ZA200204399B - Novel bisamidate phosphonate prodrugs. - Google Patents

Novel bisamidate phosphonate prodrugs.

Info

Publication number
ZA200204399B
ZA200204399B ZA200204399A ZA200204399A ZA200204399B ZA 200204399 B ZA200204399 B ZA 200204399B ZA 200204399 A ZA200204399 A ZA 200204399A ZA 200204399 A ZA200204399 A ZA 200204399A ZA 200204399 B ZA200204399 B ZA 200204399B
Authority
ZA
South Africa
Prior art keywords
phosphonate prodrugs
novel
bisamidate phosphonate
novel bisamidate
prodrugs
Prior art date
Application number
ZA200204399A
Other languages
English (en)
Inventor
Tao Jiang
Reddy K Raja
Srinivas Rao Kasibhatla
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of ZA200204399B publication Critical patent/ZA200204399B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200204399A 1999-12-22 2002-05-31 Novel bisamidate phosphonate prodrugs. ZA200204399B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17186299P 1999-12-22 1999-12-22

Publications (1)

Publication Number Publication Date
ZA200204399B true ZA200204399B (en) 2003-11-26

Family

ID=22625436

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200204399A ZA200204399B (en) 1999-12-22 2002-05-31 Novel bisamidate phosphonate prodrugs.

Country Status (20)

Country Link
US (3) US6965033B2 (fr)
EP (1) EP1240174A2 (fr)
JP (1) JP2003519154A (fr)
KR (1) KR100875335B1 (fr)
CN (2) CN1740182A (fr)
AU (1) AU784370B2 (fr)
BR (1) BR0017048A (fr)
CA (1) CA2396713A1 (fr)
CZ (1) CZ301401B6 (fr)
HK (1) HK1049841A1 (fr)
HU (1) HUP0204092A3 (fr)
IL (1) IL149887A0 (fr)
MX (1) MXPA02006156A (fr)
NO (1) NO20022932L (fr)
NZ (1) NZ519219A (fr)
PL (1) PL356525A1 (fr)
RU (2) RU2273642C2 (fr)
SK (1) SK8892002A3 (fr)
WO (1) WO2001047935A2 (fr)
ZA (1) ZA200204399B (fr)

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NO20022932L (no) 2002-08-22
MXPA02006156A (es) 2003-09-22
KR20020063248A (ko) 2002-08-01
NZ519219A (en) 2004-03-26
HUP0204092A3 (en) 2005-02-28
US20090192121A1 (en) 2009-07-30
RU2273642C2 (ru) 2006-04-10
CZ301401B6 (cs) 2010-02-17
CZ20022172A3 (cs) 2003-01-15
HK1049841A1 (zh) 2003-05-30
CN1434828A (zh) 2003-08-06
AU5244701A (en) 2001-07-09
RU2002119708A (ru) 2004-03-20
WO2001047935A3 (fr) 2002-03-21
CN100595204C (zh) 2010-03-24
WO2001047935A2 (fr) 2001-07-05
BR0017048A (pt) 2002-11-05
AU784370B2 (en) 2006-03-23
CN1740182A (zh) 2006-03-01
CA2396713A1 (fr) 2001-07-05
US20050004077A1 (en) 2005-01-06
RU2005138719A (ru) 2007-06-20
EP1240174A2 (fr) 2002-09-18
NO20022932D0 (no) 2002-06-18
JP2003519154A (ja) 2003-06-17
HUP0204092A2 (hu) 2003-03-28
SK8892002A3 (en) 2003-04-01
IL149887A0 (en) 2002-11-10
US6965033B2 (en) 2005-11-15
PL356525A1 (en) 2004-06-28
US20020173490A1 (en) 2002-11-21
KR100875335B1 (ko) 2008-12-22

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