ZA200203165B - 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclo-oxygenase-2 and pharmaceutical compositions containing them. - Google Patents

5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclo-oxygenase-2 and pharmaceutical compositions containing them.

Info

Publication number
ZA200203165B
ZA200203165B ZA200203165A ZA200203165A ZA200203165B ZA 200203165 B ZA200203165 B ZA 200203165B ZA 200203165 A ZA200203165 A ZA 200203165A ZA 200203165 A ZA200203165 A ZA 200203165A ZA 200203165 B ZA200203165 B ZA 200203165B
Authority
ZA
South Africa
Prior art keywords
inhibitors
aryl
pharmaceutical compositions
oxygenase
cyclo
Prior art date
Application number
ZA200203165A
Other languages
English (en)
Inventor
Jean-Claude Pascal
Denis Carniato
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of ZA200203165B publication Critical patent/ZA200203165B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200203165A 1999-11-09 2002-04-22 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclo-oxygenase-2 and pharmaceutical compositions containing them. ZA200203165B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (fr) 1999-11-09 1999-11-09 Dérivés de 5-aryl-1H-1,2,4-triazole comme inhibiteurs de la cyclooxygénase-2 et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ZA200203165B true ZA200203165B (en) 2003-06-25

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200203165A ZA200203165B (en) 1999-11-09 2002-04-22 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclo-oxygenase-2 and pharmaceutical compositions containing them.

Country Status (24)

Country Link
US (1) US6803380B1 (fr)
EP (2) EP1099695A1 (fr)
JP (1) JP4786846B2 (fr)
CN (1) CN1198807C (fr)
AT (1) ATE245148T1 (fr)
AU (1) AU778819B2 (fr)
BR (1) BR0015440A (fr)
CA (1) CA2390649C (fr)
CZ (1) CZ20021591A3 (fr)
DE (1) DE60003949T2 (fr)
DK (1) DK1246809T3 (fr)
ES (1) ES2203538T3 (fr)
HU (1) HUP0203376A3 (fr)
IL (2) IL149370A0 (fr)
MX (1) MXPA01012903A (fr)
NO (1) NO328008B1 (fr)
NZ (1) NZ518682A (fr)
PL (1) PL204230B1 (fr)
PT (1) PT1246809E (fr)
RU (1) RU2249588C2 (fr)
SI (1) SI1246809T1 (fr)
TW (1) TWI268925B (fr)
WO (1) WO2001034577A1 (fr)
ZA (1) ZA200203165B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1273582B1 (fr) 2001-07-05 2005-06-29 Pfizer Products Inc. Pyrazoles heterocycliques alkylsulfoniques comme agents anti-inflammatoires/analgésiques
DE60204633T2 (de) 2001-07-05 2006-06-14 Pfizer Prod Inc Sulfonyl-Heteroaryl-Triazole als entzündungshemmende und analgetische Mittel
CA2390181A1 (fr) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonylaryltriazoles utilises comme agents anti-inflammatoires/analgesiques
KR100824233B1 (ko) * 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (fr) 2001-11-02 2003-05-08 Pfizer Products Inc. Derives de 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile et autres composes utilises en tant qu'inhibiteurs de la cyclooxygenase dans le traitement de l'arthrite, de la neurodegeneration et du cancer du colon
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) * 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (fr) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Derives d'imidazole et de triazole utiles en tant qu'inhibiteurs de cox-1 selectifs
JP5138582B2 (ja) * 2005-04-28 2013-02-06 チバ ホールディング インコーポレーテッド 電子発光装置
US20100256357A1 (en) * 2006-08-09 2010-10-07 Agouron Pharmaceuticals, Inc. Heterocycles useful as inhibitors of carbonic anhydrase
WO2012070596A1 (fr) * 2010-11-26 2012-05-31 Semiconductor Energy Laboratory Co., Ltd. Complexe organométallique, élément émettant de la lumière, dispositif émettant de la lumière, dispositif électronique et dispositif d'éclairage
WO2012170839A2 (fr) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Traitement d'une maladie neuro-inflammatoire par des inhibiteurs sélectifs de cox1
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
JP2021516238A (ja) 2018-03-08 2021-07-01 バイエル・アクチエンゲゼルシヤフト 植物保護における殺有害生物剤としてのヘテロアリール−トリアゾール化合物及びヘテロアリール−テトラゾール化合物の使用
EP3904349B1 (fr) 2018-04-12 2023-08-23 Bayer Aktiengesellschaft Dérivés de n-(cyclopropylméthyl)-5-(méthylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]éthyl}heterocyclyl amide et composés similaires en tant que pesticides
SG11202010068VA (en) 2018-04-25 2020-11-27 Bayer Ag Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
TW202118391A (zh) 2019-07-23 2021-05-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基三唑化合物（二）
CN118496198A (zh) 2019-07-23 2024-08-16 拜耳公司 作为农药的新的杂芳基-三唑化合物
EP4041393A1 (fr) 2019-10-09 2022-08-17 Bayer Aktiengesellschaft Nouveaux composés hétéroaryle-triazole utilisés comme pesticides
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
US20230148601A1 (en) 2020-02-18 2023-05-18 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (fr) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
JP4786846B2 (ja) 2011-10-05
CN1387517A (zh) 2002-12-25
NO20022202D0 (no) 2002-05-08
SI1246809T1 (en) 2004-02-29
PL204230B1 (pl) 2009-12-31
JP2003513961A (ja) 2003-04-15
EP1246809A1 (fr) 2002-10-09
EP1246809B1 (fr) 2003-07-16
IL149370A (en) 2007-06-17
AU778819B2 (en) 2004-12-23
NZ518682A (en) 2003-07-25
CN1198807C (zh) 2005-04-27
HUP0203376A2 (hu) 2003-01-28
EP1099695A1 (fr) 2001-05-16
WO2001034577A1 (fr) 2001-05-17
NO328008B1 (no) 2009-11-09
AU1998501A (en) 2001-06-06
MXPA01012903A (es) 2002-11-07
DK1246809T3 (da) 2003-10-20
US6803380B1 (en) 2004-10-12
DE60003949D1 (de) 2003-08-21
HUP0203376A3 (en) 2004-12-28
ATE245148T1 (de) 2003-08-15
IL149370A0 (en) 2002-11-10
ES2203538T3 (es) 2004-04-16
CZ20021591A3 (cs) 2002-07-17
TWI268925B (en) 2006-12-21
RU2249588C2 (ru) 2005-04-10
NO20022202L (no) 2002-05-08
PT1246809E (pt) 2003-11-28
CA2390649A1 (fr) 2001-05-17
DE60003949T2 (de) 2004-05-27
PL356120A1 (en) 2004-06-14
CA2390649C (fr) 2008-05-06
BR0015440A (pt) 2002-07-02

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