BR0016306A - Análogos do hormÈnio para tireóide para o tratamento da osteoporose - Google Patents

Análogos do hormÈnio para tireóide para o tratamento da osteoporose

Info

Publication number
BR0016306A
BR0016306A BR0016306-6A BR0016306A BR0016306A BR 0016306 A BR0016306 A BR 0016306A BR 0016306 A BR0016306 A BR 0016306A BR 0016306 A BR0016306 A BR 0016306A
Authority
BR
Brazil
Prior art keywords
analogs
cyclized
cycle
amino acid
parathyroid hormone
Prior art date
Application number
BR0016306-6A
Other languages
English (en)
Inventor
Jean-Rene Barbier
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of BR0016306A publication Critical patent/BR0016306A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"ANáLOGOS DO HORMÈNIO PARATIREóIDE PARA O TRATAMENTO DA OSTEOPOROSE". A invenção exposta se relaciona a análogos do hormónio paratireóide humano (HPTH) que têm atividades maiores na restauração óssea, e maiores biodisponibilidades. Os análogos descritos são ou os análogos cíclicos (1-28) ou (1-29), ou análogos de dois ciclos (1-28) a (1-31). Os análogos de um ciclo são ciclizados entre pares de aminoácidos R22 e R26. Os análogos de dois ciclos são ciclizados entre pares de aminoácidos 13 17 e 22 - 26. Também são descritas várias substituições dos resíduos naturais por outros aminoácidos. Por exemplo, o resíduo natural Lys27 pode ser substituído por Leu. Tipicamente, estes análogos novos têm habilidades aprimoradas para estimular a atividade da ciclase de adenila em células de osteosarcomas de ratos, e apresentam atividades maiores na restauração óssea usando o modelo de rato ovário ectomizado.
BR0016306-6A 1999-09-22 2000-09-21 Análogos do hormÈnio para tireóide para o tratamento da osteoporose BR0016306A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/406,813 US6316410B1 (en) 1999-09-22 1999-09-22 Parathyroid hormone analogues for the treatment of osteoporosis
PCT/CA2000/001083 WO2001021643A2 (en) 1999-09-22 2000-09-21 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (1)

Publication Number Publication Date
BR0016306A true BR0016306A (pt) 2003-04-08

Family

ID=23609550

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016306-6A BR0016306A (pt) 1999-09-22 2000-09-21 Análogos do hormÈnio para tireóide para o tratamento da osteoporose

Country Status (13)

Country Link
US (1) US6316410B1 (pt)
EP (2) EP1214348A2 (pt)
JP (1) JP4620309B2 (pt)
CN (1) CN1377371A (pt)
AU (1) AU7398000A (pt)
BR (1) BR0016306A (pt)
CA (1) CA2384341A1 (pt)
CZ (1) CZ20021026A3 (pt)
IL (1) IL148654A0 (pt)
MX (1) MXPA02002977A (pt)
SK (1) SK4042002A3 (pt)
WO (1) WO2001021643A2 (pt)
ZA (1) ZA200202162B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ553800A0 (en) * 2000-02-10 2000-03-02 Cole, Martin Terence Improvements relating to smoke detectors particularily duct monitored smoke detectors
US20040023882A1 (en) * 2002-05-16 2004-02-05 Peri Krishna G. PTH derivatives resistant to skin proteases
WO2003105772A2 (en) * 2002-06-13 2003-12-24 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
US7635477B2 (en) * 2002-07-25 2009-12-22 The General Hospital Corporation Parathyroid hormone receptor activation and stem and progenitor cell expansion
AU2003256839B2 (en) * 2002-07-25 2009-10-29 The General Hospital Corporation Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
JP2007533596A (ja) * 2003-07-15 2007-11-22 ナショナル・リサーチ・カウンシル・オブ・カナダ 異常増殖性皮膚細胞を特徴とする状態の処置のためのヒト副甲状腺ホルモンの環状アナログ
EP1557176A1 (en) * 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20060046969A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Antibacterial compositions for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US20090047347A1 (en) * 2005-07-29 2009-02-19 Aegis Therapeutics, Inc. Compositions for Drug Administration
US8642564B2 (en) * 2004-08-25 2014-02-04 Aegis Therapeutics, Llc Compositions for drug administration
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US9114069B2 (en) * 2004-08-25 2015-08-25 Aegis Therapeutics, Llc Antibacterial compositions for drug administration
US20060046962A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
EP1933863A4 (en) * 2005-09-06 2010-06-09 Zelos Therapeutics Inc PARATHYROIDIAN HORMONE ANALOGS AND METHODS USING SAME
US20110046059A1 (en) * 2005-09-06 2011-02-24 Zelos Therapeutics, Inc. Pharmaceutically acceptable formulations/compositions for peptidyl drugs
WO2007059470A2 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
JP2010501476A (ja) * 2006-07-31 2010-01-21 ゼロス セラピューティクス， インコーポレイテッド 副甲状腺ホルモン類似体およびその使用方法
SI2084183T1 (sl) * 2006-10-13 2010-09-30 Lilly Co Eli Pegilirani pth kot modulatorji pth receptorja in njihove uporabe
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
EP2271347B1 (en) 2008-03-28 2016-05-11 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
US8563513B2 (en) 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
JP2013512688A (ja) 2009-12-07 2013-04-18 ミシガン テクノロジカル ユニバーシティ クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
ES2917973T3 (es) 2011-06-14 2022-07-12 Neurelis Inc Administración de benzodiacepina
AU2016256470B2 (en) 2015-04-29 2020-10-15 Radius Pharmaceuticals, Inc. Methods of treating cancer
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
LT3565542T (lt) 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2126299C (en) * 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
DE19508672A1 (de) 1995-03-10 1996-09-12 Boehringer Mannheim Gmbh Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
WO1998005683A1 (en) 1996-08-02 1998-02-12 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
IL132901A0 (en) 1997-05-14 2001-03-19 Aventis Pharm Prod Inc Peptide parathyroid hormone analogs

Also Published As

Publication number Publication date
SK4042002A3 (en) 2002-12-03
IL148654A0 (en) 2002-09-12
ZA200202162B (en) 2003-08-27
AU7398000A (en) 2001-04-24
CA2384341A1 (en) 2001-03-29
US6316410B1 (en) 2001-11-13
WO2001021643A3 (en) 2001-10-25
CN1377371A (zh) 2002-10-30
EP1214348A2 (en) 2002-06-19
EP1881006A1 (en) 2008-01-23
WO2001021643A2 (en) 2001-03-29
CZ20021026A3 (cs) 2003-05-14
JP2003510256A (ja) 2003-03-18
MXPA02002977A (es) 2004-09-06
JP4620309B2 (ja) 2011-01-26

Similar Documents

Publication Publication Date Title
BR0016306A (pt) Análogos do hormÈnio para tireóide para o tratamento da osteoporose
RU2224539C2 (ru) Заживление переломов с помощью аналогов пептида, подобного паратироидному гормону (ртнrр)
ROSENBLATT et al. Identification of a receptor-binding region in parathyroid hormone
PT83278A (en) Process for the preparation of insulin analogues and of injectable insulin solutions containing the same
BR9711002A (pt) Análogos ao hormÈnio da paratireóide para o tratamento da osteoporose
RU2000109305A (ru) ЗАЖИВЛЕНИЕ ПЕРЕЛОМОВ С ПОМОЩЬЮ АНАЛОГОВ ПЕПТИДА, ПОДОБНОГО ПАРАТИРЕОИДНОМУ ГОРМОНУ (РТНrР)
DK155686A (da) Parathyroidhormonholdigt praeparat
AP2000001888A0 (en) Method for treatment of diabetes using peptides analogues of insulin.
PL191898B1 (pl) Wariant peptydu ludzkiego hormonu przytarczyc oraz wariant peptydu białka pokrewnego ludzkiemu hormonowi przytarczyc
BR9811755A (pt) Peptìdeo, processo para o tratamento da obesidade em um animal, uso de um peptìdeo, e, composição farmacêutica
Huang et al. Parathyroid hormone stimulates adenylate cyclase in rat cerebral microvessels
STOUFFER et al. Reversible binding of ACTH to a glass surface
BR9201512A (pt) Composto,formulacao farmaceutica,processo de preparar um analogico de grf e analago de grf ogtido
STURM et al. Structure‐activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon
KR920700224A (ko) 신규의 생리활성 펩티드 및 이를 유효성분으로서 함유한 칼슘대사 조절제
PT94233A (pt) Processo para a preparacao de peptidos biologicamente activos e composicoes farmeceuticas que os contem
DK119391A (da) Humaninsulinanaloger

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.