ZA200102942B - Aryl-{4-fluoro-4-[(2-pyrid-2-ylethylamino)methyl]-1-peperidyl}-methanone derivatives as 5-HT1 receptor agonists. - Google Patents

Aryl-{4-fluoro-4-[(2-pyrid-2-ylethylamino)methyl]-1-peperidyl}-methanone derivatives as 5-HT1 receptor agonists. Download PDF

Info

Publication number
ZA200102942B
ZA200102942B ZA200102942A ZA200102942A ZA200102942B ZA 200102942 B ZA200102942 B ZA 200102942B ZA 200102942 A ZA200102942 A ZA 200102942A ZA 200102942 A ZA200102942 A ZA 200102942A ZA 200102942 B ZA200102942 B ZA 200102942B
Authority
ZA
South Africa
Prior art keywords
formula
compound
compounds
fluoro
pharmaceutically acceptable
Prior art date
Application number
ZA200102942A
Other languages
English (en)
Inventor
Bernard Vacher
Bernard Bonnaud
Wouter Koek
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of ZA200102942B publication Critical patent/ZA200102942B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200102942A 1998-10-09 2001-04-10 Aryl-{4-fluoro-4-[(2-pyrid-2-ylethylamino)methyl]-1-peperidyl}-methanone derivatives as 5-HT1 receptor agonists. ZA200102942B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9812660A FR2784378B1 (fr) 1998-10-09 1998-10-09 Nouveaux derives d'aryl-(4-fluoro-4-[(2-pyridin-2-yl- ethylamino)-methyl]-piperidin-1-yl)-methanone, leur procede de preparation et leur utilisation a titre de medicaments

Publications (1)

Publication Number Publication Date
ZA200102942B true ZA200102942B (en) 2002-05-02

Family

ID=9531367

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200102942A ZA200102942B (en) 1998-10-09 2001-04-10 Aryl-{4-fluoro-4-[(2-pyrid-2-ylethylamino)methyl]-1-peperidyl}-methanone derivatives as 5-HT1 receptor agonists.

Country Status (14)

Country Link
US (1) US6448268B1 (zh)
EP (1) EP1119564B1 (zh)
JP (1) JP2003514764A (zh)
CN (1) CN1160348C (zh)
AT (1) ATE229951T1 (zh)
AU (1) AU761122B2 (zh)
BR (1) BR9914331A (zh)
CA (1) CA2346506C (zh)
DE (1) DE69904626T2 (zh)
DK (1) DK1119564T3 (zh)
ES (1) ES2187215T3 (zh)
FR (1) FR2784378B1 (zh)
WO (1) WO2000021953A1 (zh)
ZA (1) ZA200102942B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2840900B1 (fr) * 2002-06-18 2005-02-25 Pf Medicament Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments
FR2852244B1 (fr) * 2003-03-13 2007-09-07 Pf Medicament Utilisation de derives de pyridin-2-yl-methylamine pour la preparation d'un medicament destine au traitement des symptomes de la douleur chronique d'origine neuropathique ou psychogene
EP3260452A1 (en) * 2016-06-24 2017-12-27 Neurolixis Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-ht1a receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
US6448268B1 (en) 2002-09-10
FR2784378A1 (fr) 2000-04-14
EP1119564B1 (fr) 2002-12-18
EP1119564A1 (fr) 2001-08-01
ES2187215T3 (es) 2003-05-16
FR2784378B1 (fr) 2000-12-29
BR9914331A (pt) 2001-06-26
AU5990599A (en) 2000-05-01
WO2000021953A1 (fr) 2000-04-20
DE69904626D1 (en) 2003-01-30
ATE229951T1 (de) 2003-01-15
AU761122B2 (en) 2003-05-29
DE69904626T2 (de) 2003-10-23
DK1119564T3 (da) 2003-04-07
CN1325396A (zh) 2001-12-05
CA2346506C (fr) 2009-01-13
JP2003514764A (ja) 2003-04-22
CN1160348C (zh) 2004-08-04
CA2346506A1 (fr) 2000-04-20

Similar Documents

Publication Publication Date Title
US5834493A (en) Indole derivatives as 5-HT1A and/or 5-HT2 ligands
CN1934091B (zh) 治疗神经变性障碍的咪唑化合物
US6498168B2 (en) Muscarinic antagonists
EP0906301B1 (en) Benzofuryl derivatives and their use
CN102241667B (zh) 1-[(4-羟基哌啶-4基)甲基]吡啶-2(1h)-酮衍生物及其制备方法和用途
EP1870405A1 (en) Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
HU228356B1 (en) Tropane-derivatives, inhibiting neurotransmitter re-uptake, their preparation, pharmaceutical compositions containing them and use of the compounds
JPH0819123B2 (ja) 1−インドリルアルキル−4−(アルコキシピリミジニル)ピペラジン
JPS6112685A (ja) クロマン類及びクロメン類,それらの製法及びそれらを含む医薬組成物
KR20110025226A (ko) 신규한 테트라메틸 치환된 피페리딘 유도체 및 모노아민 신경전달물질 재흡수 억제제로서의 이의 용도
CZ20022319A3 (cs) Substituovaná fenylpiperazinová sloučenina a farmaceutický prostředek, který ji obsahuje
ZA200500467B (en) Novel aryl-{4-halo-4-[(heteroarylmethylamino)methyl]-piperidin-1-yl}methanone derivatives methods for production and use thereof as medicaments
SK2992000A3 (en) Tetrahydro gamma-carbolines
JPH037257A (ja) ピリジン誘導体及びそれを有効成分とする向精神剤
US6242448B1 (en) Trisubstituted-oxazole derivatives as serotonin ligands
US6448268B1 (en) Aryl-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone derivatives as 5-ht1 receptor antagonists
JPH01135772A (ja) 1−置換イミダゾール−5−カルボン酸及びカルボン酸誘導体の製造方法
MXPA01003586A (en) Aryl-{4-fluoro-4- [(2-pyridin-2-yl- ethylamino)-methyl]- piperidin-1- yl}-methanone derivatives as 5-ht1 receptor antagonists
JPH0733744A (ja) インダゾール誘導体およびその塩
JPH02503007A (ja) 抗精神病性γ‐カルボリンN‐オキシド
JPH069622A (ja) 2−アルコキシキノキサリン誘導体、その製造法およびその用途
JPH05201978A (ja) N−(4,7−ジメトキシ−2−インダニル)−1−(フェニルカルボニル)−n−プロピル−4−ピペリジンメタンアミン誘導体、その製造法および医薬への応用
JPS60214784A (ja) 複素環式化合物
US5185338A (en) Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
JPH0641079A (ja) ピリジン誘導体