ZA200007075B - Antithrombotic compounds. - Google Patents
Antithrombotic compounds. Download PDFInfo
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- ZA200007075B ZA200007075B ZA200007075A ZA200007075A ZA200007075B ZA 200007075 B ZA200007075 B ZA 200007075B ZA 200007075 A ZA200007075 A ZA 200007075A ZA 200007075 A ZA200007075 A ZA 200007075A ZA 200007075 B ZA200007075 B ZA 200007075B
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- 238000013270 controlled release Methods 0.000 description 1
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-O dicyclohexylazanium Chemical compound C1CCCCC1[NH2+]C1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-O 0.000 description 1
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- 210000002889 endothelial cell Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
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- 230000023597 hemostasis Effects 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
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- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
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- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 230000003331 prothrombotic effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical class [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012622 synthetic inhibitor Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202037 | 1998-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007075B true ZA200007075B (en) | 2002-02-28 |
Family
ID=8233825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007075A ZA200007075B (en) | 1998-06-17 | 2000-11-30 | Antithrombotic compounds. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6486129B1 (zh) |
| EP (1) | EP1087992B1 (zh) |
| JP (1) | JP4369052B2 (zh) |
| KR (1) | KR100790910B1 (zh) |
| CN (1) | CN1261450C (zh) |
| AR (1) | AR019674A1 (zh) |
| AT (1) | ATE405580T1 (zh) |
| AU (1) | AU756493B2 (zh) |
| BR (1) | BR9911300A (zh) |
| CA (1) | CA2334863C (zh) |
| CO (1) | CO5080750A1 (zh) |
| CY (1) | CY1108567T1 (zh) |
| CZ (1) | CZ299382B6 (zh) |
| DE (1) | DE69939378D1 (zh) |
| DK (1) | DK1087992T3 (zh) |
| ES (1) | ES2312210T3 (zh) |
| HK (1) | HK1034266A1 (zh) |
| HU (1) | HU229088B1 (zh) |
| ID (1) | ID26614A (zh) |
| IL (2) | IL139955A0 (zh) |
| NO (1) | NO326057B1 (zh) |
| NZ (1) | NZ508623A (zh) |
| PE (1) | PE20000700A1 (zh) |
| PL (1) | PL199433B1 (zh) |
| PT (1) | PT1087992E (zh) |
| RU (1) | RU2225869C2 (zh) |
| SK (1) | SK286755B6 (zh) |
| TR (1) | TR200003710T2 (zh) |
| TW (1) | TWI221156B (zh) |
| WO (1) | WO1999065934A1 (zh) |
| ZA (1) | ZA200007075B (zh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2312210T3 (es) * | 1998-06-17 | 2009-02-16 | N.V. Organon | Composiciones antitromboticas. |
| TWI289566B (en) * | 1999-12-07 | 2007-11-11 | N.V.Organon | Antithrombotic compound |
| DE10049937A1 (de) * | 2000-10-06 | 2002-04-11 | Knoll Ag | Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten |
| KR20040096541A (ko) * | 2002-01-31 | 2004-11-16 | 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 | 인자 Ｘａ 활성을 저해하는 화합물 |
| DE10300049A1 (de) * | 2003-01-03 | 2004-07-15 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Faktor VIIa inhibieren |
| DE10330900B4 (de) * | 2003-07-01 | 2006-09-14 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt |
| EP1574516A1 (en) * | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Antithrombotic compound |
| TW200621794A (en) * | 2004-10-06 | 2006-07-01 | Akzo Nobel Nv | Pulmonary administration of an antithrombotic compound |
| TWI403334B (zh) * | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
| TWI376234B (en) * | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| CN101312747B (zh) * | 2005-10-10 | 2013-03-20 | Msd欧斯股份有限公司 | 包括生物素标记的抗血栓形成双重抑制剂 |
| US20090111769A1 (en) * | 2005-10-10 | 2009-04-30 | De Kort Martin | Antithrombotic Compound |
| EP2421878B1 (en) * | 2008-10-03 | 2017-06-14 | Glycan Biosciences LLC | Anionic oligosaccharide conjugates |
| US20220380478A1 (en) | 2019-07-01 | 2022-12-01 | Tonix Pharma Holdings Limited | Anti-cd154 antibodies and uses thereof |
| MX2023008055A (es) | 2021-01-06 | 2023-08-22 | Tonix Pharma Ltd | Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT84170B (pt) | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
| DE4115468A1 (de) | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
| DE4206858A1 (de) | 1992-03-05 | 1993-09-09 | Behringwerke Ag | Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| ES2147216T3 (es) * | 1993-09-01 | 2000-09-01 | Akzo Nobel Nv | Bisconjugados que comprenden dos sacaridos y un grupo de union. |
| IL120722A (en) * | 1996-05-08 | 1999-07-14 | Akzo Nobel Nv | Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them |
| ES2312210T3 (es) * | 1998-06-17 | 2009-02-16 | N.V. Organon | Composiciones antitromboticas. |
-
1999
- 1999-06-11 ES ES99927976T patent/ES2312210T3/es not_active Expired - Lifetime
- 1999-06-11 CZ CZ20004735A patent/CZ299382B6/cs not_active IP Right Cessation
- 1999-06-11 CN CNB998073997A patent/CN1261450C/zh not_active Expired - Fee Related
- 1999-06-11 ID IDW20002653A patent/ID26614A/id unknown
- 1999-06-11 EP EP99927976A patent/EP1087992B1/en not_active Expired - Lifetime
- 1999-06-11 KR KR1020007014317A patent/KR100790910B1/ko not_active IP Right Cessation
- 1999-06-11 PL PL345238A patent/PL199433B1/pl unknown
- 1999-06-11 WO PCT/EP1999/004100 patent/WO1999065934A1/en active IP Right Grant
- 1999-06-11 IL IL13995599A patent/IL139955A0/xx active IP Right Grant
- 1999-06-11 CA CA2334863A patent/CA2334863C/en not_active Expired - Lifetime
- 1999-06-11 RU RU2001101556/04A patent/RU2225869C2/ru not_active IP Right Cessation
- 1999-06-11 BR BR9911300-7A patent/BR9911300A/pt active Search and Examination
- 1999-06-11 AT AT99927976T patent/ATE405580T1/de active
- 1999-06-11 DE DE69939378T patent/DE69939378D1/de not_active Expired - Lifetime
- 1999-06-11 AU AU45129/99A patent/AU756493B2/en not_active Expired
- 1999-06-11 TR TR2000/03710T patent/TR200003710T2/xx unknown
- 1999-06-11 DK DK99927976T patent/DK1087992T3/da active
- 1999-06-11 US US09/719,841 patent/US6486129B1/en not_active Expired - Lifetime
- 1999-06-11 NZ NZ508623A patent/NZ508623A/xx not_active IP Right Cessation
- 1999-06-11 PT PT99927976T patent/PT1087992E/pt unknown
- 1999-06-11 HU HU0102764A patent/HU229088B1/hu not_active IP Right Cessation
- 1999-06-11 JP JP2000554759A patent/JP4369052B2/ja not_active Expired - Lifetime
- 1999-06-11 SK SK1922-2000A patent/SK286755B6/sk not_active IP Right Cessation
- 1999-06-14 TW TW088109931A patent/TWI221156B/zh not_active IP Right Cessation
- 1999-06-16 AR ARP990102871A patent/AR019674A1/es active IP Right Grant
- 1999-06-16 PE PE1999000534A patent/PE20000700A1/es not_active Application Discontinuation
- 1999-06-17 CO CO99037966A patent/CO5080750A1/es unknown
-
2000
- 2000-11-27 IL IL139955A patent/IL139955A/en not_active IP Right Cessation
- 2000-11-30 ZA ZA200007075A patent/ZA200007075B/en unknown
- 2000-12-12 NO NO20006317A patent/NO326057B1/no not_active IP Right Cessation
-
2001
- 2001-07-10 HK HK01104760A patent/HK1034266A1/xx not_active IP Right Cessation
-
2008
- 2008-11-14 CY CY20081101313T patent/CY1108567T1/el unknown
Also Published As
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