YU77302A - 8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni - Google Patents

8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni

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Publication number
YU77302A
YU77302A YU77302A YUP77302A YU77302A YU 77302 A YU77302 A YU 77302A YU 77302 A YU77302 A YU 77302A YU P77302 A YUP77302 A YU P77302A YU 77302 A YU77302 A YU 77302A
Authority
YU
Yugoslavia
Prior art keywords
compounds
uterus
estrogen
estratrienes
effect
Prior art date
Application number
YU77302A
Other languages
English (en)
Inventor
Olaf Peters
Alexander Hillisch
Ina Thieme
Walter Elger
Christa Hegele-Hartung
Uwe Kollenkirchen
Karl-Heinrich Fritzemeier
Vladimir Patchev
Original Assignee
Schering Aktiengesellschaft
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Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of YU77302A publication Critical patent/YU77302A/sh

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    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Abstract

Predlozeni pronalazak opisuje nove 8ß-supstituisane Estratriene opste formule I u kojoj R2, R3, R6, R6', R7, R7', R9, R11, R11', R12, R14, R15, R15', R16, R16', R17 i R17' imaju u opisu navedeno znacenje a R8 znaci racvasti ili ravnoclanasti, u datom slucaju delimicno ili potpuno halogenovani alkil- ili alkenilostatak sa do 5 atoma ugljenika etinil- ili prop-1-inilostatak, kao farmaceutske aktivne supstance, koje in vitro pokazuju veci afinitet na estrogene receptorske preparacije prostate pacova nego na estrogenske receptorske preparacije uterusa pacova i in vivo narocito preferencijalno dejstvo na kosti u poredjenju sa uterusom i/ili izrazeno dejstvo sto se tice stimulisanja ekspresije 5HT2a-receptora i transportera, njihovo dobijanje, njihovu terapeutsku primenu i farmaceutske oblike davanja, koji sadrze nova jedinjenja. Pronalazak opisuje dalje primenu ovih jedinjenja za tretiranje deficitom hormona izazvanih oboljenja i stanja kao i primenu 8ß-supstituisanog estratrienskog dela strukture u ukupnim strukturama jedinjenja, koja pokazuju disocijaciju u korist njihovog estrogenog dejstva na kostima u poredjenju prema uterusu.
YU77302A 2000-04-12 2001-04-12 8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni YU77302A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019167A DE10019167A1 (de) 2000-04-12 2000-04-12 Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P 2000-05-26 2000-05-26

Publications (1)

Publication Number Publication Date
YU77302A true YU77302A (sh) 2005-11-28

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ID=7639163

Family Applications (1)

Application Number Title Priority Date Filing Date
YU77302A YU77302A (sh) 2000-04-12 2001-04-12 8beta-hidrokarbil-supstituisani estratrieni kao selektivno delotvorni estrogeni

Country Status (11)

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JP (1) JP4860880B2 (sh)
KR (1) KR100825534B1 (sh)
AR (1) AR028329A1 (sh)
DE (2) DE10019167A1 (sh)
PE (1) PE20011215A1 (sh)
SI (1) SI1272504T1 (sh)
TW (1) TWI288138B (sh)
UA (1) UA79073C2 (sh)
UY (1) UY26665A1 (sh)
YU (1) YU77302A (sh)
ZA (1) ZA200209149B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK14632002A3 (sk) * 2000-04-12 2003-03-04 Schering Aktiengesellschaft Substituované estratriény a ich použitie ako selektívne účinných estrogénov
DE10151114A1 (de) * 2001-10-15 2003-04-17 Schering Ag 8ß-Substituierte-11ß-aryl-estra-2,3,5(10)-trienderivate
DE602004014020D1 (de) * 2003-11-26 2008-07-03 Bayer Schering Pharma Ag Prävention und behandlung von hypertonen herzerkrankungen mit den selektiven östrogenen 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol und 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol
EP2094651A1 (en) * 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
EP2014672A1 (en) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft 8-beta-substituted estratrienes as selectively active estrogens
WO2010057594A1 (en) * 2008-11-21 2010-05-27 Bayer Schering Pharma Aktiengesellschaft Drug delivery system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3806546A (en) 1969-06-18 1974-04-23 American Cyanamid Co Steroid-like compounds and method of synthesis
US3681407A (en) 1969-06-18 1972-08-01 American Cyanamid Co 3-methoxy 8{62 -methylestra 1,3,5(10),9(11)-tetraene-17{62 -carboxylic acid lower alkyl ester and intermediates in the preparation thereof
US3736345A (en) 1971-05-18 1973-05-29 American Cyanamid Co Steroid-like compounds and method of synthesis

Also Published As

Publication number Publication date
TWI288138B (en) 2007-10-11
AR028329A1 (es) 2003-05-07
PE20011215A1 (es) 2001-11-29
JP4860880B2 (ja) 2012-01-25
UY26665A1 (es) 2001-11-30
JP2003534248A (ja) 2003-11-18
DE50107204D1 (de) 2005-09-29
DE10019167A1 (de) 2001-10-18
ZA200209149B (en) 2007-10-31
KR100825534B1 (ko) 2008-04-25
KR20030028734A (ko) 2003-04-10
UA79073C2 (en) 2007-05-25
SI1272504T1 (sl) 2007-10-31

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