ZA200201637B - Treatment of migraine by the administration of alpha-lipoic acid or derivatives thereof. - Google Patents
Treatment of migraine by the administration of alpha-lipoic acid or derivatives thereof. Download PDFInfo
- Publication number
- ZA200201637B ZA200201637B ZA200201637A ZA200201637A ZA200201637B ZA 200201637 B ZA200201637 B ZA 200201637B ZA 200201637 A ZA200201637 A ZA 200201637A ZA 200201637 A ZA200201637 A ZA 200201637A ZA 200201637 B ZA200201637 B ZA 200201637B
- Authority
- ZA
- South Africa
- Prior art keywords
- use according
- lipoic acid
- active ingredient
- migraine
- racemic
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title claims description 34
- 206010027599 migraine Diseases 0.000 title claims description 34
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title claims description 21
- 238000011282 treatment Methods 0.000 title claims description 8
- 229960002663 thioctic acid Drugs 0.000 title claims description 7
- 235000019136 lipoic acid Nutrition 0.000 title description 3
- 239000004480 active ingredient Substances 0.000 claims description 19
- MUZIZEZCKKMZRT-UHFFFAOYSA-N 1,2-dithiolane Chemical group C1CSSC1 MUZIZEZCKKMZRT-UHFFFAOYSA-N 0.000 claims description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
- 150000001408 amides Chemical class 0.000 claims description 5
- 230000001684 chronic effect Effects 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 230000001154 acute effect Effects 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
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- 150000001875 compounds Chemical class 0.000 claims description 3
- 235000015872 dietary supplement Nutrition 0.000 claims description 3
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 claims description 3
- 229960004943 ergotamine Drugs 0.000 claims description 3
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical group CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims description 3
- 229960003708 sumatriptan Drugs 0.000 claims description 3
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- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical group CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims description 2
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- IZFHEQBZOYJLPK-ZETCQYMHSA-N (S)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@H](S)CCS IZFHEQBZOYJLPK-ZETCQYMHSA-N 0.000 description 1
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- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19941217A DE19941217A1 (de) | 1999-08-30 | 1999-08-30 | Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200201637B true ZA200201637B (en) | 2003-01-29 |
Family
ID=7920152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200201637A ZA200201637B (en) | 1999-08-30 | 2002-02-27 | Treatment of migraine by the administration of alpha-lipoic acid or derivatives thereof. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6251935B1 (ru) |
| EP (1) | EP1207878B1 (ru) |
| JP (1) | JP4773015B2 (ru) |
| KR (1) | KR100624215B1 (ru) |
| CN (1) | CN1170535C (ru) |
| AT (1) | ATE232725T1 (ru) |
| AU (1) | AU781505B2 (ru) |
| BG (1) | BG65735B1 (ru) |
| BR (1) | BR0013651A (ru) |
| CA (1) | CA2382548C (ru) |
| CZ (1) | CZ301789B6 (ru) |
| DE (2) | DE19941217A1 (ru) |
| DK (1) | DK1207878T3 (ru) |
| EE (1) | EE04869B1 (ru) |
| ES (1) | ES2190985T3 (ru) |
| HK (1) | HK1046637A1 (ru) |
| HR (1) | HRP20020168A2 (ru) |
| HU (1) | HU229603B1 (ru) |
| IL (2) | IL148068A0 (ru) |
| IS (1) | IS2214B (ru) |
| MX (1) | MXPA02002246A (ru) |
| NO (1) | NO328692B1 (ru) |
| NZ (1) | NZ517276A (ru) |
| PL (1) | PL200928B1 (ru) |
| PT (1) | PT1207878E (ru) |
| RS (1) | RS50139B (ru) |
| RU (1) | RU2232577C2 (ru) |
| SK (1) | SK286260B6 (ru) |
| TR (1) | TR200200461T2 (ru) |
| UA (1) | UA71031C2 (ru) |
| WO (1) | WO2001015693A2 (ru) |
| ZA (1) | ZA200201637B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2352144A1 (en) * | 1998-11-25 | 2000-06-02 | Yissum Research Development Company Of The Hebrew University In Jerusale M | Scavenger compounds |
| US7030154B2 (en) | 2002-06-07 | 2006-04-18 | Juvenon, Inc. | Stability of lipoic acid |
| US20050065094A1 (en) | 2003-09-05 | 2005-03-24 | Boehringer Ingelheim International Gmbh | Use of telmisartan for the prevention and treatment of vascular headache |
| US20050282879A1 (en) * | 2004-06-17 | 2005-12-22 | Foad Salehani | Methods and composition for treatment of migraine and symptoms thereof |
| US20090054513A1 (en) * | 2007-08-22 | 2009-02-26 | Response Scientific, Inc. | Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease |
| US7943163B2 (en) | 2007-08-22 | 2011-05-17 | Response Scientific, Inc. | Medical food or nutritional supplement, method of manufacturing same, and method of managing diabetes |
| KR101493125B1 (ko) | 2008-11-24 | 2015-02-12 | 세다르스-신나이 메디칼 센터 | 항산화성 캠토테신 유도체 및 이들의 항산화성 항종양성 나노구체 |
| EP2429991B1 (en) | 2009-05-15 | 2014-09-10 | Redx Pharma Limited | Redox drug derivatives |
| KR100935554B1 (ko) | 2009-06-24 | 2010-01-07 | 주식회사 셀트리온제약 | 피페라진 다이티옥트산염 및 이를 포함하는 약제학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU620265A1 (ru) * | 1977-02-21 | 1978-08-25 | Центральный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Курортологии И Физиотерапии | Способ лечени атеросклероза сосудов головного мозга и гипертонической болезни |
| ES2043897T3 (es) * | 1988-01-28 | 1994-01-01 | Koeltringer Peter | Preparado de combinacion, en especial para el tratamiento de enfermedades de las celulas nerviosas. |
| JPH03169813A (ja) * | 1989-11-09 | 1991-07-23 | Asta Pharma Ag | 細胞保護作用を有する疼痛及び炎症性疾患及び／又はレトロウイルスに起因する病気の治療用医薬並びにその製法 |
| US5569670A (en) * | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
| DE4218572A1 (de) * | 1992-06-05 | 1993-12-09 | Asta Medica Ag | Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E |
| DE69331727D1 (de) * | 1992-06-30 | 2002-04-25 | Howard K Shapiro | Verwendung einer kombination bestehend aus einem aminderivat oder aminverwandten derivat der benzoesäure und einem amino-polysaccharide zur herstellung eines medikaments fuer die behandlung von entzündlichen erkrankungen |
| DE4327426A1 (de) * | 1993-08-14 | 1995-02-16 | F H Erdaussiebung Gmbh | Anbaugerät zum Sieben und Verfüllen von Erdmaterialien |
| DE4327462A1 (de) * | 1993-08-16 | 1995-02-23 | Carl Heinrich Dr Weischer | Neue N-Acetyl-p-Aminophenol-Derivate zur Bekämpfung von Schmerzzuständen |
| DE4331168A1 (de) * | 1993-09-14 | 1995-03-16 | Carl Heinrich Dr Weischer | Kombination von N-Acetyl-p-Aminophenol mit schwefelenthaltenden Carbonsäuren, wie z. B. alpha-Liponsäure und deren Derivate, zur Bekämpfung von Schmerzzuständen |
| EP0855396A1 (en) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Thioctic acid metabolites and methods of use thereof |
| IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
| AU8768098A (en) * | 1997-08-04 | 1999-02-22 | Christopher J. Berry | Method of treating disease using a tocotrienol and alpha-lipoic acid r derivatives or an ester thereof |
| GB2333757B (en) * | 1998-02-03 | 2001-06-27 | Cheung Kwok Chung | Sliding platform |
| EP1065931A4 (en) * | 1998-04-02 | 2006-10-11 | Avicena Group Inc | COMPOSITIONS CONTAINING CREATINE COMBINED WITH A SECOND AGENT |
| AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
-
1999
- 1999-08-30 DE DE19941217A patent/DE19941217A1/de not_active Ceased
-
2000
- 2000-08-15 US US09/638,034 patent/US6251935B1/en not_active Expired - Lifetime
- 2000-08-26 KR KR1020027002638A patent/KR100624215B1/ko not_active IP Right Cessation
- 2000-08-26 BR BR0013651-4A patent/BR0013651A/pt not_active Application Discontinuation
- 2000-08-26 AU AU72799/00A patent/AU781505B2/en not_active Ceased
- 2000-08-26 TR TR2002/00461T patent/TR200200461T2/xx unknown
- 2000-08-26 SK SK290-2002A patent/SK286260B6/sk not_active IP Right Cessation
- 2000-08-26 CZ CZ20020655A patent/CZ301789B6/cs not_active IP Right Cessation
- 2000-08-26 IL IL14806800A patent/IL148068A0/xx active IP Right Grant
- 2000-08-26 UA UA2002032400A patent/UA71031C2/ru unknown
- 2000-08-26 AT AT00960527T patent/ATE232725T1/de active
- 2000-08-26 RS YUP-150/02A patent/RS50139B/sr unknown
- 2000-08-26 HU HU0203025A patent/HU229603B1/hu not_active IP Right Cessation
- 2000-08-26 JP JP2001519907A patent/JP4773015B2/ja not_active Expired - Fee Related
- 2000-08-26 DK DK00960527T patent/DK1207878T3/da active
- 2000-08-26 RU RU2002106751/14A patent/RU2232577C2/ru active
- 2000-08-26 PT PT00960527T patent/PT1207878E/pt unknown
- 2000-08-26 EE EEP200200098A patent/EE04869B1/xx not_active IP Right Cessation
- 2000-08-26 CA CA002382548A patent/CA2382548C/en not_active Expired - Fee Related
- 2000-08-26 WO PCT/EP2000/008315 patent/WO2001015693A2/de active IP Right Grant
- 2000-08-26 DE DE50001301T patent/DE50001301D1/de not_active Expired - Lifetime
- 2000-08-26 MX MXPA02002246A patent/MXPA02002246A/es active IP Right Grant
- 2000-08-26 ES ES00960527T patent/ES2190985T3/es not_active Expired - Lifetime
- 2000-08-26 EP EP00960527A patent/EP1207878B1/de not_active Expired - Lifetime
- 2000-08-26 PL PL352741A patent/PL200928B1/pl unknown
- 2000-08-26 CN CNB008122032A patent/CN1170535C/zh not_active Expired - Fee Related
- 2000-08-26 NZ NZ517276A patent/NZ517276A/en not_active IP Right Cessation
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2002
- 2002-02-06 IL IL148068A patent/IL148068A/en not_active IP Right Cessation
- 2002-02-12 BG BG106407A patent/BG65735B1/bg unknown
- 2002-02-25 NO NO20020917A patent/NO328692B1/no not_active IP Right Cessation
- 2002-02-26 IS IS6284A patent/IS2214B/is unknown
- 2002-02-26 HR HR20020168A patent/HRP20020168A2/hr not_active Application Discontinuation
- 2002-02-27 ZA ZA200201637A patent/ZA200201637B/en unknown
- 2002-11-09 HK HK02108150A patent/HK1046637A1/xx not_active IP Right Cessation
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