ZA200106688B - Combinations for the treatment of diseases involving angiogenesis. - Google Patents
Combinations for the treatment of diseases involving angiogenesis. Download PDFInfo
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- ZA200106688B ZA200106688B ZA200106688A ZA200106688A ZA200106688B ZA 200106688 B ZA200106688 B ZA 200106688B ZA 200106688 A ZA200106688 A ZA 200106688A ZA 200106688 A ZA200106688 A ZA 200106688A ZA 200106688 B ZA200106688 B ZA 200106688B
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- South Africa
- Prior art keywords
- nitric oxide
- inhibitor
- damaging agent
- vascular damaging
- composition according
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Electrotherapy Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903404.3A GB9903404D0 (en) | 1999-02-16 | 1999-02-16 | Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200106688B true ZA200106688B (en) | 2002-08-14 |
Family
ID=10847791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200106688A ZA200106688B (en) | 1999-02-16 | 2001-08-14 | Combinations for the treatment of diseases involving angiogenesis. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7087627B1 (de) |
| EP (1) | EP1161235B1 (de) |
| JP (1) | JP4708569B2 (de) |
| KR (2) | KR20010102038A (de) |
| CN (1) | CN1344159B (de) |
| AT (1) | ATE288264T1 (de) |
| AU (1) | AU775242B2 (de) |
| BR (1) | BR0008254A (de) |
| CA (1) | CA2362281C (de) |
| DE (1) | DE60017878T2 (de) |
| DK (1) | DK1161235T3 (de) |
| ES (1) | ES2237407T3 (de) |
| GB (1) | GB9903404D0 (de) |
| HK (1) | HK1040919B (de) |
| IL (2) | IL144847A0 (de) |
| MX (1) | MXPA01008245A (de) |
| NO (1) | NO20013966L (de) |
| NZ (1) | NZ513429A (de) |
| PT (1) | PT1161235E (de) |
| WO (1) | WO2000048591A1 (de) |
| ZA (1) | ZA200106688B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001247459A (ja) | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | 癌の組み合わせ療法 |
| EE200200565A (et) | 2000-03-31 | 2004-06-15 | Angiogene Pharmaceuticals Ltd. | Vaskulaarse kahjustava toimega kombinatsioonravi |
| WO2002009700A1 (en) | 2000-07-28 | 2002-02-07 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| US20050153939A1 (en) | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| YU29803A (sh) * | 2000-10-27 | 2006-05-25 | Aventis Pharma S.A. | Kombinacija kamptotekina i derivata stilbena za lečenje raka |
| EP1351573A4 (de) * | 2000-12-22 | 2007-03-28 | Bristol Myers Squibb Co | Verfahren zur modulation des tumorwachtums und der metastasierung |
| US20020183266A1 (en) * | 2001-03-15 | 2002-12-05 | Aventis Pharma, S.A. | Combination comprising combretastatin and anticancer agents |
| AU2008202468B2 (en) * | 2001-07-13 | 2011-08-11 | Oxigene, Inc. | Compositions and Methods of Administering Tubulin Binding Agents for the Treatment of Ocular Diseases |
| JP2004536847A (ja) * | 2001-07-13 | 2004-12-09 | オキシジーン， インコーポレイテッド | 眼の疾患の処置のためのチューブリン結合薬剤を投与するための組成物および方法 |
| EP1287854B1 (de) * | 2001-08-30 | 2005-11-30 | Cancer Research Technology Limited | Antikrebs-Kombinationen aus DMXAA und Paclitaxel oder Docetaxel |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| US20080114021A1 (en) * | 2006-11-09 | 2008-05-15 | University Of Maryland Baltimore | Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent |
| US20100087370A1 (en) * | 2007-02-14 | 2010-04-08 | The General Hospital Corporation | Modulation of nitric oxide signaling to normalize tumor vasculature |
| US20090264382A1 (en) | 2007-11-21 | 2009-10-22 | David Chaplin | Methods for Treating Hematopoietic Neoplasms |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| JP2018523712A (ja) | 2015-08-18 | 2018-08-23 | マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. | 腫瘍に対する免疫調節療法を向上させる為のｖｄａｓの使用 |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095710A (zh) | 1992-11-27 | 1994-11-30 | 惠尔康基金会集团公司 | 酶抑制剂 |
| US5554638A (en) * | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| US5424447A (en) | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
| GB9320484D0 (en) | 1993-10-05 | 1993-11-24 | Wellcome Found | Pharmaceutical combinations |
| WO1996018617A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
| WO1997032585A1 (en) * | 1996-03-05 | 1997-09-12 | Medinox, Inc. | Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| US5916910A (en) * | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
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1999
- 1999-02-16 GB GBGB9903404.3A patent/GB9903404D0/en not_active Ceased
-
2000
- 2000-02-15 EP EP00903832A patent/EP1161235B1/de not_active Expired - Lifetime
- 2000-02-15 ES ES00903832T patent/ES2237407T3/es not_active Expired - Lifetime
- 2000-02-15 AT AT00903832T patent/ATE288264T1/de not_active IP Right Cessation
- 2000-02-15 KR KR1020017010121A patent/KR20010102038A/ko active IP Right Grant
- 2000-02-15 NZ NZ513429A patent/NZ513429A/en not_active IP Right Cessation
- 2000-02-15 PT PT00903832T patent/PT1161235E/pt unknown
- 2000-02-15 CN CN008050961A patent/CN1344159B/zh not_active Expired - Fee Related
- 2000-02-15 DK DK00903832T patent/DK1161235T3/da active
- 2000-02-15 MX MXPA01008245A patent/MXPA01008245A/es active IP Right Grant
- 2000-02-15 BR BR0008254-6A patent/BR0008254A/pt not_active Application Discontinuation
- 2000-02-15 DE DE60017878T patent/DE60017878T2/de not_active Expired - Fee Related
- 2000-02-15 CA CA002362281A patent/CA2362281C/en not_active Expired - Fee Related
- 2000-02-15 JP JP2000599383A patent/JP4708569B2/ja not_active Expired - Fee Related
- 2000-02-15 KR KR1020077004923A patent/KR20070034642A/ko not_active Application Discontinuation
- 2000-02-15 AU AU25590/00A patent/AU775242B2/en not_active Ceased
- 2000-02-15 IL IL14484700A patent/IL144847A0/xx active IP Right Grant
- 2000-02-15 WO PCT/GB2000/000511 patent/WO2000048591A1/en not_active Application Discontinuation
- 2000-02-15 US US09/890,989 patent/US7087627B1/en not_active Expired - Fee Related
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2001
- 2001-08-09 IL IL144847A patent/IL144847A/en not_active IP Right Cessation
- 2001-08-14 ZA ZA200106688A patent/ZA200106688B/en unknown
- 2001-08-15 NO NO20013966A patent/NO20013966L/no unknown
-
2002
- 2002-04-08 HK HK02102577.5A patent/HK1040919B/zh not_active IP Right Cessation
-
2006
- 2006-05-01 US US11/416,283 patent/US20060198846A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000048591A1 (en) | 2000-08-24 |
| US20060198846A1 (en) | 2006-09-07 |
| ES2237407T3 (es) | 2005-08-01 |
| NO20013966L (no) | 2001-10-15 |
| IL144847A (en) | 2006-10-31 |
| MXPA01008245A (es) | 2002-10-23 |
| IL144847A0 (en) | 2002-06-30 |
| KR20070034642A (ko) | 2007-03-28 |
| PT1161235E (pt) | 2005-05-31 |
| AU775242B2 (en) | 2004-07-22 |
| HK1040919A1 (en) | 2002-06-28 |
| DE60017878T2 (de) | 2006-01-26 |
| DK1161235T3 (da) | 2005-05-09 |
| CA2362281C (en) | 2008-11-18 |
| CA2362281A1 (en) | 2000-08-24 |
| US7087627B1 (en) | 2006-08-08 |
| DE60017878D1 (de) | 2005-03-10 |
| EP1161235A1 (de) | 2001-12-12 |
| EP1161235B1 (de) | 2005-02-02 |
| NZ513429A (en) | 2003-10-31 |
| NO20013966D0 (no) | 2001-08-15 |
| CN1344159A (zh) | 2002-04-10 |
| GB9903404D0 (en) | 1999-04-07 |
| CN1344159B (zh) | 2011-09-28 |
| JP4708569B2 (ja) | 2011-06-22 |
| BR0008254A (pt) | 2001-11-06 |
| JP2002537251A (ja) | 2002-11-05 |
| KR20010102038A (ko) | 2001-11-15 |
| HK1040919B (zh) | 2005-05-13 |
| AU2559000A (en) | 2000-09-04 |
| ATE288264T1 (de) | 2005-02-15 |
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