ZA200203901B - Use of pleuromutilin derivatives for transdermal treatment of bacterial diseases. - Google Patents
Use of pleuromutilin derivatives for transdermal treatment of bacterial diseases. Download PDFInfo
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- ZA200203901B ZA200203901B ZA200203901A ZA200203901A ZA200203901B ZA 200203901 B ZA200203901 B ZA 200203901B ZA 200203901 A ZA200203901 A ZA 200203901A ZA 200203901 A ZA200203901 A ZA 200203901A ZA 200203901 B ZA200203901 B ZA 200203901B
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- CYPPCCJJKNISFK-UHFFFAOYSA-J kaolinite Chemical compound [OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[O-][Si](=O)O[Si]([O-])=O CYPPCCJJKNISFK-UHFFFAOYSA-J 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000012764 mineral filler Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 150000005199 trimethylbenzenes Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99123095 | 1999-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200203901B true ZA200203901B (en) | 2003-09-23 |
Family
ID=8239432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200203901A ZA200203901B (en) | 1999-11-22 | 2002-05-16 | Use of pleuromutilin derivatives for transdermal treatment of bacterial diseases. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6852756B1 (ru) |
| EP (1) | EP1231915B1 (ru) |
| JP (1) | JP3892298B2 (ru) |
| KR (1) | KR100529660B1 (ru) |
| CN (1) | CN100344281C (ru) |
| AR (1) | AR026523A1 (ru) |
| AT (1) | ATE289196T1 (ru) |
| AU (1) | AU764451B2 (ru) |
| BR (1) | BR0015722A (ru) |
| CA (1) | CA2386685C (ru) |
| CO (1) | CO5261531A1 (ru) |
| DE (1) | DE60018200T2 (ru) |
| DK (1) | DK1231915T3 (ru) |
| ES (1) | ES2237495T3 (ru) |
| HK (1) | HK1052643B (ru) |
| MX (1) | MXPA02005149A (ru) |
| NZ (1) | NZ518348A (ru) |
| PT (1) | PT1231915E (ru) |
| RU (1) | RU2264812C2 (ru) |
| TW (1) | TWI260220B (ru) |
| WO (1) | WO2001037828A1 (ru) |
| ZA (1) | ZA200203901B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1399128B1 (en) * | 2001-06-15 | 2006-08-30 | Innovent Technology Limited | Composition for the treatment of diseases which affect animals' hooves |
| CO5390081A1 (es) | 2001-11-28 | 2004-04-30 | Novartis Ag | Compuestos organicos |
| EP1663220B1 (en) | 2003-09-03 | 2009-12-02 | Glaxo Group Limited | Novel process for the preparation of pleuromutilin derivatives |
| GB0504314D0 (en) | 2005-03-02 | 2005-04-06 | Glaxo Group Ltd | Novel polymorph |
| EP1808431A1 (en) * | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Mutilin derivatives and their use as pharmaceutical |
| CN102415989A (zh) * | 2011-09-30 | 2012-04-18 | 上海恒丰强动物药业有限公司 | 盐酸沃尼妙林溶液剂及其制备方法 |
| BR112019009463A2 (pt) | 2016-11-09 | 2019-07-30 | Provita Eurotech Ltd | formulações antimicrobianas para o tratamento de infecções veterinárias do casco |
| GB201715122D0 (en) * | 2017-09-19 | 2017-11-01 | Omnipharm Dev Ltd | Topical anti-infective formulation |
| KR102098289B1 (ko) * | 2018-04-11 | 2020-04-07 | 경북대학교 산학협력단 | 발네물린을 유효성분으로 함유하는 골 질환 예방 또는 치료용 조성물 |
| CN109431980A (zh) * | 2018-12-27 | 2019-03-08 | 山东齐发药业有限公司 | 一种用于治疗动物皮肤细菌感染的羟啶妙林软膏剂及其制备方法 |
| CN114366732B (zh) * | 2022-02-23 | 2023-08-18 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | 泰妙菌素在制备用于治疗银屑病的药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT301752B (de) * | 1969-07-21 | 1972-09-25 | Biochemie Gmbh | Verfahren zur Herstellung neuer Pleuromutilin-Derivate |
| DE2614841A1 (de) | 1976-04-06 | 1977-10-20 | Bayer Ag | Neue pour-on-formulierungen von anthelmintika |
| EP0153277B1 (de) * | 1984-02-17 | 1987-08-26 | Sandoz Ag | Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| AT400674B (de) * | 1991-07-24 | 1996-02-26 | Biochemie Gmbh | Pharmazeutische pleuromutilin-zubereitung |
| GB9614017D0 (en) | 1996-07-04 | 1996-09-04 | Biochemie Gmbh | Organic compounds |
| GB9807503D0 (en) * | 1998-04-07 | 1998-06-10 | Smithkline Beecham Plc | Use |
-
2000
- 2000-10-24 TW TW089122288A patent/TWI260220B/zh not_active IP Right Cessation
- 2000-11-09 CO CO00085195A patent/CO5261531A1/es not_active Application Discontinuation
- 2000-11-17 AR ARP000106086A patent/AR026523A1/es unknown
- 2000-11-20 CN CNB008160600A patent/CN100344281C/zh not_active Expired - Fee Related
- 2000-11-20 US US10/130,649 patent/US6852756B1/en not_active Expired - Fee Related
- 2000-11-20 ES ES00993165T patent/ES2237495T3/es not_active Expired - Lifetime
- 2000-11-20 PT PT00993165T patent/PT1231915E/pt unknown
- 2000-11-20 CA CA002386685A patent/CA2386685C/en not_active Expired - Fee Related
- 2000-11-20 MX MXPA02005149A patent/MXPA02005149A/es active IP Right Grant
- 2000-11-20 EP EP00993165A patent/EP1231915B1/en not_active Revoked
- 2000-11-20 AT AT00993165T patent/ATE289196T1/de active
- 2000-11-20 NZ NZ518348A patent/NZ518348A/en not_active IP Right Cessation
- 2000-11-20 KR KR10-2002-7006509A patent/KR100529660B1/ko not_active IP Right Cessation
- 2000-11-20 JP JP2001539443A patent/JP3892298B2/ja not_active Expired - Fee Related
- 2000-11-20 RU RU2002116252/15A patent/RU2264812C2/ru not_active IP Right Cessation
- 2000-11-20 AU AU28365/01A patent/AU764451B2/en not_active Ceased
- 2000-11-20 DK DK00993165T patent/DK1231915T3/da active
- 2000-11-20 BR BR0015722-8A patent/BR0015722A/pt not_active Application Discontinuation
- 2000-11-20 WO PCT/EP2000/011519 patent/WO2001037828A1/en active IP Right Grant
- 2000-11-20 DE DE60018200T patent/DE60018200T2/de not_active Expired - Lifetime
-
2002
- 2002-05-16 ZA ZA200203901A patent/ZA200203901B/en unknown
-
2003
- 2003-06-27 HK HK03104606.5A patent/HK1052643B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1231915T3 (da) | 2005-05-02 |
| EP1231915B1 (en) | 2005-02-16 |
| TWI260220B (en) | 2006-08-21 |
| CN100344281C (zh) | 2007-10-24 |
| DE60018200T2 (de) | 2006-01-12 |
| WO2001037828A1 (en) | 2001-05-31 |
| AU2836501A (en) | 2001-06-04 |
| CA2386685C (en) | 2009-05-19 |
| RU2002116252A (ru) | 2004-01-20 |
| DE60018200D1 (de) | 2005-03-24 |
| NZ518348A (en) | 2003-11-28 |
| MXPA02005149A (es) | 2002-11-07 |
| HK1052643A1 (en) | 2003-09-26 |
| ATE289196T1 (de) | 2005-03-15 |
| JP3892298B2 (ja) | 2007-03-14 |
| CA2386685A1 (en) | 2001-05-31 |
| RU2264812C2 (ru) | 2005-11-27 |
| ES2237495T3 (es) | 2005-08-01 |
| KR100529660B1 (ko) | 2005-11-21 |
| CN1391472A (zh) | 2003-01-15 |
| KR20020053876A (ko) | 2002-07-05 |
| AU764451B2 (en) | 2003-08-21 |
| CO5261531A1 (es) | 2003-03-31 |
| HK1052643B (zh) | 2008-03-14 |
| JP2003514856A (ja) | 2003-04-22 |
| AR026523A1 (es) | 2003-02-12 |
| PT1231915E (pt) | 2005-07-29 |
| EP1231915A1 (en) | 2002-08-21 |
| BR0015722A (pt) | 2002-07-23 |
| US6852756B1 (en) | 2005-02-08 |
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