ZA200202162B - Parathyroid hormone analogues for the treatment of osteoporosis. - Google Patents

Parathyroid hormone analogues for the treatment of osteoporosis. Download PDF

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Publication number
ZA200202162B
ZA200202162B ZA200202162A ZA200202162A ZA200202162B ZA 200202162 B ZA200202162 B ZA 200202162B ZA 200202162 A ZA200202162 A ZA 200202162A ZA 200202162 A ZA200202162 A ZA 200202162A ZA 200202162 B ZA200202162 B ZA 200202162B
Authority
ZA
South Africa
Prior art keywords
analogue
leu
lys
glu
amino acid
Prior art date
Application number
ZA200202162A
Other languages
English (en)
Inventor
Jean-Rene Barbier
James Whitfield
Paul Morley
Gordon E Willick
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of ZA200202162B publication Critical patent/ZA200202162B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200202162A 1999-09-22 2002-03-15 Parathyroid hormone analogues for the treatment of osteoporosis. ZA200202162B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/406,813 US6316410B1 (en) 1999-09-22 1999-09-22 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (1)

Publication Number Publication Date
ZA200202162B true ZA200202162B (en) 2003-08-27

Family

ID=23609550

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200202162A ZA200202162B (en) 1999-09-22 2002-03-15 Parathyroid hormone analogues for the treatment of osteoporosis.

Country Status (13)

Country Link
US (1) US6316410B1 (ja)
EP (2) EP1881006A1 (ja)
JP (1) JP4620309B2 (ja)
CN (1) CN1377371A (ja)
AU (1) AU7398000A (ja)
BR (1) BR0016306A (ja)
CA (1) CA2384341A1 (ja)
CZ (1) CZ20021026A3 (ja)
IL (1) IL148654A0 (ja)
MX (1) MXPA02002977A (ja)
SK (1) SK4042002A3 (ja)
WO (1) WO2001021643A2 (ja)
ZA (1) ZA200202162B (ja)

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AUPQ553800A0 (en) * 2000-02-10 2000-03-02 Cole, Martin Terence Improvements relating to smoke detectors particularily duct monitored smoke detectors
WO2003097690A2 (en) * 2002-05-16 2003-11-27 Theratechnologies Inc. Pth derivatives resistant to skin proteases
WO2003105772A2 (en) * 2002-06-13 2003-12-24 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
US7635477B2 (en) 2002-07-25 2009-12-22 The General Hospital Corporation Parathyroid hormone receptor activation and stem and progenitor cell expansion
WO2004011484A2 (en) * 2002-07-25 2004-02-05 The General Hospital Corporation Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
BRPI0412664A (pt) * 2003-07-15 2006-09-26 Ca Nat Research Council método para tratar uma condição caracterizada por hiperproliferação de células da pele em um indivìduo em risco ou portador dessa condição e utilização de uma quantidade terapeuticamente efetiva de um análogo cìclico de hormÈnio de paratireóide humano (hpth)
EP1557176A1 (en) * 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20090047347A1 (en) * 2005-07-29 2009-02-19 Aegis Therapeutics, Inc. Compositions for Drug Administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US9114069B2 (en) * 2004-08-25 2015-08-25 Aegis Therapeutics, Llc Antibacterial compositions for drug administration
US8642564B2 (en) * 2004-08-25 2014-02-04 Aegis Therapeutics, Llc Compositions for drug administration
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US20060046969A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Antibacterial compositions for drug administration
AU2006343306A1 (en) * 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
US20110046059A1 (en) * 2005-09-06 2011-02-24 Zelos Therapeutics, Inc. Pharmaceutically acceptable formulations/compositions for peptidyl drugs
JP2009515535A (ja) * 2005-11-10 2009-04-16 ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
EP2056862A2 (en) * 2006-07-31 2009-05-13 Zelos Therapeutics, Inc. Parathyroid hormone analogues and uses thereof
DK2084183T3 (da) * 2006-10-13 2010-08-16 Lilly Co Eli Pegyleret PTH som PTH-receptormodulatorer og anvendelser deraf
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
EP2271347B1 (en) 2008-03-28 2016-05-11 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
US8440631B2 (en) * 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
CN102448482A (zh) 2009-03-27 2012-05-09 范安德尔研究所 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法
EP2509996A1 (en) 2009-12-07 2012-10-17 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
EP2720699B1 (en) 2011-06-14 2018-05-16 Hale Biopharma Ventures, Llc Administration of benzodiazepine
MX2017013802A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
MX2019007748A (es) 2017-01-05 2019-09-09 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
DE19508672A1 (de) 1995-03-10 1996-09-12 Boehringer Mannheim Gmbh Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
AU723728B2 (en) 1996-08-02 2000-09-07 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
JP2001517957A (ja) 1997-05-14 2001-10-09 アヴェンティス ファーマシューティカルズ プロダクツ インコーポレイテッド ペプチド副甲状腺ホルモン類縁体

Also Published As

Publication number Publication date
IL148654A0 (en) 2002-09-12
JP2003510256A (ja) 2003-03-18
MXPA02002977A (es) 2004-09-06
EP1881006A1 (en) 2008-01-23
CN1377371A (zh) 2002-10-30
CA2384341A1 (en) 2001-03-29
WO2001021643A2 (en) 2001-03-29
WO2001021643A3 (en) 2001-10-25
BR0016306A (pt) 2003-04-08
US6316410B1 (en) 2001-11-13
JP4620309B2 (ja) 2011-01-26
AU7398000A (en) 2001-04-24
CZ20021026A3 (cs) 2003-05-14
SK4042002A3 (en) 2002-12-03
EP1214348A2 (en) 2002-06-19

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