ZA200105799B - Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders. - Google Patents
Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders. Download PDFInfo
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- ZA200105799B ZA200105799B ZA200105799A ZA200105799A ZA200105799B ZA 200105799 B ZA200105799 B ZA 200105799B ZA 200105799 A ZA200105799 A ZA 200105799A ZA 200105799 A ZA200105799 A ZA 200105799A ZA 200105799 B ZA200105799 B ZA 200105799B
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
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- 210000002826 placenta Anatomy 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
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- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001583 poly(oxyethylated polyols) Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
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- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
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- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
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- 238000011146 sterile filtration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
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- 210000003523 substantia nigra Anatomy 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
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- 239000002511 suppository base Substances 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
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- 108010064880 trkB Receptor Proteins 0.000 description 1
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- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/232,171 US6656474B1 (en) | 1999-01-15 | 1999-01-15 | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105799B true ZA200105799B (en) | 2002-01-24 |
Family
ID=22872143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105799A ZA200105799B (en) | 1999-01-15 | 2001-07-13 | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6656474B1 (https=) |
| EP (1) | EP1146899B1 (https=) |
| JP (1) | JP4489303B2 (https=) |
| AT (1) | ATE345811T1 (https=) |
| AU (1) | AU775860B2 (https=) |
| CA (1) | CA2360252C (https=) |
| DE (1) | DE60031951D1 (https=) |
| IL (2) | IL144315A0 (https=) |
| NO (1) | NO329488B1 (https=) |
| NZ (1) | NZ512968A (https=) |
| TR (2) | TR200102767T2 (https=) |
| WO (1) | WO2000041719A1 (https=) |
| ZA (1) | ZA200105799B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| ATE446366T1 (de) * | 2000-06-22 | 2009-11-15 | Genentech Inc | Agonistische monoklonale antikörper gegen trkc |
| US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
| EP1620127A4 (en) * | 2003-03-20 | 2007-04-04 | Rinat Neuroscience Corp | METHOD FOR TREATING TAXOL-INDUCED ANTI-FERROUS DISORDER |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US20100094560A1 (en) * | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| AU2010362444B2 (en) | 2010-10-14 | 2015-08-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| ES2870085T3 (es) | 2013-06-26 | 2021-10-26 | Xigen Inflammation Ltd | Inhibidores peptídicos permeables a células de la ruta de transducción de señales de JNK para el tratamiento de la cistitis |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987136A (en) * | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
| US5962404A (en) * | 1989-08-28 | 1999-10-05 | Yeda Research & Development Co., Ltd. | Enzymatically-produced oligodendrocyte cytotoxic dimeric IL-2 factor |
| US6174701B1 (en) * | 1989-12-12 | 2001-01-16 | Genentech, Inc. | Neuronal factor |
| DE69327113D1 (de) * | 1992-09-14 | 1999-12-30 | Regeneron Pharma | Methode zum erzeugen von analgie mittels neurotrophine |
| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| DK0755446T3 (da) * | 1994-04-25 | 2007-01-29 | Genentech Inc | Cardiotrophin og anvendelser deraf |
| US5759775A (en) * | 1994-10-27 | 1998-06-02 | Genetech, Inc. | Methods for detecting nucleic acids encoding AL--1 neurotrophic factor |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| US6211142B1 (en) | 1995-03-10 | 2001-04-03 | Genentech, Inc. | Compositions comprising gas6 polypeptides and articles of manufacture comprising the same |
| US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
| JP3540912B2 (ja) * | 1997-03-28 | 2004-07-07 | 京セラ株式会社 | 釣糸用ガイド部材 |
| JP2001527402A (ja) | 1997-04-25 | 2001-12-25 | ジェネンテック，インコーポレーテッド | Ｎｇｆ変異体 |
| US20020002269A1 (en) * | 1998-09-29 | 2002-01-03 | Jeffrey D. Milbrandt | Artemin, a neurotrophic factor |
-
1999
- 1999-01-15 US US09/232,171 patent/US6656474B1/en not_active Expired - Lifetime
-
2000
- 2000-01-11 CA CA2360252A patent/CA2360252C/en not_active Expired - Lifetime
- 2000-01-11 TR TR2001/02767T patent/TR200102767T2/xx unknown
- 2000-01-11 AU AU29636/00A patent/AU775860B2/en not_active Expired
- 2000-01-11 EP EP00908254A patent/EP1146899B1/en not_active Expired - Lifetime
- 2000-01-11 WO PCT/US2000/000682 patent/WO2000041719A1/en not_active Ceased
- 2000-01-11 JP JP2000593329A patent/JP4489303B2/ja not_active Expired - Lifetime
- 2000-01-11 NZ NZ512968A patent/NZ512968A/en not_active IP Right Cessation
- 2000-01-11 AT AT00908254T patent/ATE345811T1/de not_active IP Right Cessation
- 2000-01-11 TR TR2002/01875T patent/TR200201875T2/xx unknown
- 2000-01-11 IL IL14431500A patent/IL144315A0/xx active IP Right Grant
- 2000-01-11 DE DE60031951T patent/DE60031951D1/de not_active Expired - Lifetime
-
2001
- 2001-07-13 ZA ZA200105799A patent/ZA200105799B/en unknown
- 2001-07-13 NO NO20013493A patent/NO329488B1/no not_active IP Right Cessation
- 2001-07-13 IL IL144315A patent/IL144315A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200201875T2 (tr) | 2002-09-23 |
| EP1146899A1 (en) | 2001-10-24 |
| NO329488B1 (no) | 2010-10-25 |
| EP1146899A4 (en) | 2003-03-05 |
| IL144315A (en) | 2008-08-07 |
| JP2002534479A (ja) | 2002-10-15 |
| ATE345811T1 (de) | 2006-12-15 |
| WO2000041719A1 (en) | 2000-07-20 |
| NO20013493L (no) | 2001-09-17 |
| US6656474B1 (en) | 2003-12-02 |
| IL144315A0 (en) | 2002-05-23 |
| NZ512968A (en) | 2003-09-26 |
| CA2360252A1 (en) | 2000-07-20 |
| EP1146899B1 (en) | 2006-11-22 |
| AU2963600A (en) | 2000-08-01 |
| JP4489303B2 (ja) | 2010-06-23 |
| AU775860B2 (en) | 2004-08-19 |
| CA2360252C (en) | 2010-11-02 |
| TR200102767T2 (tr) | 2002-04-22 |
| DE60031951D1 (de) | 2007-01-04 |
| WO2000041719A9 (en) | 2001-08-30 |
| NO20013493D0 (no) | 2001-07-13 |
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