WO2000037465A3 - Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques - Google Patents

Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques Download PDF

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Publication number
WO2000037465A3
WO2000037465A3 PCT/CA1999/001210 CA9901210W WO0037465A3 WO 2000037465 A3 WO2000037465 A3 WO 2000037465A3 CA 9901210 W CA9901210 W CA 9901210W WO 0037465 A3 WO0037465 A3 WO 0037465A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
preparation
therapeutic agents
swainsonine
novel derivatives
Prior art date
Application number
PCT/CA1999/001210
Other languages
English (en)
Other versions
WO2000037465A2 (fr
Inventor
Francois D Tropper
Cheng Guo
Rajan N Shah
Original Assignee
Glycodesign Inc
Francois D Tropper
Cheng Guo
Rajan N Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycodesign Inc, Francois D Tropper, Cheng Guo, Rajan N Shah filed Critical Glycodesign Inc
Priority to CA002352858A priority Critical patent/CA2352858A1/fr
Priority to AU17643/00A priority patent/AU1764300A/en
Publication of WO2000037465A2 publication Critical patent/WO2000037465A2/fr
Publication of WO2000037465A3 publication Critical patent/WO2000037465A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de swainsonine 8a substitués, des procédés destinés à leur préparation, et leurs utilisations comme agents thérapeutiques. L'invention concerne aussi des compositions pharmaceutiques contenant ces composés ainsi que leurs utilisations comme agents thérapeutiques.
PCT/CA1999/001210 1998-12-18 1999-12-17 Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques WO2000037465A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002352858A CA2352858A1 (fr) 1998-12-18 1999-12-17 Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques
AU17643/00A AU1764300A (en) 1998-12-18 1999-12-17 Novel derivatives of swainsonine, processes for their preparation, and their useas therapeutic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11293098P 1998-12-18 1998-12-18
US60/112,930 1998-12-18

Publications (2)

Publication Number Publication Date
WO2000037465A2 WO2000037465A2 (fr) 2000-06-29
WO2000037465A3 true WO2000037465A3 (fr) 2000-09-08

Family

ID=22346611

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/001210 WO2000037465A2 (fr) 1998-12-18 1999-12-17 Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques

Country Status (3)

Country Link
AU (1) AU1764300A (fr)
CA (1) CA2352858A1 (fr)
WO (1) WO2000037465A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286766A1 (fr) 1997-04-15 1998-10-22 Glycodesign Inc. Sels halogenes d'alcaloide de swainsonine et procedes d'utilisation
GB0401238D0 (en) * 2004-01-21 2004-02-25 Molecularnature Ltd Immunomodulatory alkaloids
CN102432609A (zh) * 2011-12-15 2012-05-02 西藏自治区农牧科学院 一种茎直黄芪中苦马豆素的微波辅助提取工艺
CN103319481B (zh) * 2013-07-05 2014-12-17 西藏自治区农牧科学院 茎直黄芪中苦马豆素的提取工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633261A (en) * 1991-11-06 1997-05-27 Toronto Research Chemicals, Inc. Immunostimulating swainsonine analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633261A (en) * 1991-11-06 1997-05-27 Toronto Research Chemicals, Inc. Immunostimulating swainsonine analogs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. M. MCINTOSH: "Azapropellanes as phase-transfer catalysts-II", TETRAHEDRON., vol. 38, no. 2, 1982, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 261 - 6, XP002138010, ISSN: 0040-4020 *
M.G. REINECKE ET AL.: "Peripheral synthesis of secondary medium-ring nitrogen heterocycles", JOURNAL OF ORGANIC CHEMISTRY., vol. 38, no. 19, 1973, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 3281 - 87, XP002138009, ISSN: 0022-3263 *
M.G. REINECKE ET AL.: "The peripheral synthesis of medium-ring nitrogen heterocycles by displacement reactions", JOURNAL OF ORGANIC CHEMISTRY., vol. 37, no. 22, 1972, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 3494 - 99, XP002138011, ISSN: 0022-3263 *
S.F. MARTIN ET AL.: "Application of reductive, single electron transfer processes to the generation and cyclization of omega-unsaturated and alpha-amino radicals", TETRAHEDRON LETTERS., vol. 29, no. 51, 1988, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 6685 - 88, XP002138008, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU1764300A (en) 2000-07-12
CA2352858A1 (fr) 2000-06-29
WO2000037465A2 (fr) 2000-06-29

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