ZA200104490B - Aβ-peptide screening assay. - Google Patents
Aβ-peptide screening assay. Download PDFInfo
- Publication number
- ZA200104490B ZA200104490B ZA200104490A ZA200104490A ZA200104490B ZA 200104490 B ZA200104490 B ZA 200104490B ZA 200104490 A ZA200104490 A ZA 200104490A ZA 200104490 A ZA200104490 A ZA 200104490A ZA 200104490 B ZA200104490 B ZA 200104490B
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- South Africa
- Prior art keywords
- secretase
- seq
- nucleotide sequence
- protein
- app
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0335—Genetically modified worms
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/703—Worms, e.g. Caenorhabdities elegans
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
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- Neurosurgery (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19856261A DE19856261C1 (de) | 1998-12-07 | 1998-12-07 | Aß-Peptid Screening Assay |
Publications (1)
Publication Number | Publication Date |
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ZA200104490B true ZA200104490B (en) | 2002-06-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200104490A ZA200104490B (en) | 1998-12-07 | 2001-05-31 | Aβ-peptide screening assay. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7109027B2 (ja) |
EP (1) | EP1137810B1 (ja) |
JP (1) | JP4594529B2 (ja) |
KR (1) | KR100814265B1 (ja) |
CN (1) | CN1261589C (ja) |
AT (1) | ATE394505T1 (ja) |
AU (1) | AU766751B2 (ja) |
BR (1) | BR9915982A (ja) |
CA (1) | CA2354154C (ja) |
DE (2) | DE19856261C1 (ja) |
HK (1) | HK1041714A1 (ja) |
WO (1) | WO2000034511A2 (ja) |
ZA (1) | ZA200104490B (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19920514A1 (de) * | 1999-05-05 | 2000-11-16 | Boehringer Ingelheim Pharma | Methoden zur Auffindung von Proteasen, die spezifisch membrangebundene Substrate spalten |
AU2001237412A1 (en) * | 2000-02-25 | 2001-09-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines |
US6713248B2 (en) | 2000-04-03 | 2004-03-30 | Bristol-Myers Squibb Company | Methods for detection of gamma-secretase activity and identification of inhibitors thereof |
EP1268755A1 (en) * | 2000-04-05 | 2003-01-02 | Esbatech AG | Method to identify polypeptides with protease activity |
US7081337B2 (en) | 2001-03-30 | 2006-07-25 | Board Of Regents, The University Of Texas System | Methods for modulating transcriptional activation using mint proteins |
US6649346B2 (en) * | 2001-03-30 | 2003-11-18 | Board Of Regents, The University Of Texas | Methods of identifying agents that affect cleavage of amyloid-β precursor protein |
WO2003011036A1 (en) * | 2001-07-27 | 2003-02-13 | Internet Agencies Pty Ltd | An improved food product |
GB0202276D0 (en) * | 2002-01-31 | 2002-03-20 | Eisai London Res Lab Ltd | Assays |
EP1578356A4 (en) * | 2002-02-27 | 2007-08-15 | Merck & Co Inc | ASSAYS FOR CONTROLLING MOLECULAR MATURATION OF AN AMYLOID PRECURSOR PROTEIN |
US20060068388A1 (en) * | 2002-04-18 | 2006-03-30 | Esbatech Ag | Method for the identification of modulators of a secretase activity |
EP1481987A1 (en) | 2003-05-26 | 2004-12-01 | Aventis Pharma Deutschland GmbH | Method for screening inhibitors of the gamma-secretase |
EP1507147A1 (en) * | 2003-08-12 | 2005-02-16 | Erasmus University Medical Center Rotterdam | Method for detecting low levels of a fusion protein |
US20110104821A1 (en) * | 2008-05-08 | 2011-05-05 | Takahiko Tokuda | ABeta-OLIGOMER MEASUREMENT METHOD |
CN101392027B (zh) * | 2008-07-03 | 2012-04-25 | 浙江大学 | 一种治疗阿尔茨海默病的融合蛋白及其制备方法 |
CN101863962B (zh) * | 2010-05-07 | 2013-02-27 | 清华大学 | 抑制beta分泌酶酶切作用的多肽及其应用 |
CN103450347A (zh) * | 2012-05-29 | 2013-12-18 | 四川百利药业有限责任公司 | 一种用于治疗阿尔兹海默症的多肽及基因疫苗 |
JP6636614B2 (ja) | 2015-04-30 | 2020-01-29 | ジャンスー・ヌオ−ベータ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | アルツハイマー病の治療に用いられる薬物および治療標的のスクリーニング方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69333269T2 (de) * | 1992-01-31 | 2004-07-29 | Abbott Laboratories, Abbott Park | Expressionssystem in säugetieren für hcv-proteine |
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
WO1994028412A1 (en) * | 1993-05-28 | 1994-12-08 | The Miriam Hospital | Composition and method for in vivo imaging of amyloid deposits |
JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
WO1996040885A2 (en) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION |
US5744346A (en) * | 1995-06-07 | 1998-04-28 | Athena Neurosciences, Inc. | β-secretase |
US5866341A (en) * | 1996-04-03 | 1999-02-02 | Chugai Pharmaceutical Co., Ltd. | Compositions and methods for screening drug libraries |
CA2183901A1 (en) * | 1996-08-22 | 1998-02-23 | Johanna E. Bergmann | Targets for therapy and diagnosis of alzheimer's disease and down syndrome in humans |
WO1998015828A1 (en) * | 1996-10-07 | 1998-04-16 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
AU1684097A (en) * | 1996-12-11 | 1998-07-03 | Athena Neurosciences, Inc. | Beta-secretase isolated from human 293 cells |
DE19849073A1 (de) * | 1998-10-24 | 2000-04-27 | Aventis Pharma Gmbh | Transgener C. elegans als Modellorganismus für Untersuchungen zur Alzheimer'schen Krankheit |
-
1998
- 1998-12-07 DE DE19856261A patent/DE19856261C1/de not_active Expired - Fee Related
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1999
- 1999-11-27 JP JP2000586944A patent/JP4594529B2/ja not_active Expired - Fee Related
- 1999-11-27 KR KR1020017007026A patent/KR100814265B1/ko not_active IP Right Cessation
- 1999-11-27 BR BR9915982-1A patent/BR9915982A/pt not_active Application Discontinuation
- 1999-11-27 EP EP99963338A patent/EP1137810B1/de not_active Expired - Lifetime
- 1999-11-27 CN CNB998142042A patent/CN1261589C/zh not_active Expired - Fee Related
- 1999-11-27 AT AT99963338T patent/ATE394505T1/de not_active IP Right Cessation
- 1999-11-27 WO PCT/EP1999/009234 patent/WO2000034511A2/de active IP Right Grant
- 1999-11-27 AU AU19680/00A patent/AU766751B2/en not_active Ceased
- 1999-11-27 CA CA2354154A patent/CA2354154C/en not_active Expired - Fee Related
- 1999-11-27 DE DE59914752T patent/DE59914752D1/de not_active Expired - Lifetime
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2001
- 2001-02-27 US US09/794,975 patent/US7109027B2/en not_active Expired - Fee Related
- 2001-05-31 ZA ZA200104490A patent/ZA200104490B/en unknown
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2002
- 2002-05-07 HK HK02103437A patent/HK1041714A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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AU766751B2 (en) | 2003-10-23 |
HK1041714A1 (en) | 2002-07-19 |
AU1968000A (en) | 2000-06-26 |
CA2354154A1 (en) | 2000-06-15 |
CN1261589C (zh) | 2006-06-28 |
JP2002531141A (ja) | 2002-09-24 |
US20010034884A1 (en) | 2001-10-25 |
DE19856261C1 (de) | 2000-03-30 |
KR100814265B1 (ko) | 2008-03-18 |
EP1137810A2 (de) | 2001-10-04 |
WO2000034511A2 (de) | 2000-06-15 |
DE59914752D1 (de) | 2008-06-19 |
WO2000034511A3 (de) | 2000-11-16 |
CA2354154C (en) | 2011-01-04 |
JP4594529B2 (ja) | 2010-12-08 |
EP1137810B1 (de) | 2008-05-07 |
US7109027B2 (en) | 2006-09-19 |
KR20010080695A (ko) | 2001-08-22 |
ATE394505T1 (de) | 2008-05-15 |
BR9915982A (pt) | 2001-09-11 |
CN1329674A (zh) | 2002-01-02 |
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