AU2001237412A1 - Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines - Google Patents

Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines

Info

Publication number
AU2001237412A1
AU2001237412A1 AU2001237412A AU3741201A AU2001237412A1 AU 2001237412 A1 AU2001237412 A1 AU 2001237412A1 AU 2001237412 A AU2001237412 A AU 2001237412A AU 3741201 A AU3741201 A AU 3741201A AU 2001237412 A1 AU2001237412 A1 AU 2001237412A1
Authority
AU
Australia
Prior art keywords
lines
intramembrane
presenilin
deficient
screening methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237412A
Inventor
Wim Annaert
Bart De Strooper
An Herreman
Luc Schoonjans
Lutgarde Serneels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Publication of AU2001237412A1 publication Critical patent/AU2001237412A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001237412A 2000-02-25 2001-02-21 Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines Abandoned AU2001237412A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00200671 2000-02-25
EP00200671 2000-02-25
PCT/EP2001/002127 WO2001062897A1 (en) 2000-02-25 2001-02-21 Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines

Publications (1)

Publication Number Publication Date
AU2001237412A1 true AU2001237412A1 (en) 2001-09-03

Family

ID=8171102

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237412A Abandoned AU2001237412A1 (en) 2000-02-25 2001-02-21 Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines

Country Status (4)

Country Link
US (1) US20030059938A1 (en)
EP (1) EP1257633A1 (en)
AU (1) AU2001237412A1 (en)
WO (1) WO2001062897A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1495329B1 (en) * 2002-04-18 2006-03-29 Esbatech AG Method for the identification of modulators of a secretase activity
ES2293047T3 (en) * 2002-11-26 2008-03-16 PHARMACIA & UPJOHN COMPANY LLC SUBSTRATES BASED ON SOLVABLE NOTCHES FOR GAMMA SECRETASA AND PROCEDURES AND COMPOSITIONS FOR USE.
ATE371724T1 (en) * 2003-09-05 2007-09-15 Cellzome Ag TREATMENT OF NEURODEGENERATIVE DISEASES
WO2006015622A1 (en) * 2004-08-09 2006-02-16 Cellzome Ag Treatment of neurodegenerative diseases by the use of degs inhibitors
US20060266367A1 (en) * 2005-05-27 2006-11-30 Alisa Noce Nasal dilator
WO2007123680A2 (en) 2006-03-31 2007-11-01 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory
US8129334B2 (en) * 2006-03-31 2012-03-06 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103523A (en) * 1996-04-29 2000-08-15 Thromb-X N.V. Pluripotent rabbit cell lines and method of making
CA2290039A1 (en) * 1997-05-14 1998-11-19 Merck & Co., Inc. Transgenic animal expressing non-native wild-type and familial alzheimer's disease mutant presenilin 1 protein on native presenilin 1 null background
DE19856261C1 (en) * 1998-12-07 2000-03-30 Hoechst Marion Roussel De Gmbh Detection of gamma-secretase by detection of A-beta peptide useful for determining gamma-secretase activity and for identifying inhibitors
DE19920514A1 (en) * 1999-05-05 2000-11-16 Boehringer Ingelheim Pharma Methods for finding proteases that specifically cleave membrane-bound substrates

Also Published As

Publication number Publication date
EP1257633A1 (en) 2002-11-20
WO2001062897A1 (en) 2001-08-30
US20030059938A1 (en) 2003-03-27

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