ZA200007454B - New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use. - Google Patents
New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use. Download PDFInfo
- Publication number
- ZA200007454B ZA200007454B ZA200007454A ZA200007454A ZA200007454B ZA 200007454 B ZA200007454 B ZA 200007454B ZA 200007454 A ZA200007454 A ZA 200007454A ZA 200007454 A ZA200007454 A ZA 200007454A ZA 200007454 B ZA200007454 B ZA 200007454B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid addition
- fused
- aminothiazol
- compound
- propyl
- Prior art date
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- 229940039412 ketalar Drugs 0.000 description 1
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- 230000003902 lesion Effects 0.000 description 1
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- 238000010630 lipid peroxidation (MDA) assay Methods 0.000 description 1
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- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 210000001853 liver microsome Anatomy 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 229940101972 mirapex Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- FAEPKWUOGBOKAO-UHFFFAOYSA-N n,n-dipropyl-6,7,8,9-tetrahydro-3h-benzo[e]indol-7-amine Chemical class C1C(N(CCC)CCC)CCC2=C1C=CC1=C2C=CN1 FAEPKWUOGBOKAO-UHFFFAOYSA-N 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 210000001009 nucleus accumben Anatomy 0.000 description 1
- WLGDAKIJYPIYLR-UHFFFAOYSA-N octane-1-sulfonic acid Chemical compound CCCCCCCCS(O)(=O)=O WLGDAKIJYPIYLR-UHFFFAOYSA-N 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 239000003368 psychostimulant agent Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
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- 238000011894 semi-preparative HPLC Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 238000002907 substructure search Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 230000000007 visual effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802360A SE9802360D0 (sv) | 1998-07-01 | 1998-07-01 | New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007454B true ZA200007454B (en) | 2001-06-14 |
Family
ID=20411925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007454A ZA200007454B (en) | 1998-07-01 | 2000-12-13 | New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6291494B1 (hu) |
| EP (1) | EP1091946B1 (hu) |
| JP (1) | JP4714341B2 (hu) |
| CN (1) | CN1126747C (hu) |
| AT (1) | ATE261948T1 (hu) |
| AU (1) | AU745550B2 (hu) |
| CA (1) | CA2335560C (hu) |
| CZ (1) | CZ298751B6 (hu) |
| DE (1) | DE69915623T2 (hu) |
| HU (1) | HUP0104723A3 (hu) |
| NZ (1) | NZ508852A (hu) |
| PL (1) | PL202397B1 (hu) |
| SE (1) | SE9802360D0 (hu) |
| WO (1) | WO2000001680A1 (hu) |
| ZA (1) | ZA200007454B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0110519A (pt) * | 2000-05-04 | 2003-04-08 | Warner Lambert Co | Método para inibir a agregação de proteìnas amilóides e formar imagens dos depósitos de amilóides usando derivados de aminoindano |
| US20050197365A1 (en) * | 2004-02-27 | 2005-09-08 | Jeffrey Sterling | Diamino thiazoloindan derivatives and their use |
| WO2005084205A2 (en) * | 2004-02-27 | 2005-09-15 | Teva Pharmaceutical Industries, Ltd. | Diamino thiazoloindan derivatives and their use |
| WO2006043532A1 (ja) * | 2004-10-19 | 2006-04-27 | Ono Pharmaceutical Co., Ltd. | パーキンソン病治療剤 |
| AR061478A1 (es) * | 2006-06-19 | 2008-08-27 | Takeda Pharmaceutical | Compuesto triciclico y composicion farmaceutica |
| SA109300120B1 (ar) * | 2008-02-21 | 2011-10-08 | استرازينيكا ايه بي | مركب (R)- N*6*- إيثيل- 6، 7- داي هيدرو- 5H- إندينو [5، 6- d] ثيازول- 2، 6- داي أمين وأستخدامة كمضاد لحالات الذهان |
| CA3164598A1 (en) * | 2019-12-17 | 2021-06-24 | Dentsply Detrey Gmbh | Dental root canal filling composition comprising primary monoamine |
| AU2021322291A1 (en) * | 2020-08-06 | 2023-04-06 | Tactogen Inc | 2-aminoindane compounds for mental disorders or enhancement |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2055609A (en) * | 1934-11-03 | 1936-09-29 | Du Pont | Ar-tetrahydro-naphthothiazoles |
| DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
| EP0186087B1 (de) * | 1984-12-22 | 1989-08-23 | Dr. Karl Thomae GmbH | Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel |
| US4826860A (en) * | 1987-03-16 | 1989-05-02 | Warner-Lambert Company | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents |
-
1998
- 1998-07-01 SE SE9802360A patent/SE9802360D0/xx unknown
-
1999
- 1999-07-01 AT AT99935232T patent/ATE261948T1/de not_active IP Right Cessation
- 1999-07-01 NZ NZ508852A patent/NZ508852A/xx not_active IP Right Cessation
- 1999-07-01 CN CN99808052A patent/CN1126747C/zh not_active Expired - Fee Related
- 1999-07-01 WO PCT/SE1999/001197 patent/WO2000001680A1/en active IP Right Grant
- 1999-07-01 PL PL345066A patent/PL202397B1/pl not_active IP Right Cessation
- 1999-07-01 HU HU0104723A patent/HUP0104723A3/hu unknown
- 1999-07-01 DE DE69915623T patent/DE69915623T2/de not_active Expired - Lifetime
- 1999-07-01 JP JP2000558085A patent/JP4714341B2/ja not_active Expired - Fee Related
- 1999-07-01 US US09/720,911 patent/US6291494B1/en not_active Expired - Fee Related
- 1999-07-01 AU AU50751/99A patent/AU745550B2/en not_active Ceased
- 1999-07-01 CA CA002335560A patent/CA2335560C/en not_active Expired - Fee Related
- 1999-07-01 CZ CZ20004807A patent/CZ298751B6/cs not_active IP Right Cessation
- 1999-07-01 EP EP99935232A patent/EP1091946B1/en not_active Expired - Lifetime
-
2000
- 2000-12-13 ZA ZA200007454A patent/ZA200007454B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4714341B2 (ja) | 2011-06-29 |
| EP1091946A1 (en) | 2001-04-18 |
| CN1126747C (zh) | 2003-11-05 |
| WO2000001680A1 (en) | 2000-01-13 |
| EP1091946B1 (en) | 2004-03-17 |
| CA2335560A1 (en) | 2000-01-13 |
| PL345066A1 (en) | 2001-12-03 |
| SE9802360D0 (sv) | 1998-07-01 |
| US6291494B1 (en) | 2001-09-18 |
| AU745550B2 (en) | 2002-03-21 |
| HUP0104723A3 (en) | 2004-10-28 |
| CA2335560C (en) | 2008-06-03 |
| HUP0104723A2 (hu) | 2002-04-29 |
| CZ20004807A3 (cs) | 2001-11-14 |
| PL202397B1 (pl) | 2009-06-30 |
| CN1307569A (zh) | 2001-08-08 |
| NZ508852A (en) | 2002-10-25 |
| JP2002519414A (ja) | 2002-07-02 |
| CZ298751B6 (cs) | 2008-01-16 |
| AU5075199A (en) | 2000-01-24 |
| DE69915623T2 (de) | 2005-02-03 |
| ATE261948T1 (de) | 2004-04-15 |
| DE69915623D1 (de) | 2004-04-22 |
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