Polymorphisms and haplotypes in p2x7 gene and their use in determining susceptibility for atherosclerosis-mediated diseases |
| WO2007025366A1 (en) * | 2005-08-29 | 2007-03-08 | Irma Bernatchez-Lemaire | Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents |
| ES2601178T3 (es) * | 2005-09-01 | 2017-02-14 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P3X2/3 |
| WO2007025901A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| CN101296907B (zh) * | 2005-09-01 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类 |
| AU2006296369B2 (en) * | 2005-09-30 | 2012-12-20 | Glaxo Group Limited | Compounds which have activity at M1 receptor and their uses in medicine |
| JP5209479B2 (ja) * | 2005-09-30 | 2013-06-12 | グラクソ グループ リミテッド | Ｍ１受容体にて活性を有するベンゾイミダゾロン類 |
| ES2391107T3 (es) * | 2005-09-30 | 2012-11-21 | Glaxo Group Limited | Compuestos que tienen actividad en el receptor M1 y sus usos en medicina |
| FR2892722B1 (fr) * | 2005-11-02 | 2008-08-15 | Clinigenetics Sa | Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires |
| US20070249666A1 (en) * | 2006-03-31 | 2007-10-25 | Bratcher Natalie A | P2X7 Antagonists to Treat Affective Disorders |
| TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| EP1878721A1 (en) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
| WO2008060568A2 (en) * | 2006-11-15 | 2008-05-22 | Neurogen Corporation | Amide-substituted aryl piperidines |
| EP2124562B1 (en) * | 2007-03-09 | 2016-04-20 | Second Genome, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| PE20091225A1 (es) * | 2007-03-22 | 2009-09-16 | Astrazeneca Ab | Derivados de quinolina como antagonistas del receptor p2x7 |
| US7932879B2 (en) * | 2007-05-08 | 2011-04-26 | Sony Ericsson Mobile Communications Ab | Controlling electroluminescent panels in response to cumulative utilization |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| BRPI0910034B1 (pt) | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
| US20090275574A1 (en) * | 2008-05-05 | 2009-11-05 | Astrazeneca Ab | Novel compounds-300 |
| EP2942346B1 (en) * | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
| EP2243772B1 (en) | 2009-04-14 | 2012-01-18 | Affectis Pharmaceuticals AG | Novel P2X7R antagonists and their use |
| CN102471284A (zh) * | 2009-07-30 | 2012-05-23 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x7调节剂的二氢嘧啶酮酰胺 |
| EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
| WO2011072012A2 (en) | 2009-12-08 | 2011-06-16 | Vanderbilt University | Improved methods and compositions for vein harvest and autografting |
| AU2011252351A1 (en) | 2010-05-14 | 2012-10-11 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of P2X7R antagonists |
| AU2011293612B2 (en) | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2013012848A1 (en) * | 2011-07-18 | 2013-01-24 | Merck Patent Gmbh | Benzamides |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| GB201508864D0 (en) * | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| CN109136361A (zh) * | 2018-08-01 | 2019-01-04 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | P2x7受体在诊断和治疗类风湿关节炎方面的应用 |
Family Cites Families (4)
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| IL106507A (en) * | 1992-08-07 | 1997-11-20 | Merck & Co Inc | Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type |
| CA2200468A1 (en) * | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Muscarine antagonists |
| US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
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1999
- 1999-12-17 SE SE9904652A patent/SE9904652D0/xx unknown
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2000
- 2000-12-12 CA CA002392894A patent/CA2392894A1/en not_active Abandoned
- 2000-12-12 JP JP2001544703A patent/JP2003516978A/ja active Pending
- 2000-12-12 KR KR1020027007697A patent/KR20020067554A/ko active IP Right Grant
- 2000-12-12 AU AU22443/01A patent/AU775741B2/en not_active Ceased
- 2000-12-12 CN CNB008189234A patent/CN1304382C/zh not_active Expired - Fee Related
- 2000-12-12 BR BR0016396-1A patent/BR0016396A/pt not_active IP Right Cessation
- 2000-12-12 DE DE60005560T patent/DE60005560T2/de not_active Expired - Lifetime
- 2000-12-12 EP EP00986154A patent/EP1242396B1/en not_active Expired - Lifetime
- 2000-12-12 AT AT00986154T patent/ATE250590T1/de not_active IP Right Cessation
- 2000-12-12 US US10/149,760 patent/US6812226B2/en not_active Expired - Fee Related
- 2000-12-12 MX MXPA02005788A patent/MXPA02005788A/es active IP Right Grant
- 2000-12-12 IL IL15008500A patent/IL150085A0/xx unknown
- 2000-12-12 WO PCT/SE2000/002504 patent/WO2001044213A1/en active IP Right Grant
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2002
- 2002-06-03 ZA ZA200204429A patent/ZA200204429B/en unknown
- 2002-06-14 NO NO20022857A patent/NO323538B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001044213A1 (en) | 2001-06-21 |
| CN1304382C (zh) | 2007-03-14 |
| JP2003516978A (ja) | 2003-05-20 |
| NO323538B1 (no) | 2007-06-04 |
| DE60005560D1 (de) | 2003-10-30 |
| ATE250590T1 (de) | 2003-10-15 |
| US6812226B2 (en) | 2004-11-02 |
| AU775741B2 (en) | 2004-08-12 |
| KR20020067554A (ko) | 2002-08-22 |
| NO20022857L (no) | 2002-08-01 |
| US20030040513A1 (en) | 2003-02-27 |
| CA2392894A1 (en) | 2001-06-21 |
| EP1242396B1 (en) | 2003-09-24 |
| BR0016396A (pt) | 2002-08-20 |
| AU2244301A (en) | 2001-06-25 |
| EP1242396A1 (en) | 2002-09-25 |
| CN1434811A (zh) | 2003-08-06 |
| MXPA02005788A (es) | 2002-09-18 |
| SE9904652D0 (sv) | 1999-12-17 |
| DE60005560T2 (de) | 2004-07-15 |
| NO20022857D0 (no) | 2002-06-14 |
| IL150085A0 (en) | 2002-12-01 |
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