DE69904626T2 - Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten - Google Patents

Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten

Info

Publication number
DE69904626T2
DE69904626T2 DE69904626T DE69904626T DE69904626T2 DE 69904626 T2 DE69904626 T2 DE 69904626T2 DE 69904626 T DE69904626 T DE 69904626T DE 69904626 T DE69904626 T DE 69904626T DE 69904626 T2 DE69904626 T2 DE 69904626T2
Authority
DE
Germany
Prior art keywords
piperidin
ethylamino
pyridin
fluoro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69904626T
Other languages
English (en)
Other versions
DE69904626D1 (en
Inventor
Bernard Vacher
Bernard Bonnaud
Wouter Koek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of DE69904626D1 publication Critical patent/DE69904626D1/de
Application granted granted Critical
Publication of DE69904626T2 publication Critical patent/DE69904626T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69904626T 1998-10-09 1999-10-07 Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten Expired - Lifetime DE69904626T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9812660A FR2784378B1 (fr) 1998-10-09 1998-10-09 Nouveaux derives d'aryl-(4-fluoro-4-[(2-pyridin-2-yl- ethylamino)-methyl]-piperidin-1-yl)-methanone, leur procede de preparation et leur utilisation a titre de medicaments
PCT/FR1999/002401 WO2000021953A1 (fr) 1998-10-09 1999-10-07 Derives d'aryl-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone comme agonistes du recepteur 5-ht1

Publications (2)

Publication Number Publication Date
DE69904626D1 DE69904626D1 (en) 2003-01-30
DE69904626T2 true DE69904626T2 (de) 2003-10-23

Family

ID=9531367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69904626T Expired - Lifetime DE69904626T2 (de) 1998-10-09 1999-10-07 Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten

Country Status (14)

Country Link
US (1) US6448268B1 (de)
EP (1) EP1119564B1 (de)
JP (1) JP2003514764A (de)
CN (1) CN1160348C (de)
AT (1) ATE229951T1 (de)
AU (1) AU761122B2 (de)
BR (1) BR9914331A (de)
CA (1) CA2346506C (de)
DE (1) DE69904626T2 (de)
DK (1) DK1119564T3 (de)
ES (1) ES2187215T3 (de)
FR (1) FR2784378B1 (de)
WO (1) WO2000021953A1 (de)
ZA (1) ZA200102942B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2840900B1 (fr) * 2002-06-18 2005-02-25 Pf Medicament Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments
FR2852244B1 (fr) 2003-03-13 2007-09-07 Pf Medicament Utilisation de derives de pyridin-2-yl-methylamine pour la preparation d'un medicament destine au traitement des symptomes de la douleur chronique d'origine neuropathique ou psychogene
EP3260452A1 (de) * 2016-06-24 2017-12-27 Neurolixis Verbindungen zur behandlung von serotoninsensitiven erkrankungen gesteuert durch 5-ht1a rezeptoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661266A1 (de) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituierte cyclische Aminverbindungen als 5HT2 Antagonisten
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
EP1119564A1 (de) 2001-08-01
CN1160348C (zh) 2004-08-04
DE69904626D1 (en) 2003-01-30
AU5990599A (en) 2000-05-01
WO2000021953A1 (fr) 2000-04-20
ES2187215T3 (es) 2003-05-16
FR2784378A1 (fr) 2000-04-14
DK1119564T3 (da) 2003-04-07
CA2346506C (fr) 2009-01-13
AU761122B2 (en) 2003-05-29
JP2003514764A (ja) 2003-04-22
ATE229951T1 (de) 2003-01-15
BR9914331A (pt) 2001-06-26
US6448268B1 (en) 2002-09-10
FR2784378B1 (fr) 2000-12-29
CN1325396A (zh) 2001-12-05
EP1119564B1 (de) 2002-12-18
ZA200102942B (en) 2002-05-02
CA2346506A1 (fr) 2000-04-20

Similar Documents

Publication Publication Date Title
DE60139021D1 (de) Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
DE60134874D1 (de) Benzodiazepin-derivate als gamma-secretase inhibitoren
PT1204654E (pt) Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina
ATE368650T1 (de) Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel
ATE314383T1 (de) 2-amino-propanol derivate
DE69815161D1 (de) Azindolethylaminderivate als Nikotin-acetylcholin-Rezeptor Bindung Verbindungen
DE60032524D1 (de) EP4 Rezeptor Ligand und Verwendung gegen neuropatischen Schmerzen, Colon Krebs, HIV und Migräne
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
IT1312115B1 (it) Composti amorfi e relative composizioni farmaceutiche
ATE210649T1 (de) Arylacrylamidderivate als 5ht1 agoniste oder antagoniste
ATE498600T1 (de) Inden derivate als pharmazeutika
EP1189900A4 (de) Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe
BR0212353A (pt) Composto, composição farmacêutica, e, uso de um composto
PT952154E (pt) N-acil- e n-aroil-aralquilamidas
BG105710A (en) 5ht1 antagonists for antidepressant therapy
DE69904626T2 (de) Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten
DE69819266D1 (de) Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
ATE301463T1 (de) Pharmazeutische zusammensetzungen enthaltend 17alpha-furanylester von 17beta-carbothioat androstanderivaten und einen muskarinrezeptorantagonist
UY26329A1 (es) Antagonistas de los receptores de vitronectina
DE60319743D1 (de) Phthalazinderivate als phosphodiesterase-4-hemmer
MXPA03002532A (es) Nuevos compuestos de indolina, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
ECSP992845A (es) Compuestos quimicos
YU39603A (sh) Jedinjenja piperazinilpirazina kao antagonisti serotonin 5-ht2 receptora
YU28701A (sh) N-(2-(heteroaril)etil)-3-fenilpiperidini, n-(2-(heteroaril) etil)-4-fenilpiperidin i srodna jedinjenja sa supstituentom u položaju 4 piperidinskog prstena

Legal Events

Date Code Title Description
8364 No opposition during term of opposition