SE9904652D0 - Novel Compounds - Google Patents
Novel CompoundsInfo
- Publication number
- SE9904652D0 SE9904652D0 SE9904652A SE9904652A SE9904652D0 SE 9904652 D0 SE9904652 D0 SE 9904652D0 SE 9904652 A SE9904652 A SE 9904652A SE 9904652 A SE9904652 A SE 9904652A SE 9904652 D0 SE9904652 D0 SE 9904652D0
- Authority
- SE
- Sweden
- Prior art keywords
- novel compounds
- medicaments
- processes
- preparation
- general formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9904652A SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Novel Compounds |
IL15008500A IL150085A0 (en) | 1999-12-17 | 2000-12-12 | New-p2x7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases |
AT00986154T ATE250590T1 (de) | 1999-12-17 | 2000-12-12 | Neuartiger p2x 7 rezeptor-antagonisten zur verwendung in der behandlung von entzündlichen, immuninduzierten erkrankungen oder erkrankungen des herz-kreislauf-systems |
KR1020027007697A KR20020067554A (ko) | 1999-12-17 | 2000-12-12 | 염증성 질환, 면역성 질환 또는 심혈관계 질환 치료용신규 p2x7 수용체 길항제 |
BR0016396-1A BR0016396A (pt) | 1999-12-17 | 2000-12-12 | Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares |
JP2001544703A JP2003516978A (ja) | 1999-12-17 | 2000-12-12 | 炎症、免疫疾患または心血管疾患の治療に用いる新規なp2x7受容体アンタゴニスト |
CA002392894A CA2392894A1 (en) | 1999-12-17 | 2000-12-12 | New p2x7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases |
AU22443/01A AU775741B2 (en) | 1999-12-17 | 2000-12-12 | New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases |
CNB008189234A CN1304382C (zh) | 1999-12-17 | 2000-12-12 | 用于治疗炎性、免疫或心血管疾病的新的p2x7受体拮抗剂 |
US10/149,760 US6812226B2 (en) | 1999-12-17 | 2000-12-12 | P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease |
PCT/SE2000/002504 WO2001044213A1 (en) | 1999-12-17 | 2000-12-12 | New p2x7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases |
DE60005560T DE60005560T2 (de) | 1999-12-17 | 2000-12-12 | Neuartiger p2x 7 rezeptor-antagonisten zur verwendung in der behandlung von entzündlichen, immuninduzierten erkrankungen oder erkrankungen des herz-kreislauf-systems |
MXPA02005788A MXPA02005788A (es) | 1999-12-17 | 2000-12-12 | Antagonistas del receptor p2x7 novedosos para uso en el tratamiento de enfermedades inflamatorias, inmunes o cardiovasculares. |
EP00986154A EP1242396B1 (en) | 1999-12-17 | 2000-12-12 | New p2x 7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases |
ZA200204429A ZA200204429B (en) | 1999-12-17 | 2002-06-03 | New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. |
NO20022857A NO323538B1 (no) | 1999-12-17 | 2002-06-14 | Nye P2X7-reseptoragonister for bruk i behandling av inflammatoriske, immun- eller kardiovaskulaere sykdommer, fremgangsmate for fremstilling derav, samt farmasoytiske blandinger som inneholder slike. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9904652A SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9904652D0 true SE9904652D0 (sv) | 1999-12-17 |
Family
ID=20418188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9904652A SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Novel Compounds |
Country Status (16)
Country | Link |
---|---|
US (1) | US6812226B2 (xx) |
EP (1) | EP1242396B1 (xx) |
JP (1) | JP2003516978A (xx) |
KR (1) | KR20020067554A (xx) |
CN (1) | CN1304382C (xx) |
AT (1) | ATE250590T1 (xx) |
AU (1) | AU775741B2 (xx) |
BR (1) | BR0016396A (xx) |
CA (1) | CA2392894A1 (xx) |
DE (1) | DE60005560T2 (xx) |
IL (1) | IL150085A0 (xx) |
MX (1) | MXPA02005788A (xx) |
NO (1) | NO323538B1 (xx) |
SE (1) | SE9904652D0 (xx) |
WO (1) | WO2001044213A1 (xx) |
ZA (1) | ZA200204429B (xx) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
MXPA03009602A (es) * | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
DK1975164T3 (da) | 2001-04-18 | 2010-05-25 | Euro Celtique Sa | Octahydrobenzimidazolon-forbindelser som analgetika |
PT1379246E (pt) * | 2001-04-18 | 2009-01-14 | Euro Celtique Sa | Análogos de nociceptina |
DE60229736D1 (de) | 2001-04-18 | 2008-12-18 | Euro Celtique Sa | Spiroinden- und spiroindan-verbindungen |
AU2002311833B2 (en) | 2001-04-18 | 2005-04-28 | Euro-Celtique S.A. | Spiropyrazole compounds |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
WO2003042190A1 (en) * | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
EP1474395B1 (en) * | 2002-02-12 | 2007-10-17 | Smithkline Beecham Corporation | Nicotinamide derivates useful as p38 inhibitors |
ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
DE602004007184T2 (de) | 2003-04-17 | 2008-02-28 | Affectis Pharmaceuticals Ag | Mittel und Verfahren zur Diagnose und Behandlung affektiver Störungen |
EP1626962B1 (en) * | 2003-05-12 | 2007-02-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
WO2005095359A1 (en) * | 2004-03-05 | 2005-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
US20080287467A1 (en) * | 2004-05-06 | 2008-11-20 | Gen Tamura | Therapeutic Agent for Respiratory Diseases |
MXPA06014022A (es) * | 2004-06-29 | 2007-02-08 | Pfizer Prod Inc | Prcedimientos para preparar inhibidores de p2x7. |
CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
CA2580787A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
EP2269610A3 (en) * | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
WO2006136791A1 (en) * | 2005-06-21 | 2006-12-28 | Astrazeneca Ab | Polymorphisms and haplotypes in p2x7 gene and their use in determining susceptibility for atherosclerosis-mediated diseases |
WO2007025366A1 (en) * | 2005-08-29 | 2007-03-08 | Irma Bernatchez-Lemaire | Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents |
ES2601178T3 (es) * | 2005-09-01 | 2017-02-14 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P3X2/3 |
WO2007025901A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
CN101296907B (zh) * | 2005-09-01 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类 |
AU2006296369B2 (en) * | 2005-09-30 | 2012-12-20 | Glaxo Group Limited | Compounds which have activity at M1 receptor and their uses in medicine |
JP5209479B2 (ja) * | 2005-09-30 | 2013-06-12 | グラクソ グループ リミテッド | M1受容体にて活性を有するベンゾイミダゾロン類 |
ES2391107T3 (es) * | 2005-09-30 | 2012-11-21 | Glaxo Group Limited | Compuestos que tienen actividad en el receptor M1 y sus usos en medicina |
FR2892722B1 (fr) * | 2005-11-02 | 2008-08-15 | Clinigenetics Sa | Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires |
US20070249666A1 (en) * | 2006-03-31 | 2007-10-25 | Bratcher Natalie A | P2X7 Antagonists to Treat Affective Disorders |
TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
EP1878721A1 (en) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
WO2008060568A2 (en) * | 2006-11-15 | 2008-05-22 | Neurogen Corporation | Amide-substituted aryl piperidines |
EP2124562B1 (en) * | 2007-03-09 | 2016-04-20 | Second Genome, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
PE20091225A1 (es) * | 2007-03-22 | 2009-09-16 | Astrazeneca Ab | Derivados de quinolina como antagonistas del receptor p2x7 |
US7932879B2 (en) * | 2007-05-08 | 2011-04-26 | Sony Ericsson Mobile Communications Ab | Controlling electroluminescent panels in response to cumulative utilization |
US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
BRPI0910034B1 (pt) | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
US20090275574A1 (en) * | 2008-05-05 | 2009-11-05 | Astrazeneca Ab | Novel compounds-300 |
EP2942346B1 (en) * | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
EP2243772B1 (en) | 2009-04-14 | 2012-01-18 | Affectis Pharmaceuticals AG | Novel P2X7R antagonists and their use |
CN102471284A (zh) * | 2009-07-30 | 2012-05-23 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x7调节剂的二氢嘧啶酮酰胺 |
EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
WO2011072012A2 (en) | 2009-12-08 | 2011-06-16 | Vanderbilt University | Improved methods and compositions for vein harvest and autografting |
AU2011252351A1 (en) | 2010-05-14 | 2012-10-11 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of P2X7R antagonists |
AU2011293612B2 (en) | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2013012848A1 (en) * | 2011-07-18 | 2013-01-24 | Merck Patent Gmbh | Benzamides |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
GB201508864D0 (en) * | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
CN109136361A (zh) * | 2018-08-01 | 2019-01-04 | 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) | P2x7受体在诊断和治疗类风湿关节炎方面的应用 |
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IL106507A (en) * | 1992-08-07 | 1997-11-20 | Merck & Co Inc | Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type |
CA2200468A1 (en) * | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Muscarine antagonists |
US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
-
1999
- 1999-12-17 SE SE9904652A patent/SE9904652D0/xx unknown
-
2000
- 2000-12-12 CA CA002392894A patent/CA2392894A1/en not_active Abandoned
- 2000-12-12 JP JP2001544703A patent/JP2003516978A/ja active Pending
- 2000-12-12 KR KR1020027007697A patent/KR20020067554A/ko active IP Right Grant
- 2000-12-12 AU AU22443/01A patent/AU775741B2/en not_active Ceased
- 2000-12-12 CN CNB008189234A patent/CN1304382C/zh not_active Expired - Fee Related
- 2000-12-12 BR BR0016396-1A patent/BR0016396A/pt not_active IP Right Cessation
- 2000-12-12 DE DE60005560T patent/DE60005560T2/de not_active Expired - Lifetime
- 2000-12-12 EP EP00986154A patent/EP1242396B1/en not_active Expired - Lifetime
- 2000-12-12 AT AT00986154T patent/ATE250590T1/de not_active IP Right Cessation
- 2000-12-12 US US10/149,760 patent/US6812226B2/en not_active Expired - Fee Related
- 2000-12-12 MX MXPA02005788A patent/MXPA02005788A/es active IP Right Grant
- 2000-12-12 IL IL15008500A patent/IL150085A0/xx unknown
- 2000-12-12 WO PCT/SE2000/002504 patent/WO2001044213A1/en active IP Right Grant
-
2002
- 2002-06-03 ZA ZA200204429A patent/ZA200204429B/en unknown
- 2002-06-14 NO NO20022857A patent/NO323538B1/no unknown
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WO2001044213A1 (en) | 2001-06-21 |
CN1304382C (zh) | 2007-03-14 |
JP2003516978A (ja) | 2003-05-20 |
NO323538B1 (no) | 2007-06-04 |
DE60005560D1 (de) | 2003-10-30 |
ATE250590T1 (de) | 2003-10-15 |
US6812226B2 (en) | 2004-11-02 |
AU775741B2 (en) | 2004-08-12 |
KR20020067554A (ko) | 2002-08-22 |
NO20022857L (no) | 2002-08-01 |
US20030040513A1 (en) | 2003-02-27 |
CA2392894A1 (en) | 2001-06-21 |
EP1242396B1 (en) | 2003-09-24 |
BR0016396A (pt) | 2002-08-20 |
AU2244301A (en) | 2001-06-25 |
EP1242396A1 (en) | 2002-09-25 |
CN1434811A (zh) | 2003-08-06 |
MXPA02005788A (es) | 2002-09-18 |
ZA200204429B (en) | 2003-09-03 |
DE60005560T2 (de) | 2004-07-15 |
NO20022857D0 (no) | 2002-06-14 |
IL150085A0 (en) | 2002-12-01 |
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